Reduction of Cr (VI) by cysteine: Significance in human lymphocytes and formation of DNA damage in reactions with variable reduction rates

Molecular and Cellular Biochemistry

Volumn 222, Issue 1-2, 2001, Pages 107-118

  Quievryn, George ^a   Goulart, Margarida ^a   Messer, Joseph ^a   Zhitkovich, Anatoly ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Chromium; Cysteine; DNA adduct; DNA damage; Glutathione; Welders

Indexed keywords

CHROMIUM; CHROMIUM DERIVATIVE; CYSTEINE; DNA; GLUTATHIONE; STAINLESS STEEL; THIOL;

ANALYSIS; ARTICLE; CELL METABOLISM; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROSS LINKING; DNA ADDUCT; DNA DAMAGE; DNA STRAND BREAKAGE; ELECTRON; GENOTOXICITY; HUMAN; HUMAN CELL; MALE; METAL METABOLISM; MUTAGENICITY; OCCUPATIONAL EXPOSURE; OXIDATION; PERIPHERAL LYMPHOCYTE; PROTEIN DNA INTERACTION; REDUCTION; WELDING; WELDING FUME;

CHROMIUM; CYSTEINE; DNA ADDUCTS; DNA DAMAGE; FLUORESCEINS; GLUTATHIONE; HUMANS; KINETICS; LYMPHOCYTES; MALE; OXIDATION-REDUCTION;

EID: 0034808208     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1017923609175     Document Type: Article

References (40)

1. Lung cancer mortality in nickel/chromium platers, 1946-1995
2. Chromium as an industrial carcinogen
3. One hundred years of chromium and cancer: Review of epidemiological evidence and selected case reports
4. Comparison of the localization of chromosome damage induced by calcium chromate and nickel compounds
5. Role of valence state and solubility of chromium compounds on induction of cytotoxicity, mutagenesis and anchorage independence in diploid human fibroblasts
6. Clastogenicity and mutagenicity of hexavalent chromium in lacZ transgenic mice
7. Role of free radicals in metal-induced carcinogenesis
8. Metal carcinogenesis: Mechanistic implications
9. Comparison of DNA lesions and cytotoxicity induced by calcium chromate in human, mouse, and hamster cell lines
10. Analysis of the induction of alkali sensitive sites in the DNA by chromate and other agents that induce single strand breaks
11. Chromium (VI) treatment of normal human lung cells results in guanine-specific DNA polymerase arrest, DNA-DNA crosslinks and S-phase blockage of cell cycle
12. Analysis of DNA-protein complexes induced by chemical carcinogens
13. Utilization of DNA-protein crosslinks as a biomarker of chromium exposure
14. Glutathione and free amino acids form stable complexes with DNA following exposure of intact mammalian cells to chromate
15. Formation of the amino acid-DNA complexes by hexavalent and trivalent chromium in vitro: Importance of trivalent chromium and the phosphate group
16. Chromium (V)-induced cleavage of DNA: Are chromium (V) complexes the active carcinogens in chromium (VI)-induced cancers?
17. Oxidative damage of DNA by chromium (V) complexes: Relative importance of base versus sugar oxidation
18. Formation of modified cleavage termini from the reaction of chromium (V) with DNA
19. Cr (IV) causes activation of nuclear transcription factor-kappa B, DNA strand breaks and dG hydroxylation via free radical reactions
20. Reductive metabolism of Cr (VI) by cysteine leads to the formation of binary and ternary Cr-DNA adducts in the absence of oxidative DNA damage
21. In vivo effects of ascorbate and glutathione on the uptake of chromium, formation of chromium (V), chromium-DNA binding and 8-hydroxy-2′-deoxyguanosine in liver and kidney of Osteogenic Disorder with chromium (VI)
22. Cr (III)-mediated crosslinks of glutathione or amino acids to the DNA phosphate backbone are mutagenic in human cells
23. Induction of mutagenic DNA damage by chromium (VI) and glutathione
24. Non-oxidative mechanisms are responsible for the induction of mutagenesis by reduction of Cr (VI) with cysteine: The role of ternary DNA adducts in Cr (III)-dependent mutagenesis
25. Metabolism of the carcinogen chromate by cellular constituents
26. Reduction of hexavalent chromium by ascorbic acid and glutathione with special reference to the rat lung
27. Studies on the kinetics of the reduction of chromate by glutathione and related thiols
28. EPR study on the interaction of hexavalent chromium with glutathione or cysteine: Production of pentavalent chromium and its stability
29. Reaction of Cr (VI) with ascorbate produces chromium (V), chromium (IV), and carbon-based radicals
30. Chromate-mediated free radical generation from cysteine, penicillamine, hydrogen peroxide, and lipid hydroperoxides
31. Loss of DNA-protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function
32. A simple, sensitive assay to detect DNA-protein crosslinks in intact cells and in vivo
33. Hypervalent chromium mimics reactive oxygen species as measured by the oxidant-sensitive dyes 2′, 7′-dichlorofluorescin and dihydrorhodamine
34. Novel reagents for chemical cleavage at abasic sites and UV photoproducts in DNA
35. Specific nicking of DNA at apurinic sites by peptides containing aromatic residues
36. Elevated DNA single-strand breakage frequencies in lymphocytes of welders exposed to chromium and nickel
37. Stoichiometry, kinetics, and mechanisms of the chromium (VI) oxidation of L-cysteine
38. Thiol status and cytopathological effects of acrolein in normal and xeroderma pigmentosum skin fibroblasts
39. Metal complexes of glutathione and their biological significance
40. Differential binding of chromium (VI) and chromium (III) complexes to salmon sperm nuclei and nuclear DNA and isolated calf thymus DNA