Effects of the amino acid glutamine on frequency of chromosomal aberrations induced by gamma radiation in Wistar rats

Mutation Research - Genetic Toxicology

Volumn 370, Issue 2, 1996, Pages 121-126

  Tavares, Denise Crispim ^a   Takahashi, Catarina S ^a,b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Depto Biologia   (Brazil)

Author keywords

Bone marrow cell; Chromosomal aberration; Glutamate; Ionizing radiation

Indexed keywords

GLUTAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; FEMALE; GAMMA RADIATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIATION PROTECTION; RAT;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0030582436     PISSN: 01651218     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-1218(96)00067-5     Document Type: Article

References (37)

1. [1] Windmueller, H.G. and A.E. Spaeth (1974) Uptake and metabolism of plasm glutamine by the small intestine, J. Biol. Chem., 249, 5070-5079.
2. [2] Kovacevic, Z. and H.P. Morris (1972) The role of glutamine in the oxidative metabolism of malignant cells, Cancer Res., 32, 326-333.
3. [3] Zielke, H.R., P.T. Ozand, J.T. Tildon, D.A. Sevdalian and M. Cornblath (1978) Reciprocal regulation of glucose and glutamine utilization by cultured human diploid fibroblast, J. Cell. Physiol., 95, 41-48.
4. [4] Souba, W.W., R.J. Smith and D.W. Wilmore (1985) Glutamine metabolism by the intestinal tract: Invited review, J. Parenter. Enteral Nutr., 9, 608-617.
5. [5] Newsholme, E.A., B. Crabtree and M.S.M. Ardawi (1985) Glutamine in lymphocytes: its biochemical, physiological and clinical importance, Q. J. Exp. Physiol., 70, 473-489.
6. [6] Welbourne, T.C. (1987) Interorgan glutamine flow in metabolic acidosis, Am. J. Physiol., 253, F1069-F1076.
7. [7] McLennan, P.A., R.A. Brown and M.J. Rennie (1987) A positive relationship between protein synthetic rate and intracellular glutamine in perfused rat skeletal muscle, FEBS Lett., 215, 187-191.
8. [8] Souba, W.W., V.S. Klimberg, D.A. Plumley, R.M. Salloum, T.C. Flynn, K.I. Bland and E.M. Copeland (1990) The role of glutamine in maintaing gut structure and function and supporting the metabolic response to injury and infection, J. Surg. Res., 48, 383-391.
9. [9] Klimberg, V.S., R.M. Salloum, M. Kasper, D.A. Plumley, D.J. Dolson, R.D. Hautamaki and W.M. Mendenhall (1990) Oral glutamine accelerates healing of the small intestine and improves outcome after whole abdominal radiation, Arch. Surg., 125, 1040-1045.
10. [10] Klimberg, V.S., W.W. Souba, D.J. Dolson, R.M. Salloum, R.D. Hautamaki, D.A. Plumley and W.M. Mendenhall (1990) Prophylatic glutamine protects the intestinal mucosa from radiation injury, Cancer, 66, 62-68.
11. [11] Klimberg, V.S., W.W. Souba and R.M. Salloum (1990) Glutamine-enriched diets support muscle glutamine without stimulating tumor growth, J. Surg. Res., 48, 319-323.
12. [12] Souba, W.W., V.S. Klimberg and E.M. Copeland (1990) Glutamine nutrition in the management of radiation enteritis, J. Parenter. Enteral Nutr., 14 (Suppl.), 106S-108S.
13. [13] Ford, C.E. and J.L. Hamerton (1956) A colchicine hypotonic citrate squash sequence for mammalian chromosomes, Stain Technol., 3, 247-251.
14. [14] Savage, J.R.K. (1976) Classification and relationships of induced chromosomal structural changes, J. Med. Genet., 13, 103-122.
15. a Edn., 718p.
16. [16] Schloerb, P.R. and M. Amare (1993) Total parenteral nutrition with glutamine in bone marrow transplantation and other clinical applications (A randomized, double-blind study), J. Parenter. Enteral Nutr., 17, 407-413.
