Functional studies on the wilson copper P-Type ATPase and toxic milk mouse mutant

Biochemical and Biophysical Research Communications

Volumn 281, Issue 4, 2001, Pages 966-970

  Voskoboinik, I ^a   Greenough, M ^c   La Fontaine, S ^b   Mercer, J F B ^b   Camakaris, J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b DEAKIN UNIVERSITY   (Australia)

^c NONE

Author keywords

Copper; Heavy metals; P type ATPase; Toxic milk mouse; Wilson disease

Indexed keywords

ADENOSINE TRIPHOSPHATASE; COPPER; M PROTEIN; METHIONINE; UNCLASSIFIED DRUG; VALINE; WILSON PROTEIN;

ANIMAL CELL; ARTICLE; CATALYSIS; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE MUTATION; GENETIC TRANSFECTION; HOMEOSTASIS; MOUSE MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; WILSON DISEASE;

MAMMALIA;

EID: 0034810883     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4445     Document Type: Article

References (24)

1. The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene
2. The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene
3. Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease
4. Copper pumping ATPases: Common concepts in bacteria and man
5. Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: A novel mechanism of regulated trafficking
6. Hepatocyte-specific localization and copper-dependent trafficking of the Wilson's disease protein in the liver
7. Localization of the Wilson's disease protein in human liver
8. Mapping of the mouse homologue of the Wilson disease gene to mouse chromosome 8
9. The toxic milk mutation, tx, which results in a condition resembling Wilson disease in humans, is linked to mouse chromosome 8
10. Morphologic and chemical studies on a murine mutation (toxic milk mice) resulting in hepatic copper toxicosis
11. The toxic milk mouse is a murine model of Wilson disease
12. Functional analysis of the N-terminal CXXC metal-binding motifs in the human Menkes copper-transporting P-type ATPase expressed in cultured mammalian cells
13. ATP-dependent copper transport by the Menkes protein in membrane vesicles isolated from cultured CHO cells
14. A rapid and sensitive method for the quantitation of microgram quantities of protein utilising the principle of protein-dye binding
15. Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux
16. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
17. Molecular mechanisms of copper homeostasis
18. CopA: An Escherichia coli Cu(I)-translocating P-type ATPase
19. Functional characterization of missense mutations in ATP7B: Wilson disease mutation or normal variant?
20. Biochemical characterization of the Wilson disease protein and functional expression in the yeast Saccharomyces cerevisiae
21. The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake
22. Copper-induced apical trafficking of ATP7B in polarized hepatoma cells provides a mechanism for biliary copper excretion
23. Defective localization of the Wilson disease protein (ATP7B) in the mammary gland of the toxic milk mouse and the effects of copper supplementation