cDNA microarray analysis of multidrug resistance: Doxorubicin selection produces multiple defects in apoptosis signaling pathways

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 2, 2001, Pages 434-441

  Watts, George S ^a   Futscher, Bernard W ^b   Isett, Robert ^a   Gleason Guzman, Mary ^a   Kunkel, Mark W ^b   Salmon, Sydney E ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; COMPLEMENTARY DNA; DOXORUBICIN; FAS ANTIGEN; GENE PRODUCT; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DNA MICROARRAY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LEUKEMIA; MITOCHONDRION; MULTIDRUG RESISTANCE; MULTIPLE MYELOMA; NORTHERN BLOTTING; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TECHNIQUE; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CARCINOGENS; DNA; DNA, NEOPLASM; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; SIGNAL TRANSDUCTION; STAUROSPORINE; TUMOR CELLS, CULTURED;

EID: 0034758948     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. FAN, a novel WD-repeat protein. Couples the p55 tnf-receptor to neutral sphingomyelinase
2. BAD enables ceramide to signal apoptosis via Ras and Raf-1
3. SDZ PSC833, the cyclosporine analog and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug resistant cancer cells
4. Alteration of the daunorubicin-triggered sphingomyelin-ceramide pathway and apoptosis in MDR cells: Influence of drug transport abnormalities
5. Mechanisms of drug resistance in hematologic malignancies
6. Cell adhesion mediated drug resistance (CAM-DR): Role of integrins and resistance to apoptosis in human myeloma cell lines
7. Drug-target interactions: Only the first step in the commitment to a programmed cell death?
8. Anomalous expression of P-glycoprotein in highly drug-resistant human KB cells
9. Quantitative polymerase chain reaction analysis of mdr1 mRNA in multiple myeloma cell lines and clinical specimens
10. Functions of ceramide in coordinating cellular responses to stress
11. Apoptosis and the dilemma of cancer chemotherapy
12. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
13. Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis
14. Phospholipase A2 is necessary for tumor necrosis factor α-induced ceramide generation in L929 cells
15. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha
16. P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death
17. Regulation of ceramide production and apoptosis
18. Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice
19. Selection for drug resistance results in resistance to Fas-mediated apoptosis
20. Myeloma cells selected for resistance to CD-95-mediated apoptosis are not cross-resistant to cytotoxic drugs: Evidence for independent mechanisms of caspase activation
21. Cross-resistance of CD95- and drug-induced apoptosis as a consequence of deficient activation of caspases (ICE/Ced-3 proteases)
22. Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells
23. Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
24. Signal transduction of stress via ceramide
25. Effect of concentration on the cytotoxic mechanism of doxorubicin-apoptosis and oxidative DNA damage
26. Cellular resistance to anthracyclines
27. P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway
28. Two CD95 (APO-1/Fas) signaling pathways
29. 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol chemosensitizes neuroblastoma cells for taxol and vincristine
30. Adriamycin activation and oxygen free radical formation in human breast tumor cells: Protective role of glutathione peroxidase in adriamycin resistance
31. The drug efflux protein. P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis
32. The central executioner of apoptosis: Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95 and ceramide induced apoptosis
33. BCL-X expression in multiple myeloma: Possible indicator of chemoresistance
34. MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
35. Resistance to TNF-alpha and adriamycin in the human breast cancer MCF-7 cell line: Relationship to MDR1, MnSOD, and TNF gene expression