Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development

Biochemical and Biophysical Research Communications

Volumn 286, Issue 3, 2001, Pages 580-586

  Melis, Els ^a   Moons, Lieve ^a   De Mol, Maria ^a   Herbert, Jean Marc ^b   Mackman, Nigel ^c   Collen, Désiré ^a   Carmeliet, Peter ^a   Dewerchin, Mieke ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b SANOFI   (France)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Blood coagulation; Cytosolic deletion; Embryogenesis; Gene targeting; Signal transduction; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P42; PROTEIN P44; THROMBOPLASTIN;

ANIMAL CELL; ARTICLE; BLOOD CLOTTING; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOSOL; EMBRYO; EMBRYO DEVELOPMENT; EXON; FERTILITY; GENE CASSETTE; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE LOCUS; GENE TARGETING; GENETIC RECOMBINATION; INTRON; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; STEM CELL; SURVIVAL;

EID: 0034812792     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5425     Document Type: Article

References (43)

1. Cell biology of tissue factor, the principal initiator of blood coagulation
2. Blood-borne tissue factor: Another view of thrombosis
3. Platelet-associated tissue factor contributes to the collagen-triggered activation of blood coagulation
4. Activated human platelets express and release tissue factor in vitro
5. Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis
6. In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease
7. Role of tissue factor in embryonic blood vessel development
8. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation
9. Targeted disruption of the murine tissue factor gene results in embryonic lethality
10. Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumor cells in mice
11. Tissue factor is rapidly induced in arterial smooth muscle after balloon injury
12. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis
13. Role of tissue factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in vitro
14. Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque
15. Coagulation factors in nephrotic syndrome
16. Structural design and molecular evolution of a cytokine receptor superfamily
17. The structural biology of expression and function of tissue factor
18. The cytoplasmic domain of tissue factor is phosphorylated by a protein kinase C-dependent mechanism
19. Binding of human factor VIIa to tissue factor induces cytosolic Ca2+ signals in J82 cells, transfected COS-1 cells, Madin-Darby canine kidney cells and in human endothelial cells induced to synthesize tissue factor
20. Signal transduction via the mitogen-activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor
21. Binding of factor VIIa to tissue factor on keratinocytes induces gene expression
22. A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280
23. 2+ oscillations in Madin-Darby canine kidney cells only when proteolytically active
24. Coagulation factors VIIa and Xa induce cell signaling leading to up-regulation of the egr-1 gene
25. Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa
26. Specific activation of protease activated receptor 2 by the coagulation factor VIIa-tissue factor complex
27. Factor VIIa-induced p44/42 mitogen-activated protein kinase activation requires the proteolytic activity of factor VIIa and is independent of the tissue factor cytoplasmic domain
28. Exclusion of known protease-activated receptors in factor VIIa-induced signal transduction
29. Mouse embryogenesis requires the tissue factor extracellular domain but not the cytoplasmic domain
30. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
31. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
32. Maternally expressed PGK-Cre transgene as a tool for early and uniform activation of the Cre site-specific recombinase
33. Production of targeted embryonic stem cell clones
34. Bleeding time in laboratory animals. II. A comparison of different assay conditions in rats
35. Comparison of two experimental thrombosis models in rats effects of four glycosaminoglycans
36. Mouse antithrombotic assay: A simple method for the evaluation of antithrombotic agents in vivo. Potentiation of antithrombotic activity by ethyl alcohol
37. Tissue factor and factor VIIa receptor/ligand interactions induce proinflammatory effects in macrophages
38. Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis
39. Role of tissue factor in metastasis: Functions of the cytoplasmic and extracellular domains of the molecule
40. Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor
41. Lipid association, but not the transmembrane domain, is required for tissue factor activity. Substitution of the transmembrane domain with a phosphatidylinositol anchor
42. Tissue factor signaling