Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family

DNA and Cell Biology

Volumn 20, Issue 8, 2001, Pages 493-498

  Bonvouloir, Nadia ^a   Crine, Philippe ^a   Boileau, Guy ^a   DesGroseillers, Luc ^a   Lemieux, Nicole ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; FURIN; ISOPROTEIN; MEMBRANE METALLOENDOPEPTIDASE; MEMBRANE METALLOENDOPEPTIDASE LIKE 2 PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 1P; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENETIC CODE; GENETIC DISORDER; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; HUMAN TISSUE; MOLECULAR CLONING; NEUROBLASTOMA; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN SECRETION; PROTEIN STRUCTURE; SCHWARTZ JAMPEL SYNDROME; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 1; CLONING, MOLECULAR; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION; HUMANS; MALE; MOLECULAR SEQUENCE DATA; NEPRILYSIN; SEQUENCE HOMOLOGY, AMINO ACID; TESTIS; TISSUE DISTRIBUTION;

EID: 0034803572     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454901316976127     Document Type: Article

References (27)

1. Evidence that both arginine 102 and arginine 747 are involved in substrate binding to neutral endopeptidase (EC 3.4.24.11)
2. Localization of a gene (CMT2A) for autosomal dominant Charcot-Marie-Tooth disease type 2 to chromosome 1p and evidence of genetic heterogeneity
3. Endopeptidase-24.11
4. Localization of a human double-stranded RNA-binding protein gene (STAU) to band 20q13.1 by fluorescence in situ hybridization
5. Kinetic evidence that His-711 of neutral endopeptidase 24.11 is involved in stabilization of the transition state
6. 2′ residue of substrates and inhibitors
7. Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family
8. Structure of thermolysin refined at 1.6 Å resolution
9. Families of zinc metalloproteases
10. Molecular identification and characterization of novel membrane-bound metalloprotease, the soluble secreted form of which hydrolyzes a variety of vasoactive peptides
11. Endopeptidase-24.11: Putative substrates and possible roles
12. Evidence by site-directed mutagenesis that arginine 203 of thermolysin and arginine 717 of neprilysin (neutral endopeptidase) play equivalent critical roles in substrate hydrolysis and inhibitor binding
13. Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1
14. Localization of the Schwartz-Jampel syndrome (SJS) locus to chromosome 1p34-p36.1 by homozygosity mapping
15. Structure of human neutral endopeptidas e (neprilysin) complexed with phosphoramidon
16. 39′ non-coding region sequences in eukaryotic messenger RNA
17. Suggestive linkage of developmental dyslexia to chromosome 1p34-p36
18. Proprotein and prohormone convertases: A family of subtilases generating diverse bioactive polypeptides
19. 412 with a similar catalytic mechanism and a distinct substrate binding mechanism compared with neutral endopeptidase-24.11
20. Neprilysin II: A putative novel metalloprotease and its isoforms in CNS and testis
21. Endothelin-converting enzymes
22. Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX
23. The neprilysin family in health and disease
24. Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)
25. Neuroblastoma consensus deletion maps to 1p36.1-2
26. A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3
27. Mammalian staufen is a double-stranded- RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum