The role of species-dependent metabolism in the regional brain retention of 18F-labeled muscarinic acetylcholine receptor ligands

Nuclear Medicine and Biology

Volumn 28, Issue 7, 2001, Pages 753-759

  Skaddan, Marc B ^a   Sherman, Phil S ^a   Kilbourn, Michael R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Fluorine 18; Ligands; Metabolites; Mouse; Muscarinic receptor; Rats

Indexed keywords

(2 FLUOROETHYL) 3 PIPERIDYLBENZILATE F 18; (2 FLUOROETHYL) 3 PYRROLIDYLBENZILATE F 18; (2 FLUOROETHYL) 4 PIPERIDYLBENZILATE F 18; ACETYLCHOLINE; BENZILIC ACID DERIVATIVE; BLOOD EXTRACT; BRAIN EXTRACT; FLUORINE 18; MUSCARINIC RECEPTOR; PIPERIDYLBENZILATE; PYRROLIDYLBENZILATE; RADIOLIGAND; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN REGION; CONTROLLED STUDY; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FEMALE; ISOTOPE LABELING; MALE; METABOLITE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RAT; SPECIES DIFFERENCE; TISSUE DISTRIBUTION;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CHOLINERGIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; HYDROLYSIS; ISOTOPE LABELING; LIGANDS; MALE; MICE; RADIOPHARMACEUTICALS; RATS; RECEPTORS, MUSCARINIC; SPECIES SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET; TISSUE DISTRIBUTION;

EID: 0034802906     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(01)00240-2     Document Type: Article

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