CRH-deficient mice have a normal anorectic response to chronic stress

Regulatory Peptides

Volumn 84, Issue 1-3, 1999, Pages 69-74

  Weninger, Stacie C ^a,b   Muglia, Louis J ^b   Jacobson, Lauren ^b   Majzoub, Joseph A ^b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Anorexia; Appetite; Gene targeting; Hypophagia; Knockout; Urocortin

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; SAUVAGINE; UROCORTIN; UROTENSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN DEFICIENCY; FEMALE; FOOD INTAKE; GENE TARGETING; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRESS;

ANIMALS; ANOREXIA; CORTICOTROPIN-RELEASING HORMONE; GENOTYPE; MALE; MICE; MICE, KNOCKOUT; STRESS;

EID: 0032847702     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(99)00070-1     Document Type: Article

References (37)

1. Ondrey F.G., Hom D.B. Effects of nutrition on wound healing. Otolaryngol. Head Neck Surg. 110:1994;557-559.
2. Dewys W.D., Begg C., Lavin P.T., Band P.R., Bennett J.M., Bertino J.R., Cohen M.H., Douglass H.O., Engstrom P.F., Esdinli E.Z., Horton J., Johnson G.J., Moertel C.G., Oken M.M., Perlia C., Rosenbaum C., Silverstein M.N., Skeel R.T., Sponzo R.W., Tormey D.C. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Am J Med. 69:1980;491-497.
3. Dallman M.F., Strack A.M., Akana S.F., Bradbury M.J., Hanson E.S., Scribner K.A., Smith M. Feast and famine: critical role of glucocorticoids with insulin in daily energy flow. Front. Neuroendocrinol. 14:1993;303-347.
4. Muglia L., Jacobson L., Dikkes P., Majzoub J.A. Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 373:1995;427-432.
5. Jacobson L. Glucocorticoid replacement, but not corticotropin-releasing hormone deficiency, prevents adrenalectomy-induced anorexia in mice. Endocrinology. 140:1999;310-317.
6. Vale W., Spiess J., Rivier C., Rivier J. Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science. 213:1981;1394-1397.
7. Britton D.R., Koob G.F., Rivier J., Vale W. Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. Life Sci. 31:1982;363-367.
8. Morley J.E., Levine A.S. Corticotrophin releasing factor, grooming and ingestive behavior. Life Sci. 31:1982;1459-1464.
9. Glowa J.R., Gold P.W. Corticotropin releasing hormone produces profound anorexigenic effects in the rhesus monkey. Neuropeptides. 18:1991;55-61.
10. Krahn D.D., Gosnell B.A., Grace M., Levine A.S. CRF antagonist partially reverses CRF- and stress-induced effects on feeding. Brain Res. Bull. 17:1986;285-289.
11. Sutton R., Koob G., Le Moal M., Rivier J., Vale W. Corticotropin releasing factor produces behavioural activation in rats. Nature. 297:1982;331-333.
12. Dunn A., Berridge C. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Rev. 15:1990;71-100.
13. Gosnell B.A., Morley J.E., Levine A.S. A comparison of the effects of corticotropin releasing factor and sauvagine on food intake. Pharmacol. Biochem. Behav. 19:1983;771-775.
14. Negri L., Noviello L., Noviello V. Effects of sauvagine, urotensin I and CRF on food intake in rats. Peptides. 6:(Suppl 3):1985;53-57.
15. Vaughan J., Donaldson C., Bittencort J., Perrin M., Lewis K., Sutton S., Chan R., Turnbull A., Lovejoy D., Rivier C., Rivier J., Sawchenko P., Vale W. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature. 378:1995;287-292.
16. Spina M., Merlo-Pich E., Chan R.K., Basso A.M., Rivier J., Vale W., Koob G.F. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science. 273:1996;1561-1564.
17. Muglia L.J., Jenkins N.A., Gilbert D.J., Copeland N.G., Majzoub J.A. Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells. J Clin Invest. 93:1994;2066-2072.
