Hyperlactatemia and hepatic steatosis as features of mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors

Clinical Infectious Diseases

Volumn 31, Issue 1, 2000, Pages 167-169

  Brinkman, K ^a  

^a Onze Lieve Vrouwe Gasthuis ^*  (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOSIDE ANALOG; STAVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; NUCLEOSIDE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL ACTIVITY; CLINICAL FEATURE; DRUG EFFECT; EDITORIAL; ENZYME INHIBITION; FATTY LIVER; GLYCOLYSIS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERLACTATEMIA; MITOCHONDRIAL MEMBRANE; OUTCOMES RESEARCH; PRIORITY JOURNAL; CHEMICALLY INDUCED DISORDER; HUMAN; LACTIC ACIDOSIS; LIVER DISEASE; LIVER MITOCHONDRION; NOTE;

ACIDOSIS, LACTIC; ANTI-HIV AGENTS; HIV INFECTIONS; HUMANS; LIVER DISEASES; MITOCHONDRIA, LIVER; NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 0034456943     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/313921     Document Type: Editorial

References (13)

1. Mitochondrial toxicity of antiviral drugs
2. Adverse effects of reverse transcriptase inhibitors: Mitochondrial toxicity as common pathway
3. Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
4. Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome: Report of 2 patients and review of the literature
5. Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: Lactic acidosis, risk factors and therapeutic options
6. Hepatomegaly and steatosis in HIV-in fected patients receiving nucleoside analog antiretroviral therapy
7. Clinical features and risk factors of lactic acidosis following long-term anti-retroviral therapy: 4 Fatal cases
8. Emerging complication of antiretroviral therapy: Symptomatic hyperlactatemia
9. Hyperlactatemia and hepatic abnormalities in 10 HIV-infected patients receiving nucleoside combination regimens
10. Lactic acidosis
11. The occurrence of hyperlactatemia in HIV-infected patients on NRTI treatment
12. Microvesicular steatosis and steatohepatitis: Role of mitochondrial dysfunction and lipid peroxidation
13. Safety of antiprotease therapy after 2 episodes of lactic acidosis in an HIV-infected patient