Lactate stimulation of gonococcal metabolism in media containing glucose: Mechanism, impact on pathogenicity, and wider implications for other pathogens

Infection and Immunity

Volumn 69, Issue 11, 2001, Pages 6565-6572

  Smith, H ^a   Yates, E A ^a   Cole, J A ^a   Parsons, N J ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID;

BACTERIAL GROWTH; BACTERIAL METABOLISM; CULTURE MEDIUM; ENERGY METABOLISM; GLUCOSE METABOLISM; HAEMOPHILUS INFLUENZAE; INFECTION; ISOTOPE LABELING; NEISSERIA GONORRHOEAE; NEISSERIA MENINGITIDIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOGENICITY; PRIORITY JOURNAL; SHORT SURVEY;

CULTURE MEDIA; GLUCOSE; HUMANS; LACTIC ACID; NEISSERIA GONORRHOEAE;

EID: 0034783358     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.11.6565-6572.2001     Document Type: Short Survey

References (68)

1. Inhibition of chemotaxis by organic acids from anaerobes may prevent a purulent response in bacterial vaginosis
2. Phenotypic and genetic variation in the susceptibility of Haemophilus influenzae type b to antibodies to somatic antigens
3. Studies on biological oxidations. II. The oxidation of lactic acid by α-hydroxyoxidase and its mechanism
4. Studies on biological oxidations. I. Oxidations produced by gonococci
5. Neisserial porins inhibit human neutrophil actin polymerization, degranulatation, opsonin receptor expression, and phagocytosis but prime the neutrophils to increase their oxidative burst
6. Effects of human serum on the growth and metabolism of Neisseria gonorrhoeae: An alternative view of serum
7. Phagocyte-derived lactate stimulates oxygen consumption by Neisseria gonorrhoeae
8. Nutritional profiles of Neisseria gonorrhoeae, Neisseria meningitidis and Neisseria lactamica in chemically defined media and the use of growth requirements for gonococcal typing
9. Chaperonins in health and disease
10. A bacterial respiratory burst: Stimulation of the metabolism of Neisseria gonorrhoeae by human serum
11. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
12. Oxidation of D-lactate and L-lactate by Neisseria meningitidis: Purification and cloning of meningococcal D-lactate dehydrogenase
13. Neisseria gonorrhoeae possesses two nicotinamide adenine dinucleotide-dependent lactate dehydrogenases
14. Mutants of Escherichia coli K-12 which synthesize the pyruvated dehydrogenase complex constitutively
15. Whole-genome random sequencing and assembly of Haemophilus influenzae pd
16. Genomic sequence of a lyme disease spirochaete Borrelia burgdorferi
17. Oxidant stress in Neisseria gonorrhoeae: Adaptation and effects on L-(+)-lactate dehydrogenase activity
18. Uptake of metabolites by gonococci grown with lactate in a medium containing glucose; evidence for a surface location of the sialyltransferase
19. Lactate causes changes in gonococci including increased lipopolysaccharide synthesis during short-term incubation in media containing glucose
20. Functional characterization of a sialyltransferase deficient mutant of Neisseria gonorrhoeae
21. Phenotypically determined resistance of Neisseria gonorrhoeae in normal human serum; environmental factors in subcutaneous chambers in guinea pigs
22. A mutation causing constitutive synthesis of the pyruvate dehydrogenase complex in Escherichia coli is located within the pdhR gene
23. DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
24. Radiorespirometric studies in genus Neisseria. 3. The catabolism of pyruvate and acetate
25. Activities of some enzymes concerning pyruvate metabolism in Neisseria
26. Variation and evolution of the citric acid cycle: A genomic perspective
27. Serum factor-dependent resistance of Haemophilus influenzae type b to antibody to lipopolysaccharide
28. Experimental gonococcal genital tract infection and opacity protein expression in estradiol-treated mice
29. Intermediate reactions of the tricarboxylic acid cycle in meningococci
30. Host metabolites that phenotypically increase the resistance of Haemophilus influenzae Type b to clearance mechanisms
31. Multiple mechanisms in serum factor-induced resistance of Haemophilus influenzae type b antibody
32. Source of low-molecular-weight host factors that phenotypically increase the resistance of Haemophilus influenzae type b to bacteriolysis: Nonidentity with a factor active in gonococci
33. The antigen specificity of a serum factor-induced phenotypic shift in Haemophilus influenzae type b, strain Eag
34. On the location of a mutation causing constitutive synthesis of the pyruvate dehydrogenase complex of Escherichia coli K12
35. Symposium on initiation of bacterial growth III. Physiological aspects of growth initiation
36. Mechanism of active transport in isolated membrane vesicles. VIII. The transport of amino acids by membranes prepared from Escherichia coli
37. Factors affecting autolysis of Neisseria gonorrhoeae
38. Effect of pH on the growth and glucose metabolism of Neisseria gonorrhoeae
39. Gonococcal lipooligosaccharide: An adhesin for bacterial dissemination?
40. Identification and molecular analysis of a 63-kilodalton stress protein from Neisseria gonorrhoeae
41. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences
42. Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491
43. Lactic acid is the factor in blood cell extracts which enhances the ability of CMP-NANA to sialylate gonococcal lipopolysaccharide and induce serum resistance
44. r material released from blood cell extracts but not by some UDP-sugars
45. Lactate enhancement of sialylation of gonococcal lipopolysaccharide and induction of serum resistance by CMP-NANA is not due to direct activation of the sialyltransferase: Metabolic events are involved
46. Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
47. Organic constituents of vaginal secretions
48. Lipopolysaccharide and bacterial virulence
49. The membrane phospholipids of Neisseria meningitidis and Neisseria gonorrhoeae as characterized by fast atom bombardment mass spectrometry
50. Roles of glycoproteins and oligosaccharides found in human vaginal fluid in bacterial adherence
51. Regulation of the lipopolysaccharide-specific sialyltransferase activity of gonococci by growth state of the bacteria, but not by carbon source, catabolite repression or oxygen supply
52. Bacterial endotoxin: Molecular relationships of structure to activity and function
53. The effect of serum-factor induced resistance to somatic antibodies on the virulence of Haemophilus influenzae type b
54. The paradox of Haemophilus influenzae type b bacteremia in the presence of serum bactericidal activity
55. Mechanisms of active transport in isolated bacterial membrane vesicles. Further studies on amino acid transport in Staphylococcus aureus membrane vesicles
56. The revival of interest in mechanisms of bacterial pathogenicity
57. Host factors that influence the behaviour of bacterial pathogens in vivo
58. Sialylation of neisserial lipopolysaccharide: A major influence on pathogenicity
59. Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunist pathogen
60. Functional genomics of Neisseria meningitidis pathogenesis
61. Complete genome sequence of Neisseria meningitidis serogroup B strain MC58
62. Glucose and intermediary metabolism in the lung
63. The complete genome sequence of the gastric pathogen Helicobacter pylori
64. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal opa proteins: Intracellular gonococci bind pyruvate kinase via their opa proteins and require host pyruvate for growth
65. Physiology and metabolism of pathogenic Neisseria: Partial characterization of the respiratory chain of Neisseria gonorrhoeae
66. In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased; implications regarding lactate stimulation of metabolism