Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: Death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression

Japanese Journal of Cancer Research

Volumn 92, Issue 9, 2001, Pages 918-925

  Ikeda, Noriko ^a   Miyoshi, Yasuo ^a   Motomura, Kazuyoshi ^b   Inaji, Hideo ^b   Koyama, Hiroki ^b   Noguchi, Shinzaburo ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

Author keywords

Apoptosis; Bcl xL; Caspase 8; Geranylgeraniol; Hepatocellular carcinoma

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; DNA FRAGMENT; GERANYLGERANIOL; MEVALONIC ACID; PROTEIN BAX; PROTEIN BCL X; RECEPTOR PROTEIN; URSODEOXYCHOLIC ACID;

APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HEPATOMA CELL; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL;

APOPTOSIS; BCL-X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; CYSTEINE PROTEINASE INHIBITORS; DITERPENES; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MEVALONIC ACID; NEOPLASM PROTEINS; OLIGOPEPTIDES; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; URSODEOXYCHOLIC ACID; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 0034792075     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2000.tb01035.x     Document Type: Article

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