Recombinant canine IL-13 receptor α2-Fc fusion protein inhibits canine allergen-specific-IgE production in vitro by peripheral blood mononuclear cells from allergic dogs

Veterinary Immunology and Immunopathology

Volumn 83, Issue 1-2, 2001, Pages 115-122

  Tang, Liang ^a   Boroughs, Karen L ^a   Morales, Tony ^a   Stedman, Kim ^a   Sellins, Karen ^a   Clarke, Katie ^a   McDermott, Martin ^a   Yang, Shumin ^a   McCall, Catherine ^a  

^a HESKA CORPORATION   (United States)

Author keywords

Canine atopy; IgE; IL 13; IL 13 receptor

Indexed keywords

HYBRID PROTEIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; INTERLEUKIN 13 RECEPTOR; RECOMBINANT INTERLEUKIN 13; RECOMBINANT PROTEIN;

ALLERGIC DISEASE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DOG; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROLEUKEMIA CELL; ESCHERICHIA COLI; GENE CONSTRUCT; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; INSECT ALLERGY; MONONUCLEAR CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; DOG DISEASES; DOGS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; FLEAS; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; INTERLEUKIN-13; INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT; LEUKOCYTES, MONONUCLEAR; MOLECULAR SEQUENCE DATA; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-13; RECOMBINANT FUSION PROTEINS; SEQUENCE ANALYSIS, DNA; TUMOR CELLS, CULTURED;

EID: 0034805187     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(01)00378-6     Document Type: Article

References (26)

1. Reconstitution of a functional human type II IL-4/IL-13 receptor in mouse B cells: demonstration of species specificity
2. Immunoadhesins as research tools and therapeutic agents
3. Activated mast cells produce interleukin 13
4. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain
5. Immunoadhesins: principles and applications
6. IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
7. Interleukin-4 and interleukin-13: their similarities and discrepancies
8. IL-13 in allergy: home at last
9. Induction and regulation of the IgE response
10. Interleukin 13 is a B cell stimulating factor
11. Differential regulation of IL-13 and IL-4 production by human CD8+ and CD4+ Th0, Th1 and Th2 T cell clones and EBV-transformed B cells
12. The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1
13. Requirement for IL-13 independently of IL-4 in experimental asthma
14. Mouse IL-13 enhances antibody production in vivo and acts directly on B cells in vitro to increase survival and hence antibody production
15. Identification, cloning, and characterization of a major cat flea salivary allergen (Cte f 1)
16. The related cytokines interleukin-13 and interleukin-4 are distinguished by differential production and differential effects on T lymphocytes
17. IL-13 induces proliferation, Ig isotype switching, and Ig synthesis by immature human fetal B cells
18. Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor
19. Measurement of canine IgE using the alpha chain of the human high affinity IgE receptor
20. Molecular cloning of canine IL-13 receptor α chain (α1 and α2) cDNAs and detection of corresponding mRNAs in canine tissues
21. Cloning and characterization of cDNAs encoding four different canine immunoglobulin ( chains
22. Interleukin-13: central mediator of allergic asthma
23. Canine interleukin-13: molecular cloning of full-length cDNA and expression of biologically active recombinant protein
24. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction