Pharmacokinetics of midazolam given as an intranasal spray to adult surgical patients

British Journal of Anaesthesia

Volumn 79, Issue 5, 1997, Pages 575-580

  Bjorkman S ^a   Rigemar, G ^b   Idvall, J ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b Vastervik Hospital   (Sweden)

Author keywords

Hypnotics benzodiazepine, midazolam; Pharmacokinetics, midazolam

Indexed keywords

MIDAZOLAM;

ADULT; ANESTHESIA; ARTICLE; BIOAVAILABILITY; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BIOAVAILABILITY; FEMALE; HUMAN; INTESTINE ABSORPTION; INTRANASAL DRUG ADMINISTRATION; MALE; PHARMACOKINETICS; PRIORITY JOURNAL; SURGICAL PATIENT;

EID: 1842366766     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/79.5.575     Document Type: Article

References (34)

1. Wilton NCT, Leigh J, Rosen DR, Pandit UA. Preanesthetic sedation of preschool children using intranasal midazolam. Anesthesiology 1988; 69: 972-975.
2. Malinovsky J-M, Lejus C, Servin F, Lepage J-Y, Le Normand Y, Testa S, Cozian A, Pinaud M. Plasma concentrations of midazolam after i.v., nasal or rectal administration in children. British Journal of Anaesthesia 1993; 70: 617-620.
3. Malinovsky J-M, Populaire C, Cozian A, Lepage J-Y, Lejus C, Pinaud M. Premedication with midazolam in children. Effect of intranasal, rectal and oral routes on plasma midazolam concentrations. Anaesthesia 1995; 50: 351-354.
4. Walbergh EJ, Wills RJ, Eckhert J. Plasma concentrations of midazolam in children following intranasal administration. Anesthesiology 1991; 74: 233-235.
5. Rey E, Delaunay L, Pons G, Murat I, Richard MO, SaintMaurice C, Olive G. Pharmacokinetics of midazolam in children: comparative study of intranasal and intravenous administration. European Journal of Clinical Pharmacology 1991; 41: 355-357.
6. Fösel T, Hack C, Knoll R, Kraus GB, Larsen R. Nasal midazolam in children, plasma concentrations and the effect on respiration. Paediatric Anaesthesia 1995; 5: 347-353.
7. Rosario M, Alves I, Luis AS. Intranasal midazolam for sedation in upper gastrointestinal endoscopy. Gastroenterology 1990; 98: A10.
8. Theissen O, Boileau S, Wahl D, Manel J, Laxenaire MC. Sédation par midazolam intranasal lors des endoscopies digestives hautes. Annales Francaises d'Anesthesie et de Réanimation 1991; 10: 450-455.
9. Kaufman E, Davidson E, Sheinkman Z, Magora F. Comparison between intranasal and intravenous midazolam sedation (with or without patient control) in a dental phobia clinic. Journal of Oral and Maxillofacial Surgery 1994; 52: 840-843.
10. Cheng ACK. Intranasal midazolam for rapidly sedating an adult patient. Anesthesia and Analgesia 1993; 76: 904.
11. Payne K, Mattheyse FJ, Liebenberg D, Dawes T. The pharmacokinetics of midazolam in paediatric patients. European Journal of Clinical Pharmacology 1989; 37: 267-272.
12. Heizmann P, Eckert M, Ziegler WH. Pharmacokinetics and bioavailability of midazolam in man. British Journal of Clinical Pharmacology 1983; 16: 43S-49S.
13. Bornemann LD, Min BH, Crews T, Rees MMC, Blumenthal HP, Colburn WA, Patel IH. Dose dependent pharmacokinetics of midazolam. European Journal of Clinical Pharmacology 1985; 29: 91-95.
14. Mandema JW, Tuk B, van Steveninck AL, Breimer DD, Cohen AF, Danhof M. Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α-hydroxymidazolam in healthy volunteers. Clinical Pharmacology and Therapeutics 1992; 51: 715-728.
