A simple model for gene targeting

Biophysical Journal

Volumn 81, Issue 5, 2001, Pages 2876-2885

  Ratilainen, Tommi ^a   Lincoln, Per ^a   Nordén, Bengt ^a  

^a CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSTIC AGENT; PEPTIDE NUCLEIC ACID;

ARTICLE; BASE MISPAIRING; BINDING AFFINITY; DNA SEQUENCE; DOSE RESPONSE; ENTHALPY; EQUILIBRIUM CONSTANT; GENE TARGETING; STATISTICAL MODEL; TEMPERATURE;

EID: 0034759470     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(01)75928-0     Document Type: Article

References (29)

1. Invasion of the CAG triplet repeats by a complementary peptide nucleic acid inhibits transcription of the androgen receptor and TATA-binding protein genes and correlates with refolding of an active nucleosome containing a unique AR gene sequence
2. An assessment of the antisense properties of RNase H-competent and steric-blocking oligomers
3. Screening for genetic mutations
4. Targeted correction of an episomal gene in mammalian cells by a short DNA fragment tethered to a triplex-forming oligonucleotide
5. The new genetic medicines
6. Antisense medicinal chemistry
7. Oligonucleotide therapeutics
8. Physical constraints in the condensation of eukaryotic chromosomes: Local concentration of DNA versus linear packing ratio in higher order chromatin structures
9. PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules
10. In vitro transcription and translation inhibition by anti-promyelocytic leukemia (PML)/retinoic acid receptor a and anti-PML peptide nucleic acid
11. A formula for thermal stability (T-m) prediction of PNA/DNA duplexes
12. Cycle polyamide motif for recognition of the minor groove of DNA
13. Enthalpy and heat capacity changes for formation of an oligomeric DNA duplex: Interpretation in terms of coupled processes of formation and association of single-stranded helices
14. Kinetics for hybridization of peptide nucleic acids (PNA) with DNA and RNA studied with the BIAcore technique
15. Sequence selective DNA recognition by synthetic ligands
16. Peptide nucleic acids as therapeutic agents
17. An introduction to peptide nucleic acids
18. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
19. Nearest-neighbor thermodynamics and NMR of DNA sequences with internal A · A, C · C, G · G, and T · T mismatches.
20. Thermodynamics of sequence-specific binding of PNA to DNA
21. Sequence and structural selectivity of nucleic acid binding ligands
22. Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
23. Ionic effects on the stability and conformation of peptide nucleic acid (PNA) complexes
24. Antisense oligonucleotides: A new therapeutic principle
25. Detection of point mutation in the p53 gene using a peptide nucleic acid biosensor
26. Hybridisation based DNA screening on peptide nucleic acid (PNA) oligomer arrays
27. Direct observation of strand invasion by peptide nucleic acid (PNA) into double-stranded DNA
28. Extended DNA-recognition repertoire of peptide nucleic acid (PNA): PNA-dsDNA triplex formed with cytosine-rich homopyrimidine PNA
29. The relative stabilities of base pair stacking interactions and single mismatches in long RNA measured by temperature gradient gel electrophoresis