Digoxin toxicity secondary to clarithromycin therapy

Annals of Pharmacotherapy

Volumn 31, Issue 7-8, 1997, Pages 864-866

  Nawarskas, James J ^a   McCarthy, David M ^b   Spinler, Sarah A ^a,b,c  

^a UNIVERSITY OF THE SCIENCES   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c Philadelphia Coll Pharm and Sci   (United States)

Author keywords

Clarithromycin; Digoxin; Toxicity

Indexed keywords

ACETYLSALICYLIC ACID; CAPTOPRIL; CLARITHROMYCIN; DIGOXIN; DIGOXIN ANTIBODY; ERYTHROMYCIN; FUROSEMIDE; GLYCERYL TRINITRATE;

AGED; ARTICLE; CASE REPORT; CLINICAL FEATURE; CONGESTIVE HEART FAILURE; DIARRHEA; DIGITALIS INTOXICATION; DRUG BIOAVAILABILITY; DRUG ELIMINATION; ELECTROCARDIOGRAM; FEMALE; HEART VENTRICLE TACHYCARDIA; HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030744784     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1177/106002809703100711     Document Type: Article

References (21)

1. Friedman HS, Bonventre MV. Erythromycin-induced digoxin toxicity (letter). Chest 1982;82:202.
2. Maxwell DL, Gilmour-White SK, Hall MR. Digoxin toxicity due to interaction of digoxin with erythromycin. BMJ 1989;298:572.
3. Morton MR, Cooper JW. Erythromycin-induced digoxin toxicity. DICP Ann Pharmacother 1989;23:668-70.
4. Nørregaard-Hansen K, Klitgaard NA, Pedersen KE. The significance of the enterohepatic circulation on the metabolism of digoxin in patients with the ability of intestinal conversion of the drug. Acta Med Scand 1986;220:89-92.
5. Lindenbaum J, Rund DG, Butler VP Jr, Tse-Eng D, Saha JR. Inactivation of digoxin by the gut flora: reversal by antibiotic therapy. N Engl J Med 1981;305:789-94.
6. Sutton A, Pilot MA. Digoxin toxicity and erythromycin (letter). BMJ 1989;298:1101.
7. Taylor JW, Gammenthaler SA, Rape JM. Clarithromycin (Biaxin) induced digoxin toxicity (abstract 3111964). Presented at the American Society of Health-System Pharmacists Midyear Clinical Meeting, Miami, FL, December 1994.
8. Midoneck SR, Etingin OR. Clarithromycin-related toxic effects of digoxin (letter). N Engl J Med 1995;333:1505.
9. Ford A, Smith LC, Baltch AL, Smith RP. Clarithromycin-induced digoxin toxicity in a patient with AIDS. Clin Infect Dis 1995;21:1051-2.
10. Marriott HJL. Drug effects: digitalis and quinidine. In: Gardner JN, ed. Practical electrocardiography. 8th ed. Baltimore: Williams & Wilkins, 1988:478-95.
11. Lindenbaum J, Tse-Eng D, Butler VP Jr, Rund DG. Urinary excretion of reduced metabolites of digoxin. Am J Med 1981;71:67-74.
12. Dobkin JF, Saha JR, Butler VP Jr, Neu HC, Lindenbaum J. Digoxin-inactivating bacteria: identification in human gut flora. Science 1983;220: 325-7.
13. Guay DRP, Patterson DR, Seipman N, Craft JC. Overview of the tolerability profile of clarithromycin in preclinical and clinical trials. Drug Saf 1993;8:350-64.
14. Friedman PL. Factors in individual sensitivity to cardiac glycosides and recognition of digitalis intoxication. Primary Cardiol 1988;1:13-7.
15. Johnson BF, Bustrack JA, Urbach DR, Hull JH, Marwaha R. Effect of metoclopramide on digoxin absorption from tablets and capsules. Clin Pharmacol Ther 1984;36:724-30.
16. Kirch W, Janisch HD, Santos SR, Duhrsen U, Dylewicz P, Ohnhaus EE. Effect of cisapride and metoclopramide on digoxin bioavailability. Eur J Drug Metab Pharmacokinet 1986;11:249-50.
17. Manninen V, Melin J, Apajalahti A, Karesoja M. Altered absorption of digoxin in patients given propantheline and metoclopramide. Lancet 1973;1:398-400.
18. von Rosenstiel NA, Adam D. Macrolide antibacterials. Drug interactions of clinical significance. Drug Saf 1995;13:105-22.
19. Reuning RH, Geraets DR, Rocci ML, Vlasses PH. Digoxin. In: Evans WE, Schentag JJ, Jusko WJ, eds. Applied pharmacokinetics. 3rd ed. Vancouver, WA: Applied Therapeutics, Inc., 1992:20-1-20-48.
20. Winter ME. Digoxin. In: Koda-Kimble MA, Young LE, eds. Basic clinical pharmacokinetics. 3rd ed. Vancouver, WA: Applied Therapeutics, Inc., 1994:198-235.
21. Gault MH, Sugden D, Maloney C, Ahmed M, Tweeddale M. Biotransformation and elimination of digoxin with normal and minimal renal function. Clin Pharmacol Ther 1979;25:499-513.