The analysis of costimulatory receptor signaling cascades in normal T lymphocytes using in vitro gene transfer and reporter gene analysis

Nature Medicine

Volumn 7, Issue 10, 2001, Pages 1155-1158

  Bell, Michael P ^a   Huntoon, Catherine J ^a   Graham, Daniel ^a   McKean, David J ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN BCL 2;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL POPULATION; CELL VIABILITY; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE TRANSFER; GENETIC ANALYSIS; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; IMMUNOTHERAPY; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TECHNIQUE;

ANIMALS; ANTIGENS, CD28; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HUMANS; JURKAT CELLS; LUMINESCENT PROTEINS; MAP KINASE KINASE 1; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSFECTION;

ANIMALIA; MURINAE;

EID: 0034780788     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1001-1155     Document Type: Article

References (11)

1. CD28/B7 system of T cell costimulation
2. Consistent transient transfection of DNA into non-transformed human and murine T-lymphocytes
3. Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells: Convergence of co-stimulatory signals and differences from transformed T cells
4. Transient transfection of primary T helper cells by particle-mediated gene transfer
5. In vivo protein transduction: Delivery of a biologically active protein into the mouse
6. Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease
7. Transformation of mammalian cells by constitutively active MAP kinase kinase
8. ras distinguishes positive and negative selection in thymocytes
9. Maturation vs. Death of developing DP thymocytes reflects competing effects on Bcl-2 expression and can be regulated by the intensity of CD28 costimulation
10. Mechanisms responsible for T cell antigen receptor and CD28- or IL-1 receptor-initiated regulation of IL-2 gene expression by NF-KB
11. Surface molecules that drive T cell development in vitro in the absence of thymic epithelium and in the absence of lineage-specific signals