Immunotherapy directed against α-fetoprotein results in autoimmune liver disease during liver regeneration in mice

Gastroenterology

Volumn 121, Issue 4, 2001, Pages 931-939

  Geissler, Michael ^a   Mohr, Leonhard ^a   Weth, Robert ^a   Köhler, Gabriele ^a   Grimm, Christian F ^a   Krohne, Tim U ^a   Von Weizsäcker, Fritz ^a   Blum, Hubert E ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; AUTOANTIGEN; DNA VACCINE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOTHERAPY; LIVER DISEASE; LIVER INJURY; LIVER REGENERATION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; T LYMPHOCYTE;

EID: 0034797669     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.28019     Document Type: Article

References (32)

1. Hepatocellular carcinoma
2. Cellular aspects of alpha-fetoprotein reexpression in tumors
3. Hepatocellular carcinoma
4. Mouse α-fetoprotein-specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice
5. Alpha-fetoprotein-specific genetic immunotherapy for hepatocellular carcinoma
6. Alpha-fetoprotein gene regulation: Lessons from transgenic mice
7. Wegener's granulomatosis associated with renal cell carcinoma
8. Vitiligo in patients with melanoma: Normal tissue antigens can be targets for cancer immunotherapy
9. Regression of small-cell lung carcinoma in patients with paraneoplastic neuronal antibodies
10. CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose
11. Immunotherapy with dendritic cells directed against tumor antigens shared with normal host cells results in severe autoimmune disease
12. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines
13. Enhancement of cellular and humoral immune responses to hepatitis C virus (HCV) core protein using DNA based vaccines augmented with cytokine expressing plasmids
14. + T-cell dependent
15. Ongoing T1 or T2 immune responses to the hepatitis B surface antigen (HBsAg) are excluded from the liver of mice in which transgene-encoded HBsAg is expressed
16. The extent of synchronous initiation and termination of DNA synthesis in regenerating mouse liver is dependent on connexin32 expressing gap junctions
17. Intracellular retention of hepatitis B virus surface proteins reduces the immune response augmenting effects of IL-2 after cytokine genetic coimmunizations
18. α-fetoprotein gene sequences mediating Afr2 regulation during liver regeneration
19. Genetic analysis of α-fetoprotein synthesis in mice
20. Strain-dependent differences in DNA synthesis and gene expression in the regenerating livers of C57BL/6J and C3H/HeJ mice
21. + T cell tolerance to peripherally expressed antigens
22. + T cell deletion induced by cross-presentation of self antigens and favors autoimmunity
23. Constitutive class I-restricted exogenous presentation of self antigens in vivo
24. Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels
25. Tumor antigens are constitutively presented in the draining lymph nodes
26. Genetic control of alpha-fetoprotein synthesis in the mouse
27. Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice
28. Activation of low avidity CTL specific for a self epitope results in tumor rejection but not in autoimmunity
29. An evaluation of the potential to use tumor-associated antigens as targets for antitumor T cell therapy using transgenic mice expressing a retroviral tumor antigen in normal lymphoid tissues
30. Mechanisms for virus-induced liver disease: Tumor necrosis factor-mediated pathology independent of natural killer and T cells during murine cytomegalovirus infection
31. Cytokine-induced viral purging: Role in viral pathogenesis
32. Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice