A novel chromosomal translocation t(3;5)(q12;p15.3) and loss of heterozygosity on chromosome 22 in a multifocal follicular variant of papillary thyroid carcinoma presenting with skin metastases

Clinical Endocrinology

Volumn 55, Issue 4, 2001, Pages 543-548

  Smit, Jan W A ^a   Van Zelderen Bhola, Shama ^a   Merx, Renee ^a   De Leeuw, Wiljo ^a   Wessels, Hans ^a   Vink, Robert ^a   Morreau, Hans ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA; RADIOACTIVE IODINE; THYROGLOBULIN; THYROXINE;

AGED; ARTICLE; BONE METASTASIS; CANCER TEST; CASE REPORT; CHROMOSOME 22; CHROMOSOME ANALYSIS; CHROMOSOME TRANSLOCATION; CLINICAL FEATURE; DIAGNOSTIC ERROR; DISEASE COURSE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLICULAR CARCINOMA; GENE REARRANGEMENT; HETEROZYGOSITY LOSS; HETEROZYGOTE DETECTION; HIDRADENOMA; HUMAN; HUMAN TISSUE; LUNG METASTASIS; MULTIPLE CANCER; PRIORITY JOURNAL; PROTO ONCOGENE; RADIOISOTOPE THERAPY; SCALP TUMOR; SKIN METASTASIS; THYROID PAPILLARY CARCINOMA; TREATMENT OUTCOME; TUMOR LOCALIZATION; WHOLE BODY SCINTISCANNING;

AGED; BONE NEOPLASMS; CARCINOMA, PAPILLARY, FOLLICULAR; CHROMOSOMES, HUMAN, PAIR 22; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 5; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; IODINE RADIOISOTOPES; KARYOTYPING; LOSS OF HETEROZYGOSITY; LUNG NEOPLASMS; SKIN NEOPLASMS; THYROID NEOPLASMS; TRANSLOCATION, GENETIC;

EID: 0034790834     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2001.01311.x     Document Type: Article

References (18)

1. Cytogenetic studies on 19 papillary thyroid carcinomas
2. Cytogenetic changes in benign thyroid gland hyperplasias and adenomas correlated with histology
3. Thyroid carcinoma metastatic to the skin: A cutaneous manifestation of a widely disseminated malignancy
4. Distant metastases in papillary thyroid carcinoma: 100 Cases observed at one institution during 5 decades
5. Molecular and biochemical analysis of RET/PTC4, a novel oncogenic rearrangement between RET and ELE1 genes, in a post-Chernobyl papillary thyroid cancer
6. An international system for human cytogenetic nomenclature
7. Frequent occurrence of cytogenetic abnormalities in sporadic nonmedullary thyroid carcinoma
8. Molecular analysis of new subtypes of ELE/RET rearrangements, their reciprocal transcripts and breakpoints in papillary thyroid carcinomas of children after Chernobyl
9. PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma
10. Fusion of a novel gene, ELKS, to RET due to translocation t (10;12) (q11;p13) in a papillary thyroid carcinoma
11. Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children
12. Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells
13. Tumors of thyroid gland
14. Recent advances in cytometry, cytogenetics and molecular genetics of thyroid tumours and tumour-like lesions
15. High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: A strong correlation between RET/PTC3 and the solid-follicular variant
16. Loss of heterozygosity of the long arm of chromosome 7 in follicular and anaplastic thyroid cancer, but not in papillary thyroid cancer
17. Allelotype of follicular thyroid carcinomas reveals genetic instability consistent with frequent nondisjunctional chromosomal loss
18. Studies of allelic loss in thyroid tumors reveal major differences in chromosomal instability between papillary and follicular carcinomas