Phosphoinositide 3-kinase inhibits megalin-mediated transcytosis of thyroglobulin across thyroid epithelial cells at a post-sorting level

European Journal of Endocrinology

Volumn 145, Issue 4, 2001, Pages 477-483

  Marino M ^a   Chiovato, L ^a   Lisi, S ^a   Pinchera, A ^a   McCluskey, R T ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LIOTHYRONINE; LOW DENSITY LIPOPROTEIN RECEPTOR; MEGALIN; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; THYROGLOBULIN; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL SELECTION; CELL SURFACE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEVICE; EXPERIMENT; HORMONE RELEASE; INCUBATION TIME; INTRACELLULAR TRANSPORT; KIDNEY CELL; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN TRANSPORT; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; TEMPERATURE; THYROID CELL; TRANSCYTOSIS;

EID: 0034814749     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1450477     Document Type: Article

References (38)

1. Folding and assembly of newly synthesized thyroglobulin occurs in a pre-Golgi compartment
2. Transient aggregation of nascent thyroglobulin in the endoplasmic reticulum: Relationship to the molecular chaperone, BiP
3. Hormonal regulation of thyroglobulin export from the endoplasmic reticulum of cultured thyrocytes
4. Role of thyroglobulin endocytic pathways in the control of thyroid hormone release
5. Megalin in thyroid physiology and pathology
6. Release and secretion of thyroid hormone
7. The thyroid hormone secretory pathway - Current dogmas and alternative hypotheses
8. Transcytosis in thyroid cells
9. Transcytosis in thyroid follicle cells: Regulation and implications for thyroglobulin transport
10. Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells: A novel function in the control of thyroid hormone release
11. Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor
12. Complete cloning and sequencing of rat gp330/megalin, a distinctive member of the low density lipoprotein receptor gene family
13. Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/a2MR, and the receptor-associated protein (RAP)
14. 2+-sensing protein
15. Megalin (gp330) is an endocytic receptor for thyroglobulin on cultured thyroid cells (FRTL-5 cells)
16. Circulating thyroglobulin derived from transcytosis is combined with a secretory component of its endocytic receptor megalin
17. Culture of hormone-dependent functional epithelial cells from rat thyroids
18. Evaluation of the rat thyroid cell strain FRTL-5 as an in vitro bioassay system for thyrotropin
19. Wortmannin, an inhibitor of phosphoinositide 3-kinase, inhibits transcytosis in polarized epithelial cells
20. Phospholipid signaling
21. Phosphatidylinositol 3-kinase
22. The assembly of signaling complexes by receptor tyrosine kinases
23. PI-3 kinase in signal transduction, cell transformation, and as a target for chemoprevention of cancer
24. Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways
25. The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin
26. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase
27. Identification of a heparin-binding region of rat thyroglobulin involved in megalin binding
28. Megalin (gp330): A putative endocytic receptor for thyroglobulin (Tg)
29. Analyses of the molecular forms of serum thyroglobulin from patients with Graves' disease, subacute thyroiditis or differentiated thyroid cancer by velocity sedimentation on sucrose gradient and western blot
30. The origin of the electrophoretic doublet of thyroglobulin
31. Induction of Heymann nephritis with a gp330/megalin fusion protein
32. The Fischer rat thyroid cell line FRTL-5 exhibits a nondiploid karyotype
33. Lack of thyroglobulin production supports the finding of the FRTL-5 cells with a nondiploid karyotype
34. Megalin-mediated transcytosis of thyroglobulin by thyroid cells is a calmodulin-dependent process
35. Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells
36. 2+-binding receptor with potential intracellular signalling properties
37. Phosphoinositides in membrane traffic
38. Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells