Elucidation of conditions allowing conversion of penicillin G and other penicillins to deacetoxycephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 20, 1998, Pages 11544-11548

  Cho, Hiroshi ^a,e   Adrio, José L ^a,f   Luengo, José M ^c   Wolfe, Saul ^d   Ocran, Simeon ^b   Hintermann, Gilberto ^b   Piret, Jacqueline M ^b   Demain, Arnold L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c UNIVERSITY OF LEÓN   (Spain)

^d SIMON FRASER UNIVERSITY   (Canada)

^e MITSUBISHI CHEMICAL CORPORATION   (Japan)

^f Avenida de Antibioóticos 59 61   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CEPHALOSPORIN DERIVATIVE; DEACETOXYCEPHALOSPORIN C; PENICILLIN G;

ARTICLE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES CLAVULIGERUS;

ADENOSINE TRIPHOSPHATE; ASCORBIC ACID; CEPHALOSPORINS; COLONY COUNT, MICROBIAL; DITHIOTHREITOL; FERROUS COMPOUNDS; INTERPHASE; INTRAMOLECULAR TRANSFERASES; KETOGLUTARIC ACIDS; KINETICS; MAGNESIUM SULFATE; PENICILLIN G; PENICILLIN-BINDING PROTEINS; PENICILLINS; POTASSIUM CHLORIDE; STREPTOMYCES;

EID: 0032578517     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.20.11544     Document Type: Article

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