Utilization of DNA-protein cross-links as a biomarker of chromium exposure

Environmental Health Perspectives

Volumn 106, Issue SUPPL. 4, 1998, Pages 969-974

  Zhitkovich, Anatoly ^a,b   Voitkun, Victoria ^a,b   Kluz, Tomasz ^a   Costa, Max ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

Biomarker; Chromium; DNA adducts; DNA protein cross links; Mutagenesis

Indexed keywords

BIOLOGICAL MARKER; CHROMIUM; GLUTATHIONE;

CONFERENCE PAPER; DNA ADDUCT; ENVIRONMENTAL EXPOSURE; ERYTHROCYTE; HUMAN; LYMPHOCYTE; LYMPHOID CELL; POLLUTION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION;

EID: 0031684548     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.98106s4969     Document Type: Conference Paper

References (54)

1. IARC. Monograph on the Evaluation of Carcinogenic Risk to Humans. Vol 49: Chromium, Nickel and Welding. Lyon: International Agency for Research on Cancer, 1990.
2. Langardc S. One hundred years of chromium and cancer: a review of epidemiological evidence and selected case reports. Am J Ind Med 17: 189-215 (1990).
3. DeFlora S, Wetterhahn KE. Mechanisms of chromium metabolism and genotoxicity. Life Chem Rep 7: 169-744 (1989).
4. DeFlora S, Bagnasco M, Serra D, Zanacchi P. Genotoxicity of chromium compounds: 4 review. Mutat Res 238: 99-172 (1990).
5. Snow E. Metal carcinogenesis: mechanistic implications. Pharmacol Ther 53: 31-65 (1992).
6. Alexander J, Aaseth J. Uptake of chromate in human red blood cells and isolated rat liver cells: the role of the anion carrier. Analyst 120: 931-933 (1995).
7. ?.. Sehlmeyer U, Hetchtenberg S, Klyszcz H, Beyersmann D. Accumulation of chromium in Chinese hamster V79-cells and nuclei. Arch Toxicol 64: 506-508 (1990).
8. Connett PU, Wetterhahn KE. Metabolism of the carcinogen chromate by cellular constituents. Struct Bonding 54: 93-124 (1983).
9. Dillon CT, Lay PA, Cholewa M, Legge GJF, Bonin AM, Collins TJ, Kostka KL, She-McCarthy G. Microprobe X-ray absorption spectroscopic determination of the oxidation state of intracellular chromium following exposure of V79 Chinese hamster lung cells to genotoxic chromium complexes. Chem Res Toxicol 10: 533-535 (1997).
10. Lewalter J, Korallus U, Weidemann H. Chromium bond detection in isolated erythrocytes: A new principle of biological monitoring of exposure to hexavalent chromium. Int Arch Occup Environ Health 55: 305-318 (1985).
11. 1. O'Brien P, Barret J, Swanson F. Chromium (V) can be generated in the reduction of chromium (VI) by glutathione. Inorg Chim Acta 108: L19-L20 (1985).
12. Goodgame DML, Joy MA. EPR study of the Cr(V) and radical species produced in the reduction of Cr(VI) by ascorbate. Inorg Chim Acta 135: 115-118 (1987).
13. Aiyar J, Berkovits HJ, Floyd RA, Wetterhahn KE. Reaction of chromium(VI) with hydrogen peroxide in the presence of glutathione: reactive intermediates and resulting DNA damage. Chem Res Toxicol 3: 595-603 (1990).
14. Stearns DM, Wetterhahn KE. Reacrion of Cr(VI) with ascorbate produces chromium(V), chromium(IV), and carbon-based radicals. Chem Res Toxicol 7: 219-230 (1994).
15. Suzuki Y, Fukuda K. Reduction of hexavalent chromium by ascorbic acid and glutathione with special reference to the rat lung. Arch Toxicol 64: 169-176 (1990).
16. Standeven AM, Wetterhahn KE. Ascorbate is the principal reductant of chromium(VI) in rat lung ultrafiltrates and cytosols, and mediates chromium-DNA binding in vitro. Carcinogenesis 13: 1319-1324 (1992).
17. Wedrychowski A, Ward SW, Schmidt WN, Hnilica LS. Chromium-induced cross-linking of nuclear proteins and DNA. J Biol Chem 260: 7150-7155 (1985).
