Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of azidothymidine and 9-(R)-2-(phosphono methoxypropyl)adenine

Antiviral Chemistry and Chemotherapy

Volumn 12, Issue 3, 2001, Pages 151-159

  Franchetti, P ^a   Rossi, L ^a   Cappellacci, L ^a   Pasqualini, M ^a   Grifantini, M ^a   Balestra, E ^a   Forbici, F ^a   Perno, C F ^a   Serafini, S ^a   Magnani, M ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Azidothymidine (R) PMPA; Erythrocytes; HIV; Macrophages

Indexed keywords

DINUCLEOTIDE; GAG PROTEIN; PRODRUG; TENOFOVIR; UNCLASSIFIED DRUG; ZIDOVUDINE; ZIDOVUDINE PHOSPHATE PLUS TENOFOVIR; (P(1) THYMIDINE 3' AZIDO 2',3' DIDEOXYRIBOSIDE 5') P(2) (9 2 (PHOSPHONOMETHOXYPROPYL)ADENINE); (P(1)-THYMIDINE-3'-AZIDO-2',3'-DIDEOXYRIBOSIDE-5')-P(2)-(9-2-(PHOSPHONOMETHOXYPROPYL)ADENINE); ADENINE; ANTI HIV AGENTS; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; DRUG DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG PENETRATION; ERYTHROCYTE KINETICS; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MACROPHAGE ACTIVATION; PHOSPHORYLATION; PRIORITY JOURNAL; STOICHIOMETRY; VIRUS INHIBITION; VIRUS REPLICATION; CELL ADHESION; CHEMISTRY; DRUG EFFECT; DRUG STABILITY; ERYTHROCYTE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MACROPHAGE; METABOLISM; VIROLOGY;

ADENINE; ANTI-HIV AGENTS; CELL ADHESION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ERYTHROCYTES; HIV-1; HUMAN; IN VITRO; MACROPHAGES; SUPPORT, NON-U.S. GOV'T; VIRUS REPLICATION; ZIDOVUDINE;

EID: 0034797940     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020101200302     Document Type: Article

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