Amino acids of Epstein-Barr virus nuclear antigen 3A essential for repression of Jκ-mediated transcription and their evolutionary conservation

Journal of Virology

Volumn 75, Issue 1, 2001, Pages 90-99

  Dalbies Tran, R ^a   Stigger Rosser, E ^a   Dotson, T ^a   Sample, C E ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS ANTIGEN; TRANSCRIPTION FACTOR; VIRUS ANTIGEN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; B LYMPHOCYTE; CELL IMMORTALIZATION; CONSENSUS SEQUENCE; DNA BINDING; DOWN REGULATION; EPSTEIN BARR VIRUS; EVOLUTION; HERPES VIRUS; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; CONSERVED SEQUENCE; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; EVOLUTION; HUMANS; MOLECULAR SEQUENCE DATA; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 0034749275     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.1.90-99.2001     Document Type: Article

References (64)

1. Notch signalling: Cell fate control and signal integration in development
2. Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity
3. Transcriptional repression by the Epstein Barr virus EBNA-3A protein tethered to DNA does not require RBP-Jκ
4. Inhibition of the DNA-binding activity of Drosophila Suppressor of Hairless and of its human homolog, KBF2/RBP-Jκ, by direct protein-protein interaction with Drosophila Hairless
5. Evolution of two types of rhesus lymphocryptovirus similar to type 1 and type 2 Epstein-Barr virus
6. Multiple functions within the Epstein-Barr virus EBNA-3A protein
7. U2 region of the Epstein-Barr virus DNA may encode Epstein-Barr virus nuclear antigen 2
8. The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor
9. Properties of a baboon lymphotropic herpesvirus related to Epstein-Barr virus
10. 5' Coding and regulatory sequence divergence with conserved function of the Epstein-Barr virus LMP2A homolog in herpesvirus papio
11. Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1
12. Identification of a novel protein encoded by the BamHI A region of the Epstein-Barr virus
13. Transcriptional activation signals found in the Epstein-Barr virus (EBV) latency C promoter are conserved in the latency C promoter sequences from baboon and rhesus monkey EBV-like lymphocryptoviruses (cercopithicine herpesviruses 12 and 15)
14. Biologic and antigenic characteristics of Epstein-Barr virus-related herpesviruses of chimpanzees and baboons
15. The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the Jκ recombination signal binding protein
16. Colinearity between the DNAs of Epstein-Barr virus and herpesvirus papio
17. Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa
18. Isolation and characterization of the genes for two small RNAs of herpesvirus papio and their comparison with Epstein-Barr virus-encoded EBER RNAs
19. Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2
20. Truncated mammalian Notch 1 activates CBF1/RBPJκ-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2
21. CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex
22. Signaling downstream of activated mammalian Notch
23. delta-1 activation of Notch-1 signalling results in HES-1 transactivation
24. Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by Jκ and PU.1
25. EBNA 2 and EBNA 3C extensively and mutually exclusively associate with RBPJκ in Epstein-Barr virus-transformed B lymphocytes
26. The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression
27. A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
28. Epstein-Barr virus and its replication
29. Regulation of interleukin-1β transcription by Epstein-Barr virus involves a number of latent proteins via their interaction with RBP
30. Epstein-Barr nuclear antigen-3 and -4 interact with RBP-2N, a major isoform of RBP-Jκ in B lymphocytes
31. Identification and characterization of an Epstein-Barr virus nuclear antigen 2-responsive cis element in the bidirectional promoter region of latent membrane protein and terminal protein 2 genes
32. The Epstein-Barr virus determined nuclear antigens EBNA 3A, 3B, and 3C repress EBNA 2-mediated transactivation of the viral terminal protein 1 gone promoter
33. The neurogenic Suppressors of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of split complex genes triggered by notch signaling
34. Contribution of conserved amino acids in mediating the interaction between EBNA2 and CBF1/RBPJκ
35. The Epstein-Barr virus immortalizing protein EBNA 2 is targeted to DNA by a cellular enhancer-binding protein
36. EBNA-2 of herpesvirus papio diverges significantly from the type A and type B EBNA-2 proteins of Epstein-Barr virus but retains an efficient transactivation domain with a conserved hydrophobic motif
37. Epstein-Barr virus nuclear antigen 3C is a transcriptional regulator
38. The molecular evolutionary history of the herpesviruses
39. An animal model for acute and persistent Epstein-Barr virus infection
40. The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription
41. NF-κB2 is a putative target gene of activated Notch-1 via RBP-Jκ
42. Sequence and functional analysis of EBNA-LP and EBNA2 proteins from nonhuman primate lymphocryptoviruses
43. Recombination signal sequence binding protein Jκ is constitutively bound to the NF-κB site of the interleukin-6 promoter and acts as a negative regulatory factor
44. Epstein-Barr virus nuclear antigen 3C interacts with histone deacetylase to repress transcription
45. Adeno-associated virus Rep protein synthesis during productive infection
46. Epstein-Barr virus
47. Epstein-Barr virus nuclear protein 3C modulates transcription through interaction with the sequence-specific DNA-binding protein J kappa
48. The amino-terminal Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJκ
49. The lyric origin of herpesvirus papio is highly homologous to Epstein-Barr virus ori-Lyt: Evolutionary conservation of transcriptional activation and replication signals
50. GAL4 fusion vectors for expression in yeast or mammalian cells
51. Epstein-Barr virus: Molecular biology
52. Epstein-Barr virus types 1 and 2 differ in their EBNA 3A, EBNA 3B, and EBNA 3C genes
53. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
54. LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein
55. Epstein-Barr virus nuclear proteins EBNA-3A and EBNA-3C are essential for B-lymphocyte growth transformation
56. Delineation of the cis-acting element mediating EBNA-2 transactivation of latent infection membrane protein association
57. Comparison of the EBNA1 proteins of Epstein-Barr virus and herpesvirus papio in sequence and function
58. Both A type and B type Epstein-Barr virus nuclear antigen 6 interact with RBP-2N
59. RBP-Jκ repression activity is mediated by a co-repressor and antagonized by the Epstein-Barr virus transcription factor EBNA 2
60. The human Jκ recombination signal sequence binding protein (RBP-Jκ) targets the Epstein-Barr virus EBNA 2 protein to its DNA responsive elements
61. Epstein-Barr virus EBNA 3A and EBNA 3C proteins both repress RBP-Jκ-EBNA2-activated transcription by inhibiting the binding of RBP-Jκ to DNA
62. Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP-1
63. A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jκ
64. Epstein-Barr virus nuclear antigen 3C activates the intent membrane protein 1 promoter in the presence of Epstein-Barr virus nuclear antigen 2 through sequences encompassing an Spi-1/Spi-B binding site