Mimicry between the hepatitis B virus DNA polymerase and the antigenic targets of nuclear and smooth muscle antibodies in chronic hepatitis B virus infection

Journal of Immunology

Volumn 162, Issue 3, 1999, Pages 1802-1810

  Gregorio, Germana V ^a,b   Choudhuri, Kaushik ^a   Ma, Yun ^a   Vegnente, Angela ^c   Mieli Vergani, Giorgina ^b   Vergani, Diego ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; DNA POLYMERASE; POL PROTEIN; SMOOTH MUSCLE ANTIBODY; VIRUS DNA;

ADOLESCENT; AMINO ACID SEQUENCE; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE HEPATITIS; CHILD; CHRONIC HEPATITIS; CONTROLLED STUDY; CROSS REACTION; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AMINO ACID SEQUENCE; ANTIBODIES, ANTINUCLEAR; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; AUTOANTIBODIES; AUTOANTIGENS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DNA-DIRECTED DNA POLYMERASE; FEMALE; GENE PRODUCTS, POL; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; MUSCLE, SMOOTH; NUCLEAR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033083860     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Gregorio, G. V., H. Jones, K. Choudhuri, A. Vegnente, F. Bortolotti, G. Mieli-Vergani, and D. Vergani. 1996. Autoantibody prevalence in chronic hepatilis B virus infection: effect of interferon-[alfa]. Hepatology. 24:520.
2. Gregorio, G. V., P. Jara, L. Hierro, C. Diaz, A. de la Vega, A. Vegnente, R. Iorio, F. Bortolotti, C. Crivellaro, L. Zancan, H. Daniels, B. Portmann, and G. Mieli-Vergani. 1996. Lymphoblastoid interferon-[alfa] with or without steroid pretreatment in children with chronic hepatitis B: a multicenter controlled trial. Hepatology 23:700.
3. Desmet, V. J., M. Gerber, J. H. Hoofnagle, M. Manns, and P. J. Scheuer. 1994. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 19:1513.
4. Johnson, P. J., and I. G. McFarlane. 1993. Meeting report: international autoimmune hepatitis group. Hepatology 18:998.
5. El-Shabrawi, M., M. L. Wilkinson, B. Portmann, G. Mieli-Vergani, S. K. F. Chong, R. Williams, and A. P. Mowat. 1987. Primary sclerosing cholangitis in childhood. Gastroenterology 92:1226.
6. Tan, E. M., A. S. Cohen, J. F. Frias, A. T. Masi, D. J. McShane, N. F. Rothlield, J. G. Schaller, N. Talal, and R. J. Winchester. 1982. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 17:1271.
7. Targoff, I. N. 1993. Polymyositis and dermatomyositis in adults. In Oxford Textbook of Rheumatology. P. J. Maddison, D. A. Isenberg, P. Woo, and D. N. Glass, eds. Oxford University Press, Oxford, pp. 809-810.
8. Wolf, H., S. Madrow, M. Matz, B. A. Jameson, G. Hermann, and B. Fortsch. 1988. An integrated family of amino acid sequence analysis programs. CABIOS 4:187.
9. Sternberg, M. J. E. 1991. PROMOT: A FORTRAN program to scan protein sequences against a library of known motifs. CABIOS 7:257.
10. Kemeny, D. M. 1990. A Practiral Guide to ELISA. Pergamon Press, Oxford, p. 115.
11. Redwood, C. S., and S. B. Marston. 1993. Binding and regulatory properties of expressed functional domains of chicken gizzard smooth muscle caldesmon. J. Biol. Chem. 268:10969.
12. Marston, S. B., and C. S. Redwood. 1991. The molecular anatomy of caldesmon. Biochem. J. 279:1.
13. Steimle, V., L. A. Otten, M. Zufferey, and B. Mach. 1993. Complementation cloning of an MHC class II transactivalor mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Cell 75:135.
14. Goldberg, M. W., and T. D. Allen. 1992. High resolution scanning electron microscopy of the nuclear envelope: demonstration of a new, regular, fibrous lattice attached to the baskets of the nucleoplasmic face of the nuclear pores. J. Cell Biol. 119:1429.
15. Compton, D. A., I. Szilak, D. W. Cleveland. 1992. Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis. J. Cell Biol. 116:1395.
16. Ge, Q., M. B. Frank, C. O'Brien, and I. N. Targoff. 1992. Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-scl autoantigen. J. Clin. Invest. 90:559.
17. Matsuoka, R., M. C. Yoshida, Y. Furutani, S. Imamura, N. Kanda, M. Yanagisawa, T. Masaki, and A. Takao. 1993. Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16ql2. Am. J. Med. Genet. 46:61.
18. Hayashi, K., H. Yano, T. Hashida, R. Takeuchi, O. Takeda, K. Asada, E. Takahashi, I. Kato, and K. Sobue. 1992. Genomic structure of the human caldesmon gene. Proc. Natl. Acad. Sci. USA 89:12122.
19. Kobayashi, M., and K. Koike. 1984. Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organisation. Gene 30:227.
20. Feitelson, M. A., I. Millman, G. Duncan, and B. S. Blumberg. 1988. Presence of antibodies to the polymerase gene product(s) of hepatitis B and woodchuck hepatitis virus in natural and experimental infections. J. Med. Virol. 24:121.
21. Von Herrath, M. G., and M. B. A. Oldstone. 1996. Virus-induced autoimmune disease. Curr. Opin. Immunol. 8:878.
22. Fujinami, R. S., and M. B. A. Oldstone. 1985. Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230:1043.
23. Tung, K. S. K. 1994. Mechanism of self-tolerance and events leading to autoimmune disease and autoantibody response. Clin. Immunol. Immunopathol. 73:275.
24. Wucherpfennig, K. W., and J. L. Strominger. 1995. Molecular mimicry in T-cell mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80:695.