15. Ziegler WH, Schalch E, Leishman B, Eckert M. Comparison of the effects of intra-venously administered midazolam, triazolam and their hydroxy metabolites. British Journal of Clinical Pharmacology 1983; 16: 63-69S.
16. Howard PJ, McClean E, Dundee JW. The estimation of midazolam, a water-soluble benzodiazepine by gas liquid chromatography. Anaesthesia 1985; 40: 664-668.
17. Björkman S, Fyge Å, Qi Z. Determination of the steady state tissue distribution of midazolam in the rat. Journal of Pharmaceutical Sciences 1996; 85: 887-889.
18. Puglisi CV, Pao J, Ferrara FJ, de Silva JAF. Determination of midazolam (Versed®) and its metabolites in plasma by high-performance liquid chromatography. Journal of Chromatography 1985; 344: 199-209.
19. Mather LE, Björkman S. Pitfalls in pharmacokinetics. Anaesthetic Pharmacology Review 1994; 2: 260-270.
20. Gibaldi M, Perrier D. Pharmacokinetics, 2nd Edn. New York: Marcel Dekker, 1982; 445-449.
21. Verotta D. An inequality-constrained least-squares deconvolution method. Journal of Pharmacokinetics and Biopharmaceutics 1989; 17: 269-289.
22. Gibaldi M, Perrier D. Pharmacokinetics, 2nd Edn. New York: Marcel Dekker, 1982; 63-72.
23. Allonen H, Ziegler G, Klotz U. Midazolam kinetics. Clinical Pharmacology and Therapeutics 1981; 30: 653-661.
24. Greenblatt DJ, Abernethy DR, Locniskar A, Harmatz JS, Limjuco RA, Shader RI. Effect of age, gender, and obesity on midazolam kinetics. Anesthesiology 1984; 61: 27-35.
25. Koopmans R, Dingemanse J, Danhof M, Horsten GPM, van Boxtel CJ. The influence of dosage time of midazolam on its pharmacokinetics and effects in humans. Clinical Pharmacology and Therapeutics 1991; 50: 16-24.
26. Harper KW, Collier PS, Dundee JW, Elliott P, Halliday NJ, Lowry KG. Age and nature of operation influence the pharmacokinetics of midazolam. British Journal of Anaesthesia 1985; 57: 866-871.
27. Dundee JW, Collier PS, Carlisle RTJ, Harper KW. Prolonged midazolam elimination half-life. British Journal of Clinical Pharmacology 1986; 21: 425-429.
28. Hudson RJ. Midazolam pharmacokinetics in patients undergoing abdominal aortic surgery. Anesthesia and Analgesia 1994; 79: 219-225.
29. Maitre PO, Bührer M, Thomson D, Stanski DR. A three-step approach combining bayesian regression and NONMEM population analysis: application to midazolam. Journal of Pharmacokinetics and Biopharmaceutics 1991; 19: 377-384.
30. Persson MP, Nilsson A, Hartvig P. Relation of sedation and amnesia to plasma concentrations of midazolam in surgical patients. Clinical Pharmacology and Therapeutics 1988; 43: 324-331.
31. Clausen TG, Wolff J, Hansen PB, Larsen F, Rasmussen SN, Dixon JS, Crevoisier C. Pharmacokinetics of midazolam and α-hydroxy-midazolam following rectal and intravenous administration. British Journal of Clinical Pharmacology 1988; 25: 457-463.
32. Greenblatt DJ, Ehrenberg BL, Gunderman J, Locniskar A, Scavone JM, Harmatz JS, Shader RI. Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam and placebo. Clinical Pharmacology and Therapeutics 1989; 45: 356-365.
33. Wills RJ, Khoo KC, Soni PP, Patel IH. Increased volume of distribution prolongs midazolam half-life. British Journal of Clinical Pharmacology 1990; 29: 269-272.
34. Breimer LTM, Hennis PJ, Burm AGL, Danhof M, Bovill JG, Spierdijk J, Vletter AA. Quantification of the EEG effect of midazolam by aperiodic analysis in volunteers. Clinical Pharmacokinetics 1990; 18: 245-253.