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Volumn 108, Issue 6, 2001, Pages 929-937

The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia

Author keywords

[No Author keywords available]

Indexed keywords

5 NITRO 2 (3 PHENYLPROPYLAMINO)BENZOIC ACID; BACTERIAL TOXIN; GLYCEROL; MANNITOL; PERMEASE; PHLORETIN; THIOUREA; UREA; VIRULENCE FACTOR;

EID: 0034836586     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI13045     Document Type: Article
Times cited : (79)

References (38)
  • 5
    • 0031961778 scopus 로고    scopus 로고
    • The role of internal urease in acid resistance of Helicobacter pylori
    • (1998) Gastroentrology , vol.114 , pp. 58-67
    • Scott, D.R.1
  • 6
    • 0035142006 scopus 로고    scopus 로고
    • Prolonged survival and cytoplasmic pH homeostasis of Helicobacter pylori at pH 1
    • (2000) Infect. Immun. , vol.69 , pp. 1178-1181
    • Stingl, K.1
  • 9
    • 0034132067 scopus 로고    scopus 로고
    • A pH-sensitive channel regulates urea access to Helicobacter pylori
    • (2000) Gastroenterology , vol.118 , pp. 249-250
    • Gordon, D.1
  • 11
    • 0031707478 scopus 로고    scopus 로고
    • Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment
    • (1998) Infect. Immun. , vol.66 , pp. 4832-4837
    • Nakamura, H.1
  • 15
    • 0028818757 scopus 로고
    • Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant
    • (1995) Biol. Chem. , vol.270 , pp. 23937-23940
    • De Bernard, M.1
  • 17
    • 0032981962 scopus 로고    scopus 로고
    • Helicobacter pylori vacuolating toxin forms anionselective channels in planar lipid bilayers: Possible implications for the mechanism of cellular vacuolation
    • (1999) Biophys. J. , vol.76 , pp. 1401-1409
    • Tombola, F.1
  • 20
    • 13044317274 scopus 로고    scopus 로고
    • Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity
    • (1999) EMBO J , vol.18 , pp. 5517-5527
    • Szabo, J.1
  • 21
    • 0032528956 scopus 로고    scopus 로고
    • Selective increase of the permeability of polarized epithehaliel cell monolayers by Helicobacter pylori vacuolating toxin
    • (1998) J. Clin. Invest. , vol.102 , pp. 813-820
    • Papini, E.1
  • 22
    • 0032842774 scopus 로고    scopus 로고
    • Helicobacter pylori VacA cytotoxin associated with the bacteria increases epithelial permeability independently of its vacuolating activity
    • (1999) Microbiology , vol.145 , pp. 2043-2050
    • Pelicic, V.1
  • 23
    • 0028879245 scopus 로고
    • Helicobacter pylori cytotoxin: Importance of native conformation for induction of neutralizing antibodies
    • (1995) Infect. Immun. , vol.63 , pp. 4476-4480
    • Menetri, R.1
  • 25
    • 0027372483 scopus 로고
    • Cloning and characterisation of the vasopressin-regulated urea transporter
    • (1993) Nature , vol.365 , pp. 844-847
    • You, G.1
  • 26
    • 0029736799 scopus 로고    scopus 로고
    • Low permeabilities of apical membtanes of barrier epithelia: What makes watertight membranes watertight?
    • (1996) Am. J. Physiol. , vol.271
    • Zeidel, M.L.1
  • 28
    • 0034730730 scopus 로고    scopus 로고
    • Reconstituting the barrier properties of water-tight epithelial membrane by design of leaflet-specific liposomes
    • (2000) J. Biol. Chem. , vol.275 , pp. 30176-30188
    • Hill, W.G.1    Zeidel, M.L.2
  • 29
    • 0032749462 scopus 로고    scopus 로고
    • Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori
    • (1999) FEBS Lett. , vol.460 , pp. 221-225
    • Tombola, F.1
  • 33
  • 36
    • 0022748005 scopus 로고
    • The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral call surface domains of MDCK cells
    • (1986) EMBO J. , vol.8 , pp. 1455-1464
    • Van Meer, G.1    Simons, K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.