TAN-1057A: A translational inhibitor with a specific inhibitory effect on 50S ribosomal subunit formation

Current Microbiology

Volumn 43, Issue 5, 2001, Pages 340-345

  Champney, W Scott ^a   Pelt, Jennifer ^a   Tober, Craig L ^a  

^a East Tennessee State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; NATURAL PRODUCT; PROTEIN; TAN 1057A; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; GROWTH INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RIBOSOME SUBUNIT; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; COLONY COUNT, MICROBIAL; DIPEPTIDES; INHIBITORY CONCENTRATION 50; PROTEIN BIOSYNTHESIS; RIBOSOMAL PROTEINS; STAPHYLOCOCCUS AUREUS;

STAPHYLOCOCCUS AUREUS;

EID: 0034761173     PISSN: 03438651     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002840010313     Document Type: Article

References (33)

1. Gram-positive resistance: Challenge for the development of new antibiotics
2. B resistance phenotype
3. Ketolides: New semisynthetic 14-membered macrolides
4. Macrolide antibiotic inhibition of 50S ribosomal subunit formation in bacterial cells
5. Azithromycin and clarithromycin inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells
6. Linezolid is a specific inhibitor of 50S ribosomal subunit formation in Staphylococcus aureus cells
7. Inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by eleven different ketolide antibiotics
8. A molecular investigation of the post-antibiotic effect of clarithromycin and erythromycin on Staphylococcus aureus cells
9. Evernimicin (SCH27899) inhibits both translation and 50S ribosomal subunit formation in Staphylococcus aureus cells
10. Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide and streptogramin B antibiotics
11. Structure-activity relationships for six ketolide antibiotics
12. A comparison of the inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by nine different macrolide antibiotics
13. The search for antimicrobial agents effective against bacteria resistant to multiple antibiotics
14. New directions in antibacterial research
15. Inhibition of protein synthesis by streptogramins and related antibiotics
16. Duration and clinical relevance of postantibiotic effect in relation to the dosing interval
17. In vitro activity of SCH27899 alone and in combination with 17 other antimicrobial agents
18. Simplified agar plate method for quantifying viable bacteria
19. Antimicrobial activity of SCH 27899, oligosaccharide member of the everninomycin class with a wide gram-positive spectrum
20. TAN-1057A-D, new antibiotics with potent antibacterial activity against methicillin resistant Staphylococcus aureus
21. Quinupristin/dalfopristin. A review of its use in the management of serious Gram-positive infections
22. The post-antibiotic effect
23. Genetic and biochemical characterization of mutations in Staphylococcus aureus that result in reduced susceptibility to Ziracin (SCH27899)
24. Evernimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both Gram-positive and Gram-negative bacteria
25. Pronounced postantibiotic effect of quinupristin-dalfopristin in static cultures of Staphylococcus aureus: An effect not seen with other antibiotics
26. Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and Enterococcus faecium
27. Mechanism of action of oxazolidinones: Effects of linezolid and eperezolid on translation rates
28. The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria
29. Comparative in-vitro activity of SCH 27899, a novel everninomicin, and vancomycin
30. Erythromycin inhibition of 50S ribosomal subunit formation in Escherichia coli cells
31. Total synthesis of the anti-MRSA peptide antibiotics TAN-1057 A-D
32. Synthesis and evaluation of TAN-1057 A/B analogs