18. Voitkun V, Zhitkovich A, Costa M. Complexing of amino acids to DNA by chromate in intact cells. Environ Health Perspect 102(Suppl 3): 251-255 (1994).
19. Zhitkovich A, Voitkun V, Costa M. Glutathione and free amino acids form stable complexes with DNA following exposure of intact mammalian cells to chromate. Carcinogenesis 16: 907-913(1995),
20. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Chromium. Washington: U.S. Department of Health and Human Services, 1993.
21. Stern AH, Freeman NCG, Plevan P, Boesch RR, Wainman T, Howell T, Shupack SI, Johnson BB, Lioy PJ. Residential exposure co chromium waste-urine biological monitoring in conjunction with environmental exposure monitoring. Environ Res 58: 147-162 (1992).
22. Burke T, Fagliano J, Goldoft M, Hazen RE, Iglewicz R, McKee T. Chromite ore processing residue in Hudson County, New Jersey. Environ Health Perspect 92: 131-138 (1991).
23. Freeman NCG, Stern AH, Lioy PJ. Exposure to chromium dust from homes in a chromium surveillance project. Arch Environ Health 52: 213-219 (1997).
24. Bonde JP, Christensen JM. Chromium biological samples from low-level exposed stainless steel and mild steel welders. Arch Environ Health 46: 225-229 (1991).
25. Kilburn KH, Warshaw R, Boylen T, Thornton JC, Hopfer SM, Sunderman WF Jr, Finklea J. Cross-shift and chronic effects of stainless steel welding related to internal dosimetry of chromium and nickel. Am J Ind Med 17: 607-615 (1990).
26. Stridsklev IC, Hemmingsen B, Karlsen JT, Schaller KH, Raithel HJ, Langard S. Biologic monitoring of chromium and nickel among stainless steel welders using the manual metal are method. Int Arch Occup Environ Health 65: 209-219 (1993).
27. Anderson RA, Polansky MM, Bryden NA, Roginski EE, Patterson KY, Veillon C, Glinsmann W. Urinary chromium excretion of human subjects: effect of chromium supplementation and glucose loading. Am J Clin Nutr 36: 1184-1193 (1982).
28. Anderson RA, Bryden NA, Polansky MM. Serum chromium of human subjects: effect of chromium supplementation and glucose. Am J Clin Nutr 41: 571-577 (1985).
29. Kortenkamp A, Beyersmann D, O'Brien P. Uptake of Cr(III) complexes by erythrocytes. Toxicol Environ Chem 14: 23-32 (1987).
30. Elias Z, Mur J-M, Pierre F, Gilgenkrantz S, Schneider O, Baruthio F, Daniere M-C, Fontana J-M. Chromosome aberrations in peripheral blood lymphocytes of welders and characterization of their exposure by biological samples analysis. J Occup Med 31: 477-483 (1989).
31. Nagaya T, Ishikawa N, Hata H, Otobe T. Sister-chromatid exchanges in lymphocytes from 12 chromium platers: a 5-year follow-up study. Toxicol Lett 58: 329-335 (1991).
32. Knudsen LK, Boisen T, Christensen JM, Jelnes JR, Jensen GE, Jensen JC, Lundgren K, Lundsteen C, Pedersen B, Wassermann K, et al. Biomonitoring of genotoxic exposure among stainless steel welders. Mutat Res 279: 129-143 (1992).
33. Jelmert O, Hansteen IL, Langard S. Cytogenetic studies of stainless steel welders using the tungsten inert gas and metal inert gas methods for welding. Mutat Res 342: 77-85 (1995).
34. Zhitkovich A, Costa M. A simple, sensitive assay to detect DNA-protein-crosslinks in intact cells and in vivo. Carcinogenesis 13: 1485-1489 (1992).
35. Coogan TP, Motz J, Snyder CA, Squibb KS, Costa M. Differential DNA-protein crosslinking in lymphocytes and liver following chronic drinking water exposure of rats to potassium chromate. Toxicol Appl Pharmacol 109: 60-72 (1991).
36. Taíoli E, Kinney P, Zhitkovich A, Fulton H, Voitkun V, Cosma G, Frenkel K, Toniolo P, Garte S, Costa M. Application of reliability models to studies of biomarker validation. Environ Health Perspect 102: 306-309 (1994).
37. Costa M, Zhitkovich A, Gargas M, Paustenbach D, Finlcy B, Kuykendall J, Billings R, Carkon T, Wettcrhahn K, Xu J, er al. Interlaboratory validation of a new assay for DNA-protein crosslinks. Mutat Res 369: 13-21 (1996).
38. Olin KL, Cherr GN, Rifkin E, Keen CL. The effects of some redox-active metals and reactive aldehydes on DNA-protein cross-links in vitro. Toxicology 110: 1-8 (1996).
39. Costa M, Zhitkovich A, Harris M, Paustenbauch D, Gargas M. DNA-protein crosslinks produced by various chemicals in cultured human lymphoma cells. J Toxicol Environ Health 50: 101-116(1997).
40. Costa M, Zhitkovich A, Toniolo P. DNA-protein crosslinks in welders: molecular implications. Cancer Res 53: 460-463 (1993).
41. Popp W, Vahrenholtz C, Schimieding W, Krewet E, Norpoth K. Investigations of the frequency of DNA strand breakage and cross-linking and of sister chromatid exchanges in the lymphocytes of electric welders exposed to chromium- and nickel-conlaining fumes. Int Arch Occup Environ Health 63: 115-120 (1991).
42. Werfel U, Langen V, Eickhoff I, Schoonbrood J, Vahrenholtz C, Brauksiepe A, Popp W, Norpoth K. Elevated DNA singlestrand breakage frequencies in lymphocytes of welders exposed to chromium and nickel. Carcinogcnesis 19: 413-418 (1998).
43. Zhitkovich A, Lukanova A, Popov T, Taioli E, Cohen H, Cnsta M, Toniolo P. DNA-protein crosslinks in peripheral lymphocytes of individuals exposed to hexavalent chromium compounds. Biomarkers 1: 86-93 (1996).
44. Taioli E, Zhitkovich A, Kinney P, Udasin I, Toniolo P, Costa M. Increased DNA-protein crosslinks in lymphocytes of residents living in chromium contaminated areas. Biol Trace Element Res 50: 175-180 (1995).
45. Taioli E, Zhitkovich A, Toniolo P, Costa M. Normal values of DNA-protein crosslinks in mononuclear cells of a population of healthy controls. Cancer J 8: 76-78 (1995).
46. Oesch F, Hengstler JG, Fuchs J. Cigarette smoking protects mononuclear blood cells of carcinogen exposed workers from additional work exposure-induced DNA single strand breaks. Mutat Res 321: 175-185 (1994).
47. Parris CM, Seidman MM. A signature clement distinguishes sibling and independent mutations in a shuttle vector plasmid. Gene 117: 1-5 (1992).
48. Ariza RR, Roldan-Arjona T, Hera C, Pueyo C. A method for selection of forward mutations in supF gene carried by shuttlevector plasmids. Carcinogenesis 14: 303-305 (1993).
49. Salnikow K, Zhitkovich A, Costa M. Analysis of the binding sites of chromium to DNA and protein in vitro and in intact cells. Carcinogenesis 13: 2341-2346 (1992).
50. Zhitkovich A, Voitkun V, Costa M. Formation of the amino acid-DNA complexes by hexavalent and trivalent chromium in vitro; importance of trivalent chromium and the phosphate group. Biochemistry 35: 7275-7282 (1996).
51. Voitkun V, Zhitkovich A, Costa M. Cr(III)-mediated crosslinks of glutathione or amino acids to the DNA phosphate backbone are mutagcnic in human cells. Nucl Acids Res 26: 2024-2030 (1998).
52. Brazilian HE, Schmid E, Bauchinger M. Chromosome aberrations in nuclear power plant workers: the influence of dose accumulation and lymphocyte life-time. Mutat Res 306: 197-202 (1994).
53. Blankenship LJ, Manning FCR, Orenstein JM, Patierno SR. Apoptosis is the mode of cell death caused by carcinogenic chromium. Toxicol Appl Pharmacol 126: 75-83 (1994).
54. Blankenship IJ, Carlisle DL, Wise JP Sr, Orenstein JM, Dye LE III, Patierno SR. Induction of apoptotic cell death by particulate lead chromatc: differential effects of vitamins C and E on genotoxicity and survival. Toxicol Appl Pharmacol 146: 270-280 (1997).