Activation of cyclin E-dependent kinase activity in colorectal cancer

Digestive Diseases and Sciences

Volumn 46, Issue 10, 2001, Pages 2187-2198

  Cam, William Renyifo ^a   Masaki, Tsutomu ^a,b   Shiratori, Yasushi ^a   Kato, Naoya ^a   Okamoto, Makoto ^a   Yamaji, Yutaka ^a   Igarashi, Kouichi ^a   Sano, Takaaki ^c   Omata, Masao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

^c GUNMA UNIVERSITY   (Japan)

Author keywords

Cdk2; Colorectal adenoma; Colorectal cancer; Cyclin E; Cyclin E kinase

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN E; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; PROTEIN P21; PROTEIN P27;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; FEMALE; GENE AMPLIFICATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; WESTERN BLOTTING;

ADENOMA; AGED; AGED, 80 AND OVER; APOPTOSIS; BLOTTING, WESTERN; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; COLORECTAL NEOPLASMS; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 0034793790     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011962915280     Document Type: Article

References (47)

1. A genetic model for colorectal tumorigenesis
2. Amplification of cyclin genes in colorectal carcinomas
3. Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis
4. Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas
5. Mammalian G1 cyclins
6. 1 phase progression: Cycling on cue
7. 1 in mammalian fibroblast
8. Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
9. Human cyclin E, a new cyclin that interacts with two members of the cdc2 gene family
10. 1 phase of the human cell-cycle
11. 1-S protein kinase
12. 1-phase transition by expression of cyclin D1 and E with an inducible system
13. 1-to-S phase transition
14. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
15. p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
16. Expression and amplification of cyclin genes in human breast cancer
17. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
18. The adenovirus EIA-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33 cdk2
19. Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins
20. The classification of cancer of the rectum
21. 1 cyclins in the functional inactivation of the retinoblastoma protein
22. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
23. Electrophoretic transfer of protein from polyacrylamide gel to nitrocellulose sheets: Procedure and some applications
24. Cdk2 encodes a 33KDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle
25. Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts
26. 1 cyclin-dependent kinases
27. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
28. Analysis of cyclin E and CDK2 in ovarian cancer: Gene amplification and RNA overexpression
29. 1 and E in human colon adenocarcinomas
30. Amplified Cdk2 and cdc2 activities in primary colorectal carcinoma
31. Cyclin E overexpression responsible for growth of human hepatic tumors with p21WAF1/CIP1/SDI1
32. Cyclin E, a potential prognostic marker for breast cancer
33. Prognostic value of cyclin E and p53 expression in gastric carcinoma
34. Overexpression of cyclin E in acute myelogenous leukemia
35. Expression of cell cycle regulated proteins in prostate cancer
36. Less expression of cyclin E in cutaneous squamous cell carcinomas than in benign and premalignant keratinocytic lesions
37. 1 cyclins, cdk2, and cyclin A during the differentiation of HL60 cells induced by TPA
38. 1 cyclins and cyclin-dependent protein kinases
39. Cell cycle-specific induction of Cdk2 expression in B lymphocytes following antigen receptor cross-linking
40. Characterization of the human cyclin-dependent kinase 2 gene. Promoter analysis and gene structure
41. Cyclin E dependent kinase activity in human breast cancer in relation to cyclin E, p27 and p21 expression and retinoblastoma protein phosphorylation
42. Comparative effects of overexpression of p27Kip1 and p21Cip1/Waf1 on growth and differentiation in human colon carcinoma cells
43. p21/WAF1/CIP1 expression in normal mucosa and in adenomas and adenocarcinomas of the colon: Its relationship with differentiation
44. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
45. Cdk2/cdc2 expression in colon carcinogenesis and effects of cdk2/cdc2 inhibitor in colon cancer cells
46. Oncogenic activity of cyclin D1 revealed through cooperation with Ha-ras: Link between cell cycle control and malignant transformation
47. Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer