Transient increase of monocyte adhesion after a single dose of simvastatin

Atherosclerosis

Volumn 158, Issue 2, 2001, Pages 491-493

  Erl, Wolfgang ^a   Weber, Kim S C ^a   Weber, Peter C ^a   Weber, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Atherosclerosis; HMG CoA reductase inhibitors; Short term treatment

Indexed keywords

DRUG METABOLITE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO; PRAVASTATIN; PRODRUG; SIMVASTATIN;

ARTICLE; CELL ADHESION; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG METABOLISM; HUMAN; HYPERCHOLESTEROLEMIA; LONG TERM CARE; MALE; MONOCYTE; PERIPHERAL CIRCULATION; PRIORITY JOURNAL;

CELL ADHESION; CELLS, CULTURED; CHOLESTEROL; ENDOTHELIUM, VASCULAR; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; MALE; MONOCYTES; SIMVASTATIN; UMBILICAL VEINS;

EID: 0034808092     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(01)00448-8     Document Type: Article

References (7)

1. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
2. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
3. Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions
4. Statins do more than just lower cholesterol
5. HMG-CoA reductase inhibitors decrease CDllb expression and CDllb-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia
6. Short-term pravastatin mediates growth inhibition and apoptosis, independently of Ras, via the signaling proteins p27Kipl and P13 kinase
7. Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s)