WAY 100635, a 5-HT(1A) receptor antagonist, prevents the impairment of spatial learning caused by blockade of hippocampal NMDA receptors

Neuropharmacology

Volumn 38, Issue 8, 1999, Pages 1165-1173

  Carli, M ^a   Silva, S ^a   Balducci, C ^a   Samanin, R ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

3 ((R) 2 carboxypiperazin 4 yl)propyl 1 phosphonic acid; Hippocampus; NMDA receptor; Rat; Serotonin 5 HT(1A) receptor; Spatial learning; WAY 100635

Indexed keywords

4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SEROTONIN 1A ANTAGONIST;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; INTRACEREBRAL DRUG ADMINISTRATION; LEARNING DISORDER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL DISCRIMINATION; SUBCUTANEOUS DRUG ADMINISTRATION; VISUAL DISCRIMINATION; WORKING MEMORY;

ANIMALS; DISCRIMINATION LEARNING; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; MALE; PIPERAZINES; PYRIDINES; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS;

EID: 0033012438     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00038-6     Document Type: Article

References (26)

1. 1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal administration of scopolamine or 7-chloro-kynurenic acid. Brain Res. 774:1997a;167-174.
2. 1A in the dorsal hippocampus impairs acquisition and performance of a spatial task in a water maze. Brain Res. 595:1992;50-56.
3. 1A receptors in the hippocampus. Behav. Brain Res. 67:1995a;67-74.
4. 1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine. Eur. J. Pharmacol. 283:1995b;133-139.
5. 3 receptor antagonist. Behav. Brain Res. 82:1997b;185-194.
6. 1A receptors. Br. J. Pharmacol. 105:1992;720-726.
7. Chaput Y., Araneda R.C., Andrade R. Pharmacological and functional analysis of a novel serotonin receptor in the rat hippocampus. Eur. J. Pharmacol. 182:1990;441-456.
8. Doze V.A., Cohen G.A., Madison D.V. Synaptic localization of adrenergic dishinibition in the rat hippocampus. Neuron. 6:1991;889-900.
9. Geddes J.W., Chang-Chui H., Cooper S.M., Lott I.T., Cotman C.W. Density and distribution of NMDA receptors in the human hippocampus in Alzheimer's disease. Brain Res. 399:1986;156-161.
10. 1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur. J. Pharmacol. 211:1992;211-219.
11. 1A antagonist, WAY 100635, ameliorates the cognitive impairment induced by fornix transection in the marmoset. Psychopharmacology. 127:1996;245-254.
12. Ladinsky H., Consolo S., Tirelli A.S., Forloni G.L. Evidence for noradrenergic mediation of the oxotremorine-induced increase in acetylcoline content in rat hippocampus. Brain Res. 187:1980;494-498.
13. 1A receptor in hippocampal dentate gyrus. Soc.Neurosci.Abstr. 20(1):1994;731.
14. Morris R.G.M., Garrud P., Rawlins J.N.P., O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature. 297:1982;681-683.
15. Morris R.G.M., Hagan J.J., Rawlins J.N.P. Allocentric spatial learning by hippocampectomised rats: a further test of the 'spatial mapping' and 'working memory' theories of hippocampal function. Q. J. Exp. Psychol. 38B:1986;365-395.
16. Mynlieff M., Dunwiddie T.V. Noradrenergic depression of synaptic responses in hippocampus of rats: evidence for mediation by alpha1-receptors. Neuropharmacology. 27:1988;391-398.
17. 1A receptors compensates loss of hippocampal cholinergic neurotrasmission involved in working memory of rats. Brain Res. 736:1996;180-188.
18. Ohno M., Yamamoto T., Watanabe S. Effects of intrahippocampal injections of N-Methyl-D-Aspartate receptor antagonists and scopolamine on working and reference memory assessed in rats by a three-panel runway task. J. Pharmacol. Exp. Ther. 263:1992;943-950.
19. O'Keefe J., Nadel L. The Hippocampus as a Cognitive Map. 1978;Oxford University Press, Oxford.
20. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. 1982;Academic Press, Sydney.
21. Perry E.K., Tomlinson B.E., Blessed G., Bergmann K., Gibson P.H., Perry R.H. Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br. Med. J. 2:1978;1457-1459.
22. 3H)MK-801 binding in Alzheimer's disease. J.Neurochem. 53:1989;698-704.
23. 1A receptor agonist and a muscarinic acetylcholine receptor antagonist disrupts water maze navigation behavior. Psychopharmacology. 122:1995;137-146.
24. Van Wijngaarden I., Tulp M.Th.M., Soudijn W. The concept of selectivity in 5-HT receptor research. Eur. J. Pharmacol. 188:1990;301-312.
25. Whitehouse P.J., Price D.L., Struble R.G., Clark A.W., Coyle J.T., DeLong M.R. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science. 215:1982;1237-1239.
26. Winer B.J. Statistical Principles in Experimental Design. 2nd:1971;McGraw-Hill, Tokyo.