Evidence that the intracellular domain of FGF receptor 2IIIb affects contact of the ectodomain with two FGF7 ligands

Biochemical and Biophysical Research Communications

Volumn 283, Issue 4, 2001, Pages 791-797

  Uematsu, Fumiyuki ^b   Jang, Jun Hyeog ^a   Kan, Mikio ^b   Wang, Fen ^b   Luo, Yongde ^b   McKeehan, Wallace L ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Heparan sulfate; Oligomeric complexes; Transmembrane signaling; Tyrosine kinases

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIMER; FIBROBLAST GROWTH FACTOR RECEPTOR; HEPARAN SULFATE; HEPARIN; LIGAND; OLIGOMER; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; COVALENT BOND; CROSS LINKING; CRYSTAL STRUCTURE; HUMAN; ISOTOPE LABELING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; RAT; SIGNAL TRANSDUCTION; STOICHIOMETRY;

EID: 0034811072     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4850     Document Type: Article

References (23)

1. The heparan sulfate-fibroblast growth factor family: Diversity of structure and function
2. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
3. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin
4. The glycine box: A determinant of specificity for fibroblast growth factor
5. Expression and transforming activity of a variant of the heparin-binding fibroblast growth factor receptor (flg) gene resulting from splicing of the alpha exon at an alternate 3′-acceptor site
6. Ligand-specific structural domains in the fibroblast growth factor receptor
7. Ligand binding properties of binary complexes of heparin and immunoglobulin-like modules of FGF receptor 2
8. Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase
9. Divalent cations and heparin/heparan sulfate cooperate to control assembly and activity of the fibroblast growth factor receptor complex
10. Structural interactions of fibroblast growth factor receptor with its ligands
11. Structural basis for FGF receptor dimerization and activation
12. Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition
13. Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces
14. Inactivation of human fibroblast growth factor-1 (FGF-1) activity by interaction with copper ions involves FGF-1 dimer formation induced by copper-catalyzed oxidation
15. A homeo-interaction sequence in the ectodomain of the fibroblast growth factor receptor
16. Heparan sulfate is required for interaction and activation of the epithelial cell fibroblast growth factor receptor-2IIIb with stromal-derived fibroblast growth factor-7
17. Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism
18. Expression and immunochemical analysis of rat and human fibroblast growth factor receptor (flg) isoforms
19. Cloning of a fibroblast growth factor receptor i splice variant from Xenopus embryos that lacks a protein kinase C site important for the regulation of receptor activity
20. Identification of the cytoplasmic regions of fibroblast growth factor (FGF) receptor 1 which play important roles in induction of neurite outgrowth in PC12 cells by FGF-1
21. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins
22. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors
23. Purification and characterization of a newly identified growth factor specific for epithelial cells