Hepatitis B viral polymerase fusion proteins are biologically active and can interact with the hepatitis C virus core protein in vivo

Journal of Biomedical Science

Volumn 8, Issue 6, 2001, Pages 492-503

  Chen, Kun Lin ^a   Chen, Chun Ming ^a   Shih, Chwen Ming ^a   Huang, Huey Lan ^a   Lee, Yan Hwa Wu ^a   Chang, Chungming ^a,b   Lo, Szecheng J ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Endogenous polymerase activity; Evolutionary distance; Hepatitis C virus core protein; Immunofluorescence microscopy; Pol localization; Reverse transcription

Indexed keywords

CORE PROTEIN; FAT DROPLET; HEPATITIS B ANTIBODY; HEPATITIS C ANTIBODY; RIBONUCLEASE H; VIRUS FUSION PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; ASSAY; CELL LINE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; GENETIC TRANSFECTION; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; PLASMID; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRION;

HEPATITIS B VIRUS; HEPATITIS C VIRUS;

EID: 0034766897     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1007/BF02256612     Document Type: Article

References (45)

1. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
2. Expression of the P-protein of the human hepatitis B virus in a vaccinia virus system and detection of the nucleocapsid-associated P-gene product by radiolabelling at newly introduced phosphorylation sites
3. Hepatocellular carcinoma and hepatitis B virus
4. Hepatitis B virus nucleocapsid assembly: Primary structure requirements in the core protein
5. Encapsidation of truncated human hepatitis B virus genomes through trans-complementation of the core protein and polymerase
6. The molecular biology of the hepatitis B viruses
7. A new technique for the assay of infectivity of human adenovirus 5 DNA
8. Mimicry between the hepatitis B virus DNA polymerase and the antigen targets of nuclear and smooth muscle antibodies in chronic hepatitis B virus infection
9. Liver disease activity and hepatitis B virus replication in chronic delta antigen-positive hepatitis B virus carriers
10. Comparative biology and pathogenesis of AIDS and hepatitis B viruses: Related but different
11. cis-acting sequence required for encapsidation of duck hepatitis B virus pregenomic RNA
12. RNA signals for translation frameshift: Influence of stem size and slippery sequence
13. Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein
14. Identification and characterization of a structural protein of hepatitis B virus: A polymerase and surface fusion protein encoded by a spliced RNA
15. Hepatitis B virus core proteins with an N-terminal extension can assemble into core-like particles but cannot be enveloped
16. Translational regulation of hepatitis B virus polymerase gene by termination-reinitiation of an upstream minicistron in a length-dependent manner
17. Expression and replication of the hepatitis B virus genome under foreign promoter control
18. Purification and structural characterization of the putative gag-pol protease of human immunodeficiency virus
19. Evidence for involvement of a ribosomal leaky scanning mechanism in the translation of the hepatitis B virus pol gene from the viral pregenome RNA
20. Interaction between hepatitis B virus core protein and reverse transcriptase
21. Proteolytic self-cleavage of hepatitis B virus core protein may generate serum e antigen
22. Close evolutionary relatedness of the hepatitis B virus and murine leukemia virus polymerase gene sequences
23. Common evolutionary origin of hepatitis B virus and retroviruses
24. Growth of human hepatoma cell lines with differentiated functions in chemically defined medium
25. Translational inactivation of RNA function: Discrimination against a subset of genomic transcripts during HBV nucleocapsid assembly
26. Hepatitis B virus replication
27. Mutational analysis of the hepatitis B virus P gene product: Domain structure and RNase H activity
28. Hepadnaviruses and retroviruses share genome homology and feature of replication
29. Generation and characterization of a host cell-dependent gag gene mutant of human immunodeficiency virus type 1
30. DNA sequencing with chain-terminating inhibitor
31. Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation
32. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells
33. gag-pol expressed from simian virus 40 late-replacement vector are efficiently processed and assembled into virus-like particles
34. Priming of duck hepatitis B virus reverse transcription in vitro: Premature termination of primer DNA induced by the 5′-triphosphate of fialuridine
35. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate
36. Cleavage of human immunodeficiency virus type 1 proteinase from the N-terminally adjacent p6* protein is essential for efficient Gag polyprotein processing and viral infectivity
37. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
38. Mutagenesis of protease cleavage sites in the human immunodeficiency virus type 1 gag polyprotein
39. In vitro activity of hepatitis B virus polymerase: Requirement for distinct metal ions and the viral epsilon stem-loop
40. Novel mechanism for reverse transcription in hepatitis B viruses
41. Putative reverse transcriptase intermediates of human hepatitis B virus in primary liver carcinomas
42. Production of hepatitis delta virus and suppression of helper hepatitis B virus in a human hepatoma cell line
43. Correlation of serum delta RNA with clinical course of acute hepatitis delta virus superinfection in Taiwan: A longitudinal study
44. Properties of monoclonal antibodies directed against hepatitis B virus polymerase protein