Behavioral abnormalities of Zic1 and Zic2 mutant mice: Implications as models for human neurological disorders

Behavior Genetics

Volumn 31, Issue 3, 2001, Pages 317-324

  Ogura, Hiroo ^a,c   Aruga, Jun ^b   Mikoshiba, Katsuhiko ^b,c  

^a EISAI CO LTD   (Japan)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Cerebellar function; Gene targeting.; Hypotonia; Joubert syndrome; Sensorimotor gating abnormality; Startle response

Indexed keywords

GENE PRODUCT; PROTEIN ZIC1; PROTEIN ZIC2; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; AUDITORY STIMULATION; BRAIN MALFORMATION; CEREBELLUM DISEASE; CEREBELLUM VERMIS; CONTROLLED STUDY; DISEASE MODEL; GENE MUTATION; HOLOPROSENCEPHALY; HOMOZYGOSITY; JOUBERT SYNDROME; LOCOMOTION; MALE; MOUSE; NEURAL TUBE; NEUROLOGIC DISEASE; NONHUMAN; PREPULSE INHIBITION; PROTEIN EXPRESSION; SCHIZOPHRENIA; SENSORIMOTOR FUNCTION; SPINA BIFIDA; STARTLE REFLEX;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; DISEASE MODELS, ANIMAL; HOLOPROSENCEPHALY; HUMANS; MICE; MICE, KNOCKOUT; MICE, NEUROLOGIC MUTANTS; MODELS, GENETIC; MUSCLE HYPOTONIA; SCHIZOPHRENIA; SYNDROME; TRANSCRIPTION FACTORS;

EID: 0034752383     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012235510600     Document Type: Article

References (35)

1. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
2. A novel zinc finger protein, Zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells
3. The mouse Zic gene family: Homologues of Drosophila pair-rule gene odd-paired
4. Mouse Zic1 is involved in cerebellar development
5. Zic1 regulates the patterning of vertebral arches in cooperation with Gli3
6. Odd-paired: A zinc finger pair-rule protein required for the timely activation of engrailed and wingless in Drosophila embryos
7. Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired
8. Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex
9. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice
10. Influence of separate and combined septal and amygdala lesions on memory, acoustic startle, anxiety, and locomotor activity in rats
11. A note on a simple apparatus for detecting neurological deficit in rats and mice
12. Competitive receptor antagonists disrupt prepulse inhibition without reduction of startle amplitude in a dopamine receptor-independent manner in mice
13. Impaired motor learning performance in cerebellar En-2 mutant mice
14. The mechanism of cerebellar hypotonia. An experimental study in the monkey
15. The cerebellum of man
16. Comprehensive observational assessment. Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse
17. Prepulse inhibition of acoustic startle, a measure of sensorimotor gating: Effects of antipsychotics and other agents in rats
18. Familial agenesis of the cerebellar vermis. A syndrome of episodic hyperpnea, abnormal eye movements, ataxia, and retardation
19. The neurobiology of startle
20. The acoustic startle response in rats - Circuits mediating evocation, inhibition and potentiation
21. Social interaction and sensorimotor gating abnormalities in mice lacking Dv11
22. The use of a plus-maze to measure anxiety in the mouse
23. Effects of septal lesions on fear-potentiated startle, and on the anxiolytic effects of buspirone and diazepam
24. The expression of the mouse Zic1, Zic2 and Zic3 gene suggests an essential role for Zic gene in body pattern formation
25. Zic2 regulates the kinetics of neurulation
26. Xenopus Zic3, a primary regulator both in neural and neural crest development
27. Xenopus Zic family and its role in neural and neural crest development
28. Inbred strain difference in prepulse inhibition of the mouse startle response
29. Impaired cerebellar synaptic plasticity and motor performance in mice lacking the mGluR4 subtype of metabotropic glutamate receptor
30. Behavioral despair in rats: A new model sensitive to antidepressant treatments
31. Joubert syndrome: A review
32. Role of the cerebellum in tuning anticipatory and reactive grip force responses
33. Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia
34. 13q deletion syndrome in an adult mentally retarded patient
35. NCAM-180 knockout mice display increased lateral ventricle size and reduced prepulse inhibition of startle