Heterogeneity in the Polyclonal T Cell Response to Birch Pollen Allergens

International Archives of Allergy and Immunology

Volumn 114, Issue 3, 1997, Pages 272-277

  Dormann, D ^a   Montermann, E ^a   Klimek, L ^a   Weber, B ^b   Ebner, C ^c   Valenta, R ^c   Kraft, D ^c   Reske Kunz, Angelika B ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b ALLERGOPHARMA JOACHIM GANZER KG   (Germany)

^c Institut für Allgemeine und Experimentelle   (Austria)

Author keywords

Allergy type I; Bet v 1; Bet v 2; Immunodominant peptides; T cell antigenicity

Indexed keywords

POLLEN ANTIGEN; POLLEN EXTRACT;

ARTICLE; CLINICAL ARTICLE; HUMAN; LYMPHOCYTE PROLIFERATION; POLLEN ALLERGY; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0030768814     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000237679     Document Type: Article

References (28)

1. Miyamoto T: Increased prevalence of pollen allergy in Japan; in Godard P. Bousquet J, Michel FB (eds): Advances in Allergology and Clinical Immunology. Camforth, Parthenon Publishing Group, 1992, pp 343-347.
2. Ipsen H, Bowadt H, Janniche H, Nuchel Petersen B, Munch EP, Wihl JA, Lowenstein H: Immunochemical characterization of reference alder (Alnus glutinosa) and hazel (Corylus avellana) pollen extracts and the partial immunochemical identity between the major allergens of alder, birch and hazel pollens. Allergy 1985;40:510-518.
3. Jarolim E, Rumpold H, Endler AT, Ebner H, Breitenbach M, Scheiner O, Kraft D: IgE and IgG antibodies of patients with allergy to birch pollen as tools to define the allergen profile of Belula verrucosa. Allergy 1989;44:385-395.
4. Ipsen H, Lowenstein H: Isolation and immunochemical characterization of the major allergen of birch pollen (Belula verrucosa). J Allergy Clin Immunol 1983;72:150-159.
5. Rohac M, Birkner T, Reimitzer I, Boltle B, Steiner R, Breitenbach M, Kraft D, Scheiner O, Gabl F, Rumpold H: The immunological relationship of epitopes on major tree pollen allergens. Mol Immunol 1991;28:897-906.
6. Ferreira FD, Hoffmann Sommergrubcr K, Brei-teneder H, Pettenburger K, Ebner C, Sommcr-grubcr W, Steiner R, Bohlc B, Spcrr WR, Valent P, Kungl AJ, Breitenbach M, Kraft D, Scheiner O: Purification and characterization of recombinant Bel v 1, the major birch pollen allergen. Immunological equivalence to natural Bel v 1. J Biol Client 1993;268:19574-19580.
7. Breiteneder H, Pettenburger K, Bito A, Valcnta R, Kraft D, Rumpold H, Scheiner O, Breitenbach M: The gene coding for the major birch pollen allergen Bel v I is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:1935.
8. Swoboda I, Jilek A, Ferreira F, Engel E, Hoffmann Sommergrubcr K, Scheiner O, Kraft D, Breiteneder H. Pittenauer E, Schmid E, Vicente O, Heberle-Bors E, Ahorn H, Breitenbach M: Isoforms of Bet v 1, the major birch pollen allergen, analyzed by liquid chromatography, mass spectrometry, and cDNA cloning. J Biol Chem 1995;270:2607-2613.
9. Jarolim E, Rumpold H, Endler AT, Schlerka G, Ebner II, Scheiner O, Kraft D: Specificities of IgE and IgG antibodies in patients with birch pollen allergy. Int Arch Allergy Appl Immunol 1989;88:180-182.
10. Valcnta R, Duchenc M, Pettenburger K, Sillaber C, Valent P, Bettelheim P, Breitenbach M, Rumpold H, Kraft D, Scheiner O: Identification of proftlin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 1991: 253:557-560.
