Ferrochelatase is present in Brucella abortus and is critical for its intracellular survival and virulence

Infection and Immunity

Volumn 69, Issue 10, 2001, Pages 6225-6230

  Almiron M ^a   Martinez M ^a   Sanjuan, N ^a   Ugalde, R A ^a  

^a INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

FERROCHELATASE;

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL METABOLISM; BACTERIAL VIRULENCE; BRUCELLA ABORTUS; CELL SURVIVAL; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; KNOCKOUT GENE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHAGOCYTE; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY;

ANIMALS; BRUCELLA ABORTUS; FERROCHELATASE; HELA CELLS; HEMIN; HUMANS; INTRACELLULAR FLUID; MACROPHAGES; MICE; MICE, INBRED BALB C; MUTAGENESIS; VIRULENCE;

EID: 0034819639     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.10.6225-6230.2001     Document Type: Article

References (38)

1. Crystal structure of ferrochelatase: The terminal enzyme in heme biosynthesis
2. Basical local alignment search tool
3. Intracellular trafficking of Brucella abortus in J774 macrophages
4. Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuole
5. Quelling the red menace: Haem capture by bacteria
6. Deletion of purE attenuates Brucella melitensis infection in mice
7. Immune response to the iron-deprivation-induced proteins of Salmonella typhi in typhoid fever
8. Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models
9. Characterization of a Bradyrhizobium japonicum ferrochelatase mutant and isolation of the hemH gene
10. Microbial iron transport
11. Structure prediction and fold recognition for the ferrochelatase family of proteins
12. Purification and characterisation of a water-soluble ferrochelatase from Bacillus subtilis
13. Nucleotide sequence of the Rhodobacter capsulatus hemH gene
14. Residual virulence of brucella abortus in the absence of the cytochrome bc (1) complex in a murine model in vitro and in vivo
15. Four new derivatives of the broad-host-range cloning vector pBBR1MCS, carrying different antibiotic-resistance cassettes
16. Dissociation and recombination between ligands and heme in a CO-sensing transcriptional activator CooA
17. Cloning and characterization of an outer membrane protein of Vibrio vulnificus required for heme utilization: Regulation of expression and determination of the gene sequence
18. Accumulation of protoporphyrin IX in light-sensitive mutants of Escherichia coli
19. Roles of Ile209 and Ile210 on the heme pocket structure and regulation of histidine kinase activity of oxygen sensor FixL from Rhizobium meliloti
20. Isolation and characterization of a light-sensitive mutant of Escherichia coli K-12 with a mutation in a gene that is required for the biosynthesis of ubiquinone
21. Effects of starvation for heme on the synthesis of porphyrins in Escherichia coli
22. Nucleotide sequence of the kanamycin resistance transposon Tn903
23. Brucella abortus transits through the autophagic pathway and replicates in the endoplasmic reticulum of nonprofessional phagocytes
24. Brucella abortus invasion and survival within professional and nonprofessional phagocytes
25. Iron metabolism in pathogenic bacteria
26. Gene discovery through genomic sequencing of Brucella abortus
27. Molecular basis of Brucella pathogenicity: An update
28. Characterization of ferrochelatase (hemH) mutations in Haemophilus influenzae
29. A homologue of an operon required for DNA transfer in Agrobacterium is required in Brucella abortus for virulence and intracellular multiplication
30. A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence
31. Molecular characterization, occurrence, and immunogenicity in infected sheep and cattle of two minor outer membrane proteins of Brucella abortus
32. Haem iron-transport system in enterohaemorrhagic Escherichia coli O157:H7
33. Neisseria gonorrhoeae heme biosynthetic mutants utilize heine and hemoglobin as a heme source but fail to grow within epithelial cells
34. Intracellular lifestyle of Brucella spp. Common genes with other animal pathogens, plant pathogens, and endosymbionts
35. Brucella, a monoespecific genus, as shown by deoxyribonucleic acid hybridization
36. Quantitative evaluation of Escherichia coli host strains for tolerance to cytosine methylation in plasmid and phage recombinants