18. Jeong K.H., Jacobson L., Widmaier E.P., Majzoub J. Normal suppression of the reproductive axis following stress in corticotropin-releasing hormone-deficient mice. Endocrinology. 140:1999;1702-1708.
19. Fattori E., Cappelletti M., Costa P., Sellitto C., Cantoni L., Carelli M., Faggioni R., Fantuzzi G., Ghezzi P., Poli V. Defective inflammatory response in interleukin 6-deficient mice. J. Exp. Med. 180:1994;1243-1250.
20. Hogan B, Beddington R, Constantini F, Lacy E. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory Press, 1994.
21. Udelsman R., Chrousos G.P. Hormonal responses to surgical stress. Adv. Exp. Med. Biol. 245:1988;265-272.
22. Weninger S.C., Dunn A., Muglia L., Dikkes P., Miczek K., Swiergiel A., Berridge C., Majzoub J. Stress-Induced Behaviors Require the CRH Receptor. But Not CRH. Proc Natl Acad Sci USA. 96:1999;8283-8.
23. Johnson R.W. Immune and endocrine regulation of food intake in sick animals. Domest. Anim. Endocrinol. 15:1998;309-319.
24. Kozak W., Poli V., Soszynski D., Conn C.A., Leon L.R., Kluger M.J. Sickness behavior in mice deficient in interleukin-6 during turpentine abscess and influenza pneumonitis. Am. J. Physiol. 272:1997;R621-R630.
25. Turnbull A.V., Smith G.W., Lee S., Vale W.W., Lee K.F., Rivier C. CRF type I receptor-deficient mice exhibit a pronounced pituitary-adrenal response to local inflammation. Endocrinology. 140:1999;1013-1017.
26. Muglia L.J., Jacobson L., Weninger S.C., Luedke C.E., Bae D.S., Jeong K.H., Majzoub J.A. Impaired diurnal adrenal rhythmicity restored by constant infusion of corticotropin-releasing hormone in corticotropin-releasing hormone-deficient mice. J Clin Invest. 99:1997;2923-2929.
27. Kalra S.P., Dube M.G., Pu S., Xu B., Horvath T.L., Kalra P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr. Rev. 20:1999;68-100.
28. Smagin G.N., Howell L.A., Ryan D.H., De Souza E.B., Harris R.B. The role of CRF2 receptors in corticotropin-releasing factor- and urocortin-induced anorexia. Neuroreport. 9:1998;1601-1606.
29. Bradbury M, McBurnie M, Denton D, Lee K-F, Vale W. Divergent effects of CRF receptors on food intake and weight gain: acute vs. chronic urocortin administration in WT and CRFR1 -/- mice. 81st Annual Meeting: The Endocrine Society, 1999.
30. Coste S, Botelho J, Hill J, Kesterson, R, Low, M, Stenzel, P, Stenzel-Poore, M. Corticotropin-releasing hormone receptor-2 deficient mice have impaired feeding responses to urocortin despite normal HPA responses to stress. 81st Annual Meeting: The Endocrine Society, 1999.
31. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J Clin Invest. 98:1996;1101-1106.
32. Heinrichs S.C., Menzaghi F., Pich E.M., Hauger R.L., Koob G.F. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain Res. 611:1993;18-24.
33. Chavez M., Seeley R.J., Havel P.J., Friedman M.I., Matson C.A., Woods S.C., Schwartz M.W. Effect of a high-fat diet on food intake and hypothalamic neuropeptide gene expression in streptozotocin diabetes. J Clin Invest. 102:1998;340-346.
34. Hollopeter G., Erickson J.C., Seeley R.J., Marsh D.J., Palmiter R.D. Response of neuropeptide Y-deficient mice to feeding effectors. Regulatory Peptides. 75-76:1998;383-389.
35. Friedman J.M., Halaas J.L. Leptin and the regulation of body weight in mammals. Nature. 395:1998;763-770.
36. Schwartz M.W., Dallman M.F., Woods S.C. Hypothalamic response to starvation: implications for the study of wasting disorders. Am. J. Physiol. 269:1995;R949-R957.
37. Olson B.R., Drutarosky M.D., Stricker E.M., Verbalis J.G. Brain oxytocin receptors mediate corticotropin-releasing hormone-induced anorexia. Am. J. Physiol. 260:1991;R448-R452.