The Jackson toxic milk mouse as a model for copper loading

Mammalian Genome

Volumn 12, Issue 10, 2001, Pages 793-795

  Coronado, Veronica ^a   Nanji, Manoj ^a   Cox, Diane W ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DNA SEQUENCE; GENE MUTATION; MOLECULAR CLONING; MOUSE; MOUSE STRAIN; NONHUMAN; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILSON DISEASE;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; ANIMALS; CATION TRANSPORT PROTEINS; CLONING, MOLECULAR; CONSERVED SEQUENCE; COPPER; DISEASE MODELS, ANIMAL; DNA MUTATIONAL ANALYSIS; HEPATOLENTICULAR DEGENERATION; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MICE; MICE, INBRED STRAINS; MICE, MUTANT STRAINS; MILK; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PHENOTYPE; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA;

EID: 0034811959     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00335-001-3021-y     Document Type: Article

References (21)

1. Characterization of copper interactions with Alzheimer amyloid beta peptides: Identification of an attomolar-affinity copper binding site on amyloid beta 1-42
2. Morphological and chemical studies on a murine mutation (toxic milk) resulting in hepatic copper toxicosis
3. Acute cerebral neuronal necrosis in copper deficient offspring of female mice with the toxic milk mutation
4. Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation
5. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene
6. Oxidative stress and motor neurone disease
7. Wilson disease
8. Evidence of neuronal oxidative damage in Alzheimer's disease
9. His 1069Gln and six novel Wilson disease mutations: Analysis of relevance for early diagnosis and phenotype
10. Oxygen toxicity, oxygen radicals, transition metals and disease
11. The pathology and trace element status of the toxic milk mutant mouse
12. Oxidative stress and the pathogenesis of Parkinson's disease
13. Wilson disease mutations associated with uncommon haplotypes in Mediterranean patients
14. Copper, iron and zinc in Alzheimer's disease senile plaques
15. Defective localization of the Wilson disease protein (ATP7B) in the mammary gland of the toxic milk mouse and the effects of copper supplementation
16. Toxic milk, a new mutation affecting copper metabolism in the mouse
17. Research news
18. The toxic milk mouse is a murine model of Wilson disease
19. The Wilson disease gene: Spectrum of mutations and their consequences
20. Efficient detection of mutations in Wilson disease by manifold sequencing
21. The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene