KMD-3213. Treatment of BPH, α1-adrenoceptor antagonist

Drugs of the Future

Volumn 26, Issue 6, 2001, Pages 553-560

  Sorbera, L A ^a   Silvestre, J ^a   Castaner J ^a  

^a PROUS SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3 (1,4 BENZODIOXAN 2 YLMETHYLAMINO)PROPYL] 3(2H) PYRIDAZINONE; 4 (3,4 DIFLUOROPHENYL) 3,4 DIHYDRO 6 METHOXYMETHYL 2(1H) OXO 3,5 PYRIMIDINEDICARBOXYLIC ACID 5 METHYL ESTER 3 [3 [4 (2 PYRIDYL) 1 PIPERIDINYL]PROPYL]AMIDE; 5 METHYL 3 [3 [4 [2 (2,2,2 TRIFLUOROETHOXY)PHENYL] 1 PIPERAZINYL]PROPYL] 1H PYRIMIDINE 2,4 DIONE; AIO 8507; ALPHA 2 ADRENERGIC RECEPTOR; L 771688; L 780945; PRAZOSIN; RBX 2258; RO 70004; RWJ 38063; RWJ 69736; SILODOSIN; SNP 7915; TAMSULOSIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BROMINATION; DRUG STRUCTURE; PROSTATE HYPERTROPHY; RECEPTOR BINDING; RECEPTOR OCCUPANCY;

EID: 0034815381     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2001.026.06.626807     Document Type: Article

References (22)

1. 1-adrenoceptor antagonist, KMD-3213, and its suitability as a tritiated radioligand
2. 1a-adrenoceptor-selective antagonist: Characterization using recombinant human alpha 1-adrenoceptors and native tissues
3. 1-adrenoceptor antagonist, in human prostate and vasculature
4. 1-adrenoceptor antagonists for the treatment of benign prostatic hyperplasia
5. 1A-adrenoceptor subtype selectivity of KMD-3213 in rat tissues
6. 1-adrenoceptors in the rabbit iris: Pharmacological characterization and expression of mRNA
7. 1a-adrenoceptor
8. 1-adrenoceptor subtypes in rat tissues
9. 1-adrenoceptor-selective antagonist, on the contractions of rabbit prostate and rabbit and rat aorta
10. 1-adrenoceptor in human prostate
11. 1-adrenoceptor (AR) antagonist, on the blood pressure response to tilting in rats
12. 1a-adrenoceptor antagonist, tested in a novel rat model
13. 1A-adrenoceptor antagonist, on the prostatic urethral pressure and blood pressure in male decerebrate dogs
14. 1-antagonists for the treatment of urinary obstruction in benign prostatic hypertrophy (BPH)
15. Kissei and Daiichi will codevelop and comarket BPH Rx in Japan
16. 1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha 1-adrenoceptors
17. α-Adrenergic activity and cardiovascular effects of besipirdine HCI (HP 749) and metabolite P7480 in vitro and in the conscious rat and dog
18. 1A-adrenoceptor selective antagonists
19. 1D-adrenoceptor antagonist