Human T-cell leukemia virus type 1 tax protein binds to assembled nuclear proteasomes and enhances their proteolytic activity

Journal of Virology

Volumn 75, Issue 22, 2001, Pages 11106-11115

  Hemelaar, J ^a   Bex, F ^a   Booth, B ^a   Cerundolo, V ^a   McMichael, A ^a   Daenke, S ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE; PROTEASOME; REGULATOR PROTEIN; TAX PROTEIN; VIRUS ANTIGEN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HALF LIFE TIME; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; INFLAMMATION; LONG TERMINAL REPEAT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; VIRUS INFECTION;

BIOLOGICAL TRANSPORT; CELL LINE; CELL NUCLEUS; CYSTEINE ENDOPEPTIDASES; GENE PRODUCTS, TAX; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 0034761610     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.22.11106-11115.2001     Document Type: Article

References (58)

1. Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B Mol
2. Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm
3. I kappa B: A specific inhibitor of the NF-kappa B transcription factor
4. Proteasome components with reciprocal expression to that of the MHCencoded LMP proteins
5. Interaction of HTLV-I Tax with the human proteasome: Implications for NF-kappa B induction
6. Regulation of gene expression by HTLV-I Tax protein
7. The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins
8. Phosphorylation of the human T-cell leukemia virus type 1 transactivator Tax on adjacent serine residues is critical for Tax activation
9. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway
10. The Tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing 1KKalpha and 1KKbeta
11. K-Kgamma mediates the interaction of cellular kappaB kinases with the Tax transforming protein of human T cell leukemia virus type 1
12. High activated and memory cytotoxic T-cell responses to HTLV-1 in healthy carriers and patients with tropical spastic paraparesis
13. Contribution of proteasomal beta-subunits to the cleavage of peptide substrates analyzed with yeast mutants
14. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome
15. Movement of a karyophilic protein through the nuclear pores of oocytes
16. Interaction of HTLV-1 Tax1 with p67SRF causes the aberrant induction of cellular immediate early genes through CArG boxes
17. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes
18. Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases
19. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis
20. The interferon-gamma-inducible 11S regulator (PA28) and the LMP2/LMP7 subunits govern the peptide production by the 20S proteasome in vitro
21. Structure of 20S proteasome from yeast at 2.4 A resolution
22. IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein
23. Human proteasomes analysed with monoclonal antibodies
24. Structure of an IkappaBalpha/NF-kappaB complex
25. HLA alleles determine human T-lymphotropic virus(HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy
26. Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma
27. Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity
28. Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown
29. Different mechanisms control signal-induced degradation and basal turnover of the NFkappaB inhibitor IkappaB alpha in vivo
30. Control of cAMPregulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP
31. Naturally occurring variants of human T-cell leukemia virus type Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax
32. Nucleocytoplasmic transport: The last 200 nanometers
33. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B
34. Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously
35. Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax
36. Proteasomes: Protein degradation machines of the cell
37. Association between HTLV-1 Tax and kappa B alpha is dependent on the I kappa B alpha phosphorylation state
38. Dynamics of proteasome distribution in living cells
39. Intracellular distribution of proteasomes
40. Degradation of cell proteins and the generation of MHC class I-presented peptides
41. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
42. Nuclear retention of IkappaBalpha protects it from signal-induced degradation and inhibits nuclear factor kappaB transcriptional activation
43. A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription
44. Effects on NF-kappa B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome
45. Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
46. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I
47. Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I
48. Characterization of a novel nuclear localization signal in the HTLV-I tax transactivator protein
49. Identification of HTLV-I Tax transactivator mutants exhibiting novel transcriptional phenotypes
50. A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus
51. Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation
52. Adult T-cell leukemia: Clinical and hematologic features of 16 cases
53. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation
54. Re/NF-kappa B/I kappa B family: Intimate tales of association and dissociation
55. HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization
56. Structural basis for the activation of 20S proteasomes by 11S regulators
57. HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation
58. Multiple viral strategies of htlv-1 for dysregulation of cell growth control