Hyperlactataemia and hepatic steatosis: Mitochondrial toxicity of nucleoside reverse transcriptase inhibitors

Sexually Transmitted Infections

Volumn 77, Issue 5, 2001, Pages 381-384

  Pao, D ^a   Watson, C ^a   Peters, B ^a   Lucas, S B ^b   Miller, R F ^c  

^a Academic Department of Genitourinary Medicine   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; AMPHOTERICIN; CIPROFLOXACIN; CLARITHROMYCIN; CLINDAMYCIN; DEXAMETHASONE; FOLINIC ACID; FUSIDATE SODIUM; ISOTRETINOIN; LACTIC ACID; PHENYTOIN; PYRIMETHAMINE SULFADIAZINE; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; STAVUDINE;

ADULT; CANDIDIASIS; CASE REPORT; CLINICAL FEATURE; CONFERENCE PAPER; DIAGNOSTIC PROCEDURE; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG WITHDRAWAL; FATTY LIVER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; HYPERLACTATEMIA; LIVER BIOPSY; LIVER MITOCHONDRION; LIVER TOXICITY; LYMPHADENITIS; MALE; PRIORITY JOURNAL; TOXOPLASMOSIS; TREATMENT OUTCOME; UNCONSCIOUSNESS;

ACIDOSIS, LACTIC; ADULT; ANTI-HIV AGENTS; DIAGNOSIS, DIFFERENTIAL; FATTY LIVER; HIV INFECTIONS; HUMANS; MALE; MITOCHONDRIA, LIVER; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 0034788222     PISSN: 13684973     EISSN: None     Source Type: Journal    
DOI: 10.1136/sti.77.5.381     Document Type: Conference Paper

References (12)

1. Magnetic resonance imaging, thallium-201 SPET scanning and laboratory analyses for discrimination of central nervous system lymphoma and toxoplasmosis in AIDS
2. Adverse effects and drug interactions of medications commonly used in the treatment of adult HIV positive patients - 2
3. Fatal haemorrhage following liver biopsy in patients with HIV infection
4. Mitochondrial myopathy caused by long-term zidovudine toxicity
5. Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy
6. Mitochondrial myopathy associated with chronic zidovudine therapy in AIDS
7. Adverse effects of reverse transcriptase inhibitors: Mitochondrial toxicity as common pathway
8. Lactic acidosis complicating the acquired immunodeficiency syndrome
9. Hepatomegaly and steatosis in HIV-infected patients receiving nucleoside analog antiretroviral therapy
10. Hyperlactatemia and hepatic abnormalities in 10 human immunodeficiency virus-infected patients receiving nucleoside analogue combination regimens
11. Editorial response: Hyperlactataemia and hepatic steatosis as features of mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors
12. Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: A looming obstacle for long-term antiretroviral therapy?