메뉴 건너뛰기




Volumn 39, Issue 3, 2001, Pages 13-33

Phase I cancer trials: A crucible of competing priorities

(1)  Miller, M a  

a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CANCER RESEARCH; CLINICAL TRIAL; DOCTOR PATIENT RELATION; HUMAN; MEDICAL ETHICS; PATIENT CARE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; REVIEW;

EID: 0034821660     PISSN: 00205907     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004311-200107000-00004     Document Type: Review
Times cited : (12)

References (65)
  • 1
    • 0000222512 scopus 로고    scopus 로고
    • The ethical analysis of clinical trials: New lessons for and from cancer research
    • Vanderpool HY, ed. The ethics of research involving human subjects: facing the 21st century. Frederick, MD: University Publishing Group
    • (1996) , pp. 319-338
    • Freedman, B.1
  • 2
    • 0010030912 scopus 로고
    • Philosophical reflections on human experimentation
    • (1969) Daedalus , vol.98 , pp. 219-245
    • Jonas, H.1
  • 4
    • 0019066579 scopus 로고
    • Physician-investigator/patient-subject: Exploring the logic and the tension
    • (1980) J Med Philos , vol.5 , pp. 215-224
    • Churchill, L.R.1
  • 5
    • 0030921468 scopus 로고    scopus 로고
    • Clinical trials of antitumor agents: Experimental design and timeline considerations
    • (1997) Cancer J (from Sci Am) , vol.3 , pp. 127-136
    • Frei, E.1
  • 9
    • 0021687914 scopus 로고
    • Clinical trials for the evaluation of cancer therapy
    • (1984) Cancer , vol.54 , Issue.SUPPL. , pp. 2609-2617
    • Fisher, B.1
  • 11
    • 0003704271 scopus 로고
    • A response to a purported ethical difficulty with randomized clinical trials involving cancer patients
    • (1992) J Clin Ethics , pp. 171-175
    • Freedman, B.1
  • 16
    • 0024452804 scopus 로고
    • Design and analysis of phase I clinical trials
    • (1989) Biometrics , vol.45 , pp. 925-937
    • Storer, B.1
  • 17
    • 0002186972 scopus 로고
    • Design and conduct of phase I trials
    • Buyse M, Staquet M, Sylvester R, eds. Cancer clinical trials: methods and practice. Oxford: Oxford University Press
    • (1984) , pp. 200-220
    • Van Hoff, D.1    Kuh, J.2    Clark, G.3
  • 19
    • 0021703047 scopus 로고
    • Design of phase I and II clinical trials in cancer: A statistician's view
    • (1984) Cancer Invest , vol.2 , pp. 483-491
    • Geller, N.L.1
  • 24
  • 42
    • 0027654735 scopus 로고
    • Ethics and clinical research revisited. A tribute to Henry K. Beecher
    • (1993) Hastings Cent Rep , vol.23 , pp. 31-39
    • Katz, J.1
  • 46
    • 0025651570 scopus 로고
    • Sequential design and analysis of dose finding studies in patients with life threatening disease
    • (1990) Fundam Clin Pharmacol , vol.4 , Issue.SUPPL. , pp. 81-91
    • O'Quigley, J.1
  • 47
    • 0025986460 scopus 로고
    • Methods for dose finding studies in cancer clinical trials: A review and results of a Monte Carlo study
    • (1991) Stat Med , vol.10 , pp. 1647-1664
    • O'Quigley, J.1    Chevret, S.2
  • 48
    • 0026725698 scopus 로고
    • Estimating the probability of toxicity at the recommended dose following a phase I clinical trial in cancer
    • published erratum appears in Biometrics 1994;50:322
    • (1992) Biometrics , vol.48 , pp. 853-862
    • O'Quigley, J.1
  • 49
    • 0029780751 scopus 로고    scopus 로고
    • Improved designs for dose escalation studies using pharmacokinetic measurements
    • (1996) Stat Med , vol.15 , pp. 1605-1618
    • Piantadosi, S.1    Liu, G.2
  • 51
    • 0029001313 scopus 로고
    • An extension of the continual reassessment methods using a preliminary up-and-down design in a dose finding study in cancer patients, in order to investigate a greater range of doses
    • discussion 923
    • (1995) Stat Med , vol.14 , pp. 911-922
    • Moller, S.1
  • 54
    • 0028060511 scopus 로고
    • Practical modifications of the continual reassessment method for phase I cancer clinical trials
    • (1994) J Biopharm Stat , vol.4 , pp. 147-164
    • Faries, D.1
  • 60
    • 84955541967 scopus 로고
    • The meaning of professionalism: Doctors' ethics and biomedical science
    • Engelhardt HT Jr, Callahan D, eds. Knowledge, value and belief. Hastings-on-Hudson, NY: Institute of Society, Ethics and Life Sciences
    • (1977) , pp. 254-278
    • Toulmin, S.1
  • 61
    • 85037383516 scopus 로고    scopus 로고
  • 62
    • 85037400373 scopus 로고    scopus 로고
  • 65
    • 85037395195 scopus 로고    scopus 로고
    • Phase I oncology trials
    • Amdur RJ, Bankert EA, eds. Institutional Review Board: management and function. Sudbury, MA; in press
    • Miller, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.