Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: Non-nucleoside HIV-1 reverse transcriptase inhibitors

Antiviral Chemistry and Chemotherapy

Volumn 12, Issue 3, 2001, Pages 169-174

  Chimirri, A ^a   Monforte, P ^a   Rao, A ^a   Zappala M ^a   Monforte, A M ^a   De Sarro, G ^a   Pannecouque, C ^a   Witvrouw, M ^a   Balzarini, J ^a   De Clercq, E ^a  

^a UNIVERSITY OF MESSINA   (Italy)

Author keywords

1H,3H oxazolo 3,4 a benzimidazoles; Anti HIV activity; NNRTIs

Indexed keywords

1H,3H OXAZOLO[3,4 A]BENZIMIDAZOLE DERIVATIVE; 1H,3H THIAZOLO[3,4 A]BENZIMIDAZOLE DERIVATIVE; ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; 1 (2 CHLORO 6 FLUOROPHENYL) 1H,3H OXAZOLO(3,4 A)BENZIMIDAZOLE; 1 (2,6 DIFLUOROPHENYL) 1H,3H OXAZOLO(3,4 A)BENZIMIDAZOLE; 1 PHENYL 1H,3H OXAZOLO(3,4 A)BENZIMIDAZOLE; 1-(2,6-DIFLUOROPHENYL)-1H,3H-OXAZOLO(3,4-A)BENZIMIDAZOLE; 1-(2-CHLORO-6-FLUOROPHENYL)-1H,3H-OXAZOLO(3,4-A)BENZIMIDAZOLE; 1-PHENYL-1H,3H-OXAZOLO(3,4-A)BENZIMIDAZOLE; HIV 1 REVERSE TRANSCRIPTASE; OXAZOLE DERIVATIVE; RNA DIRECTED DNA POLYMERASE;

ARTICLE; DRUG ACTIVITY; DRUG CONFORMATION; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS 1; INHIBITION KINETICS; MOLECULAR MODEL; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION; ANIMAL; BLOOD; CELL LINE; CHEMICAL STRUCTURE; DRUG EFFECT; ENZYMOLOGY; HUMAN; IC 50; PHYSIOLOGY; RAT; RAT STRAIN; SYNTHESIS;

ANIMAL; BENZIMIDAZOLES; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMAN; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; OXAZOLES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; VIRUS REPLICATION;

EID: 0034797941     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020101200304     Document Type: Article

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