17. [17] Ziegler, T.R., K. Benfell, R.J. Smith, L.S. Young, E. Brown, E. Ferrari-Baliviera, D.K. Lowe and D.W. Wilmore (1990) Safety and metabolic effects of L-glutamine administration in humans, J. Parenter. Enteral Nutr., 14 (Suppl.), 1375-1465.
18. [18] Ziegler, T.R., L.S. Young, K. Benfell, M. Scheltinga, K. Hortos, R. Bye, F.D. Morrow, D.O. Jacobs, R.J. Smith, J.H. Antin and D.W. Wilmore (1992) Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation (A randomized, double-blind, controlled study), Ann. Intern. Med., 116, 821-828.
19. [19] Alexander, J.W. (1993) Immunoenhancement via enteral nutrition, Arch. Surg., 128, 1242-1245.
20. [20] Souba, W.W. (1993) Glutamine and cancer, Ann. Surg., 218, 715-728.
21. [21] O'Riordain, M.G., K.C.H. Fearon, J.A. Roos, P. Rogers, J.S. Falconer, D.C.C. Bartolo, O.J. Garden and D.C. Carter (1994) Glutamine-supplemented total parenteral nutrition enhances T-lymphocyte response in surgical patients undergoing colorectal resection, Ann. Surg., 220, 212-221.
22. [22] Déchelotte, P., D. Darmaun, M. Rongier, B. Hecketsweiler, O. Rigal and J.F. Desjeux (1991) Absorption and metabolic effects of enterally administered glutamine in humans, Am. J. Physiol., 260, G677-682.
23. [23] Harper, A.E., N.J. Benevenga and R.M. Wohlhueter (1970) Effects of ingestion of disproportinale amounts of amino acids, Physiol. Rev., 50, 428-555.
24. [24] Dudrick, P.S. and W.W. Souba (1991) Amino acids in surgical nutrition: principles and pratice, Surg. Clin. North Am., 71, 459-476.
25. [25] Mobrahan, S. (1992) Glutamine: a conditionally essential nutrient or another nutritional puzzle, Nutr. Rev., 50, 331-333.
26. [26] Vanderhoof, J.A., D.J. Blackwood, H. Mohammadpour and J.H.Y. Park (1992) Effects of oral supplementation of glutamine on small intestinal mucosal mass following resection, J. Am. Coll. Nutr., 11, 223-227.
27. [27] Souba, W.W. (1993) Total parenteral nutrition with glutamine in bone marrow transplantation and other clinical applications, J. Parenter. Enteral Nutr., 17, 403.
28. [28] Koltun, W.A., M.M. Bloomer and T.C. Vary (1994) Glutamine does not increase ammonia in systemically drained small bowel transplants, J. Surg. Res., 56, 102-107.
29. [29] Bulus, N., E. Cersosimo, F. Ghishan and N.N. Abumrad (1989) Physiologic importance of glutamine, Metabolism, 38 (Suppl.), 1-5.
30. [30] Souba, W.W. (1991) Glutamine: a key substrate for the splanchnic bed, Annu. Rev. Nutr., 11, 285-308.
31. [31] Herskowitz, K., T.G. Baumgartner, T.R. Austgen, M.K. Chen and W.W. Souba (1990) Stability and sterility of glutamine in solution, J. Parenter. Enteral Nutr., 14 (Suppl.), 19S.
32. [32] Ardawi, M.S.M. and E.A. Newsholme (1985) Glutamine metabolism in lymphocytes and its importance in the immune response, Essays Biochem., 21, 1-44.
33. [33] Newsholme, E.A., P. Newsholme, R. Curi, E. Challouner and M.S.M. Ardawi (1988) A role for muscle in the immune system and its importance in surgery, trauma, sepsis and burns, Nutrition, 4, 261-268.
34. [34] Hong, R.W., J.D. Rounds, W. S. Helton, M.K. Robinson and D.W. Wilmore (1992) Glutamine preserves liver glutathione after lethal hepatic injury, Ann. Surg., 215, 114-119.
35. [35] Bedford, J.S. (1991) Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations, Int. J. Radiation Oncology Biol. Phys., 21, 1457-1469.
36. [36] Jagetia, G.C. (1993) Radiation-induced chromosomal aberrations in the bone marrow of mice exposed to various doses of gamma radiation, Radiat. Environ. Biophys., 32, 109-117.
37. [37] Preston, R.J., B.J. Dean, S. Galloway, H. Holden, A.F. McFee and M. Shelby (1987) Mammalian in vivo cytogenetic assays. Analysis of chromosome aberrations in bone marrow cells, Mutation Res., 189, 157-165.