Hypermethylation of the CD44 gene is associated with progression and metastasis of human prostate cancer

Prostate

Volumn 49, Issue 2, 2001, Pages 110-115

  Kito, Hiroki ^a   Suzuki, Hiroyoshi ^a   Ichikawa, Tomohiko ^a   Kamiya, Nobuyuki Sekita Naoto ^a   Akakura, Koichiro ^a   Igarashi, Tatsuo ^a   Nakayama, Tsuyoshi ^a   Watanabe, Masatoshi ^a   Harigaya, Kenichi ^a   Ito, Haruo ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

CD44; Hypermethylation; Metastasis; Progression; Prostate cancer

Indexed keywords

HERMES ANTIGEN; RESTRICTION ENDONUCLEASE;

ARTICLE; CANCER GROWTH; CANCER RECURRENCE; CANCER STAGING; CPG ISLAND; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MALE; METASTASIS; METHYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; ANTIGENS, CD44; CPG ISLANDS; DNA METHYLATION; DNA, NEOPLASM; HUMANS; LYMPH NODES; MALE; MIDDLE AGED; NEOPLASM METASTASIS; POLYMERASE CHAIN REACTION; PROSTATIC NEOPLASMS; STATISTICS, NONPARAMETRIC; TUMOR CELLS, CULTURED;

EID: 0034799615     PISSN: 02704137     EISSN: None     Source Type: Journal    
DOI: 10.1002/pros.1124     Document Type: Article

References (29)

1. Altered expression of CD44 human prostate cancer during progression
2. The prognostic value of CD44 isoforms in prostate cancer patients treated by radical prostatectomy
3. CD44 and CD44v6 downregulation in clinical prostatic carcinoma: Relation to Gleason grade and cytoarchitecture
4. Decreased expression of CD44 in metastatic prostate cancer
5. CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 11p13
6. Methylation-induced repression-belts, braces, and chromatin
7. Epigenetic regulation of androgen receptor gene expression in human prostate cancers
8. Methylation of the androgen receptor minimal promoter silences transcription in human prostate cancer
9. E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas
10. Deletional, mutational, and methylation analyses of CDKN2 (p16/MTS1) in primary and metastatic prostate cancer
11. Methylation of the 5′ CpG island of the endothelin B receptor gene is common in human prostate cancer
12. Detailed methylation analysis of the glutathione S-transferase pi (GSTP1) gene in prostate cancer
13. Metastasis suppression by the standard CD44 isoform does not require the binding of prostate cancer cells to hyaluronate
14. Methylation of the CD44 metastasis suppressor gene in human prostate cancer
15. Down-regulation of CD44 expression in human prostatic carcinoma cell lines is correlated with DNA hypermethylation
16. Silencing of CD44 expression in prostate cancer by hypermethylation of the CD44 promoter region
17. Heterogeneity in intratumor distribution of p53 mutations in human prostate cancer
18. Intratumor cellular heterogeneity and alterations in ras oncogene and p53 tumor suppressor gene in human prostate carcinoma
19. DNA heterogeneity in prostatic adenocarcinoma. A DNA flow cytometric mapping study with whole organ sections of prostate
20. Allelic loss in locally metastatic, multisampled prostate cancer
21. Primary human prostate cancer cells harboring p53 mutations are clonally expanded in metastases
22. Chromosomal anomalies in stage D1 prostate adenocarcinoma primary tumors and lymph node metastases detected by fluorescence in situ hybridization
23. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues
24. LNCaP model of human prostatic carcinoma
25. Establishment and characterization of a human prostatic carcinoma cell line (PC-3)
26. Expression and modulation of CD44 variant isoforms in humans
27. CD44 variant exon epitopes in primary breast cancer and length of survival
28. Expression of CD44 variant proteins in human colorectal cancer is related to tumor progression
29. Expression of CD44 isoforms in renal cell tumors. Positive correlation to tumor differentiation