Infections with non-tuberculous mycobacteria and salmonellae in patients with genetic defects in the interleukin-12/interferon-γ-mediated pathway of macrophage activation

Netherlands Journal of Medicine

Volumn 59, Issue 3, 2001, Pages 90-94

  Van Dissel, J T ^a   Arend, S M ^a   Ottenhoff, T H M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Cytokines; Genetics; Interferon gamma; Mycobacteria; Receptors; Susceptibility

Indexed keywords

ANTIBIOTIC AGENT; CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 18; INTERLEUKIN 2; PROTEIN P35; RECEPTOR SUBUNIT; STAT1 PROTEIN; STAT4 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN SPECIFICITY; ANTIMICROBIAL THERAPY; BACTERIAL VIRULENCE; BCG VACCINATION; CELLULAR IMMUNITY; CYTOKINE RELEASE; DISEASE COURSE; DISEASE SEVERITY; EDITORIAL; ENVIRONMENTAL FACTOR; GENETIC POLYMORPHISM; HISTOPATHOLOGY; HUMAN; HUMORAL IMMUNITY; IMMUNE DEFICIENCY; INFECTION SENSITIVITY; LEPROMATOUS LEPROSY; MACROPHAGE ACTIVATION; MYCOBACTERIOSIS; MYCOBACTERIUM TUBERCULOSIS; PROTEIN DEFECT; RISK FACTOR; SALMONELLOSIS; TUBERCULIN TEST;

ADOLESCENT; ADULT; AGE DISTRIBUTION; CAUSALITY; CHILD; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; MACROPHAGE ACTIVATION; MUTATION; MYCOBACTERIUM INFECTIONS; SALMONELLA INFECTIONS;

EID: 0034807743     PISSN: 03002977     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-2977(01)00147-4     Document Type: Editorial

References (14)

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3. Novel human immunodeficiencies reveal the essential role of type-I cytokines in immunity to intracellular bacteria
4. Human deficiencies in type 1 cytokine receptors reveal the essential role of type 1 cytokines in immunity to intracellular bacteria
5. Clinical consequences of defects in the IL-12-dependent interferon-gamma (IFN-γ) pathway
6. Multifocal osteomyelitis caused by nontuberculous mycobacteria in patients with a genetic defect of the interferon-γ receptor
7. A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection
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10. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
11. Residual type 1 immunity in patients genetically deficient for interleukin 12 receptor β1 (IL-12Rβ1): Evidence for an IL-12Rβ1-independent pathway of IL-12 responsiveness in human T cells
12. Functional diversity of helper T lymphocytes