Synthesis and targeted delivery of an azidothymidine homodinucleotide conferring protection to macrophages against retroviral infection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 9, 1996, Pages 4403-4408

  Magnani, Mauro ^a   Casabianca, Anna ^a   Fraternale, Alessandra ^a   Brandi, Giorgio ^a   Gessani, Sandra ^b   Williams, Rosamund ^c   Giovine, Marco ^d   Damonte, Gianluca ^d   De Flora, Antonio ^d   Benatti, Umberto ^d  

^a UNIVERSITY OF URBINO   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c Gruppo Lepetit SpA   (Italy)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

di(thymidine 3' azido 2',3' dideoxy D riboside) 5' 5' p1 p2 pyrophosphate (AZTp2AZT); drug targeting; erythrocytes; feline and murine immunodeficiency; human immunodeficiency virus inhibition

Indexed keywords

BIS(THYMIDINE 3' AZIDO 2',3' DIDEOXYRIBOSIDE 5',5' P1,P2 PYROPHOSPATE); UNCLASSIFIED DRUG; ZIDOVUDINE DERIVATIVE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; DRUG TARGETING; ERYTHROCYTE; FELINE IMMUNODEFICIENCY VIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; BASE SEQUENCE; CATS; CELLS, CULTURED; DNA PRIMERS; ERYTHROCYTES; HIV-1; HUMANS; IMMUNODEFICIENCY VIRUS, FELINE; KINETICS; MACROPHAGES; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PHAGOCYTOSIS; POLYMERASE CHAIN REACTION; PRODRUGS; THYMINE NUCLEOTIDES; VIRUS REPLICATION;

EID: 9344245107     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.9.4403     Document Type: Article

References (35)

1. Gartner, S., Markovits, P., Markovits, D. M., Kaplan, M. H., Gallo, R. C. & Popovic, M. (1986) Science 233, 215-219.
2. Ho, D. D., Rota, T. R. & Hirsch, M. S. (1986) J. Clin. Invest. 77, 1712-1715.
3. Koenig, S., Gendelman, H. E., Orenstein, J. M., Dal Canto, M. C., Pezeshjpour, G. H., Yungbluth, M., Janotta, F., Aksamit, A., Martin, M. A. & Fauci, A. S. (1986) Science 233, 1089-1093.
4. Tschachler, E., Groh, V., Popovic, M., Mann, D. L., Konrad, K., Safai, B., Eron, L., diMarzo Veronese, L., Wolff, K. & Stingl, G. (1987) J. Invest. Dermatol. 88, 233-237.
5. Armstrong, J. A. & Horne, R. (1984) Lancet ii, 370-372.
6. Salahuddin, S. Z., Rose, R. M., Groopman, J. E., Markham, P. D. & Gallo, R. C. (1986) Blood 68, 281-284.
7. Mitsuja, H., Yarchoan, R. & Broder, S. (1990) Science 249, 1533-1544.
8. De Clercq, E. (1991) J. AIDS 4, 207-218.
9. Gao, W., Cara, A., Gallo, R. & Lori, F. (1993) Proc. Natl. Acad. Sci. USA 90, 8925-8928.
10. Gao, W., Agbaria, R., Driscoll, J. S. & Mitsuja, H. (1994) J. Biol. Chem. 269, 12633-12638.
11. Perno, C. F., Yarchoan, R., Cooney, D. A., Hartman, N. R., Gartner, S., Popovic, M., Hao, Z., Gerrard, T. L., Wilson, Y. A., Johns, D. G. & Broder, S. (1988) J. Exp. Med. 168, 1111-1125.
12. Richmann, D. D., Kornbluth, R. S. & Carson, D. A. (1987) J. Exp. Med. 166, 1144-1149.
13. Perno, C. F., Yarchoan, R., Cooney, D. A., Hartman, N. R., Webb, D. S. A., Hao, Z., Mitsuya, H., Johns, D. G. & Broder, S. (1989) J. Exp. Med. 169, 933-951.
14. Magnani, M., Rossi, L., Brandi, G., Schiavano, G. F., Montroni, M. & Piedimonte, G. (1992) Proc. Natl. Acad. Sci. USA 89, 6477-6481.
15. Magnani, M., Rossi, L., Fraternale, A., Silvotti, L., Quintavalla, F., Piedimonte, G., Matteucci, D., Baldinotti, F. & Bendinelli, M. (1994) AIDS Res. Hum. Retroviruses 10, 1179-1186.
16. Rossi, L., Brandi, G., Fraternale, A., Schiavano, G. F., Chiarantini, L. & Magnani, M. (1993) J. AIDS 6, 1179-1186.
17. Magnani, M., Casablanca, A., Rossi, L., Fraternale, A., Brandi, G., Silvotti, L. & Piedimonte, G. (1995) Antiviral Chem. Chemother. 6, 312-319.
18. Parker, W. B. & Cheng, Y. C. (1994) J. NIH Res. 6, 57-61.
19. Lewis, W. & Dalakas, M. C. (1995) Nat. Med. 1, 417-422.
20. Mosier, D. E., Yetter, R. A. & Morse, H. C., III (1987) J. Exp. Med. 165, 1737-1742.
21. Piedimonte, G., Montroni, M., Silvestri, G., Silvotti, L., Donatini A., Rossi, L., Borghetti, A. F. & Magnani, M. (1992) Arch. Virol. 130, 463-469.
22. Magnani, M., Giovine, M., Fraternale, A., Damonte, G., Rossi, L, Scarfi, S., Benatti, U. & De Flora, A. (1995) Drug Delivery 2, 57-61.
23. Michelson, A. M. (1964) Biochim. Biophys. Acta 91, 1-13.
24. Magnani, M., Rossi, L., Bianchi, M., Cucchiarini, L. & Stocchi, V. (1989) J. Chromatogr. 491, 215-220.
25. Pauwels, R., Balzarini, J., Baba, M., Snoeck, R., Schols, D., Herdwijn, P., Desmyter, J. & De Clercq, E. (1988) J. Virol. Methods 20, 309-321.
26. Bendinelli, M., Pistello, M., Lombardi, S., Poli, A., Garzelli, C., Matteucci, D., Ceccherini-Nelli, L., Malvoldi, G. & Tozzini, F. (1995) Clin. Microbiol. Rev. 8, 87-112.
27. De Flora, A., Zocchi, E., Guida, L., Polvani, C. & Benatti, U. (1988) Proc. Natl. Acad. Sci. USA 85, 3145-3149.
28. Magnani, M., Bianchi, M., Rossi, L. & Stocchi, V. (1989) Biochem. Biophys. Res. Commun. 164, 446-452.
29. Gasparini, A., Giovine, M., Damonte, G., Tonetti, M., Grandi, T., Mazzei, M., Balbi, A., Silvestro, L., Benatti, U. & De Flora, A. (1994) Biochem. Pharmacol. 48, 1121-1128.
30. Zocchi, E., Guida, L., Franco, L., Guerrini, M., Benatti, U. & De Flora, A. (1993) Biochem. J. 295, 121-130.
31. Jaffè, E. R. & Neuman, G. (1965) Transfusion 5, 412-420.
32. Busso, M., Mian, A. M., Hahn, A. & Resnick, L. (1988) AIDS Res. Hum. Retroviruses 4, 449-455.
33. Puech, F., Gosselin, G., Balzarini, J., Good, S. S., Rideout, J. L., De Clerq, E. & Imbach, J. L. (1990) Antiviral Res. 12, 11-23.
34. Schinazi, R. F., Sommadossi, J. P., Saalmann, V., Cannon, D. L., Xia, M. Y., Hart, G. C., Smith, G. A. & Hahn, E. F. (1990) Antimicrob. Agents Chemother. 34, 1061-1067.
35. Velazquez, S., Alvarez, R., San-felix, A., Jimeno, M. L., De Clerq, E., Balzarini, J. & Camarasa, M. J. (1995) J. Med. Chem. 38, 1641-1649.