Differential adrenomedullin release and endothelin receptor expression in distinct subpopulations of human airway smooth-muscle cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 25, Issue 3, 2001, Pages 316-325

  Upton, P D ^a   Wharton, J ^a   Davie, N ^a   Ghatei, M A ^a   Smith, D M ^a   Morrell, N W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHUS; EUKARYOTA;

EID: 0034807935     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.25.3.4399     Document Type: Article

References (39)

1. Functional significance of increased airway smooth muscle in asthma and COPD
2. Potential role for phenotypic modulation of bronchial smooth muscle cells in chronic asthma
3. Contractile effects and receptor distributions for endothelin-1 (ET-1) in human and animal airways
4. Functional and autoradiographic studies of endothelin-1 and endothelin-2 in human bronchi, pulmonary arteries, and airway parasympathetic ganglia
5. Endothelin-1-induced potentiation of human airway smooth muscle proliferation: An ETA receptor-mediated phenomenon
6. Immunoreactive endothelin in bronchial biopsy specimens: Increased expression in asthma and modulation by corticosteroid therapy
7. Localization of immunoreactive endothelin and proendothelin in the human lung
8. Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction
9. Endothelin-1 receptor density, distribution, and function in human isolated asthmatic airways
10. Endothelin receptor distribution and function in the airways
11. Necessity of dual blockade of endothelin ETA and ETB receptor subtypes for antagonism of endothelin-1-induced contraction in human bronchi
12. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
13. Pulmonary vasodilation to adrenomedullin: A novel peptide in humans
14. Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats
15. Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma
16. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin
17. Adrenomedullin, a newly discovered hypotensive peptide is a potent bronchodilator
18. Expression of adrenomedullin in normal human lung and in pulmonary tumors
19. An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat
20. Inhibition of endothelin production by adrenomedullin in vascular smooth muscle cells
21. Effects of vasoactive substances and cAMP related compounds on adrenomedullin production in cultured vascular smooth muscle cells
22. Autocrine role for the endothelin-B receptor in the secretion of adrenomedullin
23. Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities
24. Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity
25. Autoradiographic localization of endothelin-1 binding sites in the cardiovascular and respiratory systems
26. Circulating adrenomedullin does not regulate systemic blood pressure but increases plasma prolactin after intravenous infusion in humans: A pharmacokinetic study
27. Characterization and molecular identification of adrenomedullin binding sites in the rat spinal cord: A comparison with calcitonin gene-related peptide receptors
28. Presence of immunoreactive endothelin in human milk
29. ET-1 induces mitogenesis in ovine airway smooth muscle cells via ETA and ETB receptors
30. Ca2+ signalling by endothelin receptors in rat and human cultured airway smooth muscle cells
31. Altered ETB- but not ETA-receptor density and function in sheep airway smooth muscle cells in culture
32. Airway smooth muscle cell proliferation: Characterization of subpopulations by sensitivity to heparin inhibition
33. Phenotypic diversity and molecular mechanisms of airway smooth muscle proliferation in asthma
34. Regulation of adrenomedullin production in rat endothelial cells
35. Adrenomedullin as a novel antiproliferative factor of vascular smooth muscle cells
36. Characterization of endothelin receptor subtypes on airway smooth muscle cells
37. BQ123, an ETA receptor antagonist, inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells
38. The selective endothelin ETA receptor antagonist BQ123 antagonizes endothelin-1-mediated mitogenesis
39. Inhibition by salbutamol of the proliferation of human airway smooth muscle cells grown in culture