Sensitivity of metallothionein-null mice to LPS/D-galactosamine-induced lethality

Biochemical and Biophysical Research Communications

Volumn 280, Issue 1, 2001, Pages 358-362

  Kimura, T ^a   Itoh, N ^a   Takehara, M ^a   Oguro, I ^a   Ishizaki, J I ^a   Nakanishi, T ^a   Tanaka, K ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

D galactosamine; Lipopolysaccharide; Metallothionein; 1 acid glycoprotein

Indexed keywords

ACUTE PHASE PROTEIN; BACTERIUM LIPOPOLYSACCHARIDE; CYSTEINE; ENDOTOXIN; GALACTOSAMINE; GENE PRODUCT; METALLOTHIONEIN; NITRIC OXIDE; OROSOMUCOID; THROMBOCYTE ACTIVATING FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENDOTOXEMIA; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; INFECTION SENSITIVITY; LETHALITY; MALE; METAL BINDING; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; SIGNAL TRANSDUCTION;

EID: 0034816365     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.4085     Document Type: Article

References (36)

1. The phenomenon of the acute phase response
2. 2 in mice
3. Inhibition of neutrophil superoxide production by human plasma alpha 1-antitrypsin
4. Rabbits with elevated serum C-reactive protein exhibit diminished neutrophil infiltration and vascular permeability in C5a-induced alveolitis
5. Protection by alpha 1-acid glycoprotein against tumor necrosis factor-induced lethality
6. Alpha1-Antitrypsin inhibits the lethal response to TNF in mice
7. Transgenic mice expressing rabbit C-reactive protein are resistant to endotoxemia
8. Blocking effect of anti-mouse interleukin-6 monoclonal antibody and glucocorticoid receptor antagonist, RU38486, on metallothionein-inducing activity of serum from lipopolysaccharide-treated mice
9. Targeting and germline transmission of a null mutation at the metallothionein I and II loci in mouse
10. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium
11. Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency
12. Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice
13. Enhanced renal toxicity by inorganic mercury in metallothionein-null mice
14. Protective role of metallothionein in renal toxicity of cisplatinum
15. Paracetamol hepatotoxicity in metallothionein-null mice
16. Metallothionein-null mice express altered genes during development
17. Molecular cloning of the complementary DNA for human tumor necrosis factor
18. Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line
19. Quantitative analysis of platelet-activating factor in human plasma. Application to patients with liver cirrhosis and disseminated intravascular coagulation
20. Physicochemical and functional identity of rabbit platelet-activating factor (PAF) released in vivo during IgE anaphylaxis with PAF released in vitro from IgE sensitized basophils
21. Molecular cloning of cDNAs corresponding to two genes of alpha 1-acid glycoprotein and characterization of two alleles of AGP-1 in the mouse
22. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models
23. Role of nitric oxide in lipopolysaccharide-induced hepatic injury in D-galactosamine-sensitized mice as an experimental endotoxic shock model
24. Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality
25. Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins
26. Inhibition of platelet aggregation by native and desialised alpha-1 acid glycoprotein
27. An effector role for platelets in systemic and local lipopolysaccharide-induced toxicity in mice, mediated by a CD11a- and CD54-dependent interaction with endothelium
28. Modulation of lipopolysaccharide-mediated activation in rat Kupffer cells by antioxidants
29. Nitric oxide: Cytotoxicity versus cytoprotection - How, why, when, and where?
30. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
31. Activation of nuclear factor kappaB: Potential role in metallothionein-mediated mitogenic response
32. Regulatory role of metallothionein in NF-kappaB activation
33. Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism
34. Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals
35. 2 with sulfhydryl groups in HL-60 cells: zinc-metallothionein and other sites
36. Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: Importance of an intracellular oxidant stress