Inhibition of DNA adduct formation and mutagenic action of 3-amino-1-methyl-5H-pyrido[4,3-b]indole by chlorophyllin-chitosan in rpsL transgenic mice

Japanese Journal of Cancer Research

Volumn 92, Issue 8, 2001, Pages 848-853

  Anzai, Nobuhiro ^a   Taniyama, Takehiro ^a   Nakandakari, Namiko ^a   Sugiyama, Chitose ^a   Negishi, Tomoe ^a   Hayatsu, Hikoya ^a   Negishi, Kazuo ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Chemoprevention; Chitosan; Chlorophyllin; Somatic mutation; Trp P 2

Indexed keywords

3 AMINO 1 METHYL 5H PYRIDO[4,3 B]INDOLE; CARCINOGEN; CHITOSAN; CHLOROPHYLL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIETARY INTAKE; DNA ADDUCT; ESCHERICHIA COLI; FEMALE; GENOTOXICITY; INHIBITION KINETICS; LIVER; MOUSE; MUTAGENESIS; MUTAGENIC ACTIVITY; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SPLEEN; TRANSGENIC MOUSE;

ANIMALS; CARBOLINES; CARCINOMA, HEPATOCELLULAR; CHITIN; CHITOSAN; CHLOROPHYLLIDES; CHROMATOGRAPHY, THIN LAYER; DIET; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; GENE FREQUENCY; LIVER NEOPLASMS; MICE; MICE, TRANSGENIC; MUTAGENESIS; MUTAGENICITY TESTS; MUTAGENS; RIBOSOMAL PROTEINS;

EID: 0034826667     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2001.tb01171.x     Document Type: Article

References (26)

1. "Food Borne Carcinogens: Heterocyclic Amines"
2. Dietary inhibitors of mutagenesis and carcinogenesis
3. Dietary interventions of human carcinogenesis
4. Adsorption of mutagens to chlorophyllinchitosan, and insoluble form of chlorophyllin
5. Chemo-preventive properties of chlorophyllin: Inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay
6. Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding in rats given chlorophyllin: Dose-response and time-course studies in the liver and colon
7. Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat
8. Inhibition of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-mediated DNA-adduct formation by chlorophyllin in Drosophila
9. Inhibition of the mutagenicity of amino acid pyrolysis products by hemin and other biological pyrrole pigments
10. Inhibitory activity of chlorophyllin on the genotoxicity of carcinogens in Drosophila
11. Effects of tea and chlorophyllin on the mutagenicity of N-hydroxy-IQ: Studies of enzyme inhibition, molecular complex formation, and degradation/scavenging of the active metabolites
12. Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats
13. Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat
14. Complex formation of heterocyclic amines with porphyrins: Its use in detection and prevention
15. Carcinogenicity in mice of mutagenic compounds from a tryptophan pyrolyzate
16. A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice
17. Inhibition of benzo[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice
18. Different mutation frequencies and spectra among organs by N-methyl-N-nitrosourea in rpsL (strA) transgenic mice
19. Studies of somatic mutation frequencies and spectra with a sensitive and efficient detection method by using transgenic mice
20. 32P-postlabeling analysis of non-radioactive aromatic carcinogen-DNA adducts
21. 32P-postlabeling method
22. Structural identification of a modified base in DNA covalently bound with mutagenic 3-amino-1-methyl-5H-pyrido[4,3-b]indole
23. DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue™ mice does not correlate with mutagenicity
24. Chlorophyllin, an antimutagen, acts as a tumor promoter in the rat-dimethylhydrazine colon carcinogenesis model
25. Chlorophyllin is both a positive and negative modifier of mutagenicity
26. Chitosan-based dietary foods