11. Valenta R, Duchene M, Ebner C, Valcnl P, Sil-labcr C, Dcviller P, Ferreira F, Tejkl M, Edel-mann H, Kraft D, Schcincr O: ProFtlins constitute a novel family of functional plant pan-allergens. J Exp Med 1992;175:377-385.
12. 2'. EMBO J 1994; 13:3481-3486.
13. Ebner C, Schenk S, Szepfalusi Z, Hoffmann K, Ferreira F, Willheim M, Scheiner O, Kraft D: Multiple T cell specificities for Bel v I, the major birch pollen allergen, within single individuals. Studies using specific T cell clones and overlapping peptides. Eur J Immunol 1993:23: 1523-1527.
14. Ebner C, Szepfalusi Z, Ferreira F, Jilek A, Valenta R, Parronchi P, Maggi E, Rontagnani S, Schcincr O, Kraft D: Identification of multiple T cell epitopes on Bel v I, the major birch pollen allergen, using specific T cell clones and overlapping peptides. J Immunol 1993; 150:1047-1054.
15. Ebner C, Schenk S, Najafian N, Siemann U, Steiner R, Fischer GW, Hoffmann K, Szepfalusi Z, Schcincr O, Kraft D: Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients. J Immunol 1995;154:1932-1940.
16. Ferreira F, Hirtenlehner K, Jilek A, Godnik Cvar J, Breiteneder H, Grimm R, Hoffmann Som-mergruber K, Scheiner O, Kraft D, Breitenbach M, Rheinberger HJ, Ebner C: Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: Potential use of hypoallergenic isoforms for immunotherapy. J Exp Med 1996; 183:599-609.
17. Simons FER, Imada M, Li Y, Watson WTA, Hay Glass KT: Fel d 1 peptides: Effect on skin tests and cytokine synthesis in cat-allergic human subjects. Int Immunol 1996;8:1937-1945.
18. Muller UR, Akdis CA, Fricker M, Blaser K: Im-muntherapie mit T-Zellpeptiden der Bienengift-Phospholipase A2. Allergy J, in press.
19. Brincr TJ, Kuo MC, Keating KM, Rogers BL, Greenstein JL: Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Feld I. Proc Natl Acad Sci USA 1993:90: 7608-7612.
20. Schappi GF, Monn C, Wuthrich B, Wanner HU: Direct determination of allergens in ambient aerosols: Methodological aspects. Int Arch Allergy Immunol 1996;110:364-370.
21. Parronchi P, Macchia D, Piccinni MP, Biswas P, Simonelli C, Maggi E, Ricci M, Ansari AA, Ro-magnani S: Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci USA 1991;88: 4538-4542.
22. Valenta R, Duchene M, Vrtala S, Birkner T, Ebner C, Hirschwehr R, Breitenbach M, Rum-pold H, Scheiner O, Kraft D: Recombinant allergens for immunoblot diagnosis of tree-pollen allergy. J Allergy Clin Immunol 1991;88:889-894.
23. Rontagnani S: Regulation of the development of type 2 T-helper cells in allergy. Curr Opin Immunol 1994;6:838-846.
24. Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT: Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J Exp Med 1993; 178: 2123-2130.
25. Varney VA, Hamid QA, Gaga M, Ying S, Jacobson M, Frew AJ, Kay AB, Durham SR: Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phasc cutaneous responses. J Clin Invest 1993;92:644-651.
26. Jutel M, Pichler WJ, Skrbic D, Urwyler A, Da-hinden C, Muller UR: Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. J Immunol 1995;154:4187-4194.
27. Reskc Kunz AB, Rude E: Analysis of the (H-2b X H-2k)Fl-restricted response to insulin. Ab alpha Ak beta hybrid la molecules restrict the response towards the glutamic acid A4 epitope. Scand J Immunol 1984;20:97-104.
28. Gammon G, Shastri N, Cogswell J, Wilbur S, Sadegh Nasseri S, Krzych U, Miller A, Sercarz E: The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site. Immunol Rev 1987;98:53-73.