Protein kinase A modulates spontaneous activity in chronically compressed dorsal root ganglion neurons in the rat

Pain

Volumn 94, Issue 1, 2001, Pages 39-46

  Hu, San Jue ^a   Song, Xue Jun ^a   Greenquist, Kenneth W ^a   Zhang, Jun Ming ^a   LaMotte, Robert H ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dorsal root ganglion; Neuropathic pain; Protein kinase A; Spontaneous activity

Indexed keywords

ADENYLATE CYCLASE ACTIVATOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP DERIVATIVE; FORSKOLIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; RP CYCLIC AMP; SP CYCLIC AMP; STAINLESS STEEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; IN VITRO STUDY; LUMBAR SPINAL CORD; MALE; MICROFILAMENT; MODULATION; MYELINATED NERVE; NERVE CELL INHIBITION; NERVE COMPRESSION; NERVE CONDUCTION; NERVE POTENTIAL; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SPINAL GANGLION;

ACTION POTENTIALS; ANIMALS; CHRONIC DISEASE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; GANGLIA, SPINAL; MALE; NERVE COMPRESSION SYNDROMES; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; THIONUCLEOTIDES;

EID: 0034807327     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(01)00339-6     Document Type: Article

References (55)

1. Role of protein kinase A in the maintenance of inflammatory pain
2. cAMP analog antagonists of cAMP action
3. Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain
4. Three types of sodium channels in adult rat dorsal root ganglion neurons
5. Myelinated afferents signal the hyperalgesia associated with nerve injury
6. Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons
7. The capsaicin receptor: A heat-activated ion channel in the pain pathway
8. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H89) of PC12D pheochromocytoma cells
9. Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain
10. Pathophysiology of damaged nerves in relation to chronic pain
11. Eicosanoids but not tachykinins excite C-fiber endings in rat sciatic nerve-end neuromas
12. Neuropathic pain from an experimental neuritis of the rat sciatic nerve
13. PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade
14. The cAMP transduction cascade mediates the PGE2-induced inhibition of potassium currents in rat sensory neurones
15. Reduction in potassium currents in identified cutaneous afferent dorsal root ganglion neurons after axotomy
16. Morphologically identified cutaneous afferent DRG neurons express three different potassium currents in varying proportions
17. 2+ dependent process
18. cAMPamp-dependent phosphorylation of the tetrodoxin-resistant voltage-dependent sodium channel SNS
19. 2+ influx in visceral afferent neurons
20. + current in nociceptors
21. 2-induced sensitization of cultured rat sensory neurons
22. Unresponsive afferent nerve fibers in the sural nerve of the rat
23. Prostaglandins facilitate peptide release from rat sensory neurons by activating the adenosine 3′,5′-cyclic monophosphate transduction cascade
24. An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat
25. Inhibition of spinal protein kinase C reduces nerve injury-induced tactile allodynia in neuropathic rats
26. h via adenylyl cyclase
27. Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat
28. Altered excitability of large-diameter cutaneous afferents following nerve injury: Consequences for chronic pain
29. Dynamic and static components of mechanical hyperalgesia in human hairy skin
30. Cutaneous sensory receptors in the rat foot
31. Tactile allodynia in the absence of C-fiber activation: Altered firing properties of DRG neurons following spinal nerve injury
32. The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons: Whole-cell and single-channel studies
33. Progressive tactile hypersensitivity: An inflammation-induced incremental increase in the excitability of the spinal cord
34. Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase
35. Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity
36. Axotomy results in major changes in BDNF expression by dorsal root ganglion cells: BDNF expression in large trkB and trkC cells in pericellular baskets and in projections to deep dorsal horn and dorsal column nuclei
37. Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons
38. + current underlying the slow spike frequency adaptation in hippocampal neurons
39. Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block
40. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3′5′-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase
41. Mechanoreceptors in rat glabrous skin: Redevelopment of function after nerve crush
42. Variation IH, IIR, and ILEAK between acutely isolated adult rat dorsal root ganglion neurons of different size
43. Neurogenic hyperalgesia: Central neural correlates in responses of spinothalamic tract neurons
44. Excitation of dorsal root ganglion cells by inflammatory mediators and glutamate in nerve-injured rat
45. Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia
46. Mediation of primary afferent peripheral hyperalgesia by the cAMP second messenger system
47. Central changes in processing of mechanoreceptive input in capsaicin-induced secondary hyperalgesia in humans
48. Sensory afferent impulse originate from dorsal root ganglia as well as from the periphery in normal and nerve injury rats
49. Ongoing activity in peripheral nerves: The physiology and pharmacology of impulses originating from a neuroma
50. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases
51. Sodium channels and pain
52. Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat
53. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion
54. Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion
55. Response characteristics of fibers in regenerating and regenerated cutaneous nerves in cat and rat