EBNA-2 and EBNA-3C extensively and mutually exclusively associate with RBPJκ in Epstein-Barr virus transformed B lymphocytes

Journal of Virology

Volumn 70, Issue 6, 1996, Pages 4179-4183

  Johannsen, Eric ^a   Miller, Cheryl L ^a   Grossman, Steven R ^a,c   Kieff, Elliott ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; EPSTEIN BARR VIRUS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; TRANSCRIPTION REGULATION; VIRUS CELL INTERACTION;

ANTIGENS, VIRAL; B-LYMPHOCYTES; DNA-BINDING PROTEINS; EPSTEIN-BARR VIRUS NUCLEAR ANTIGENS; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; LYMPHOCYTE ACTIVATION; NUCLEAR PROTEINS; PRECIPITIN TESTS;

EID: 0029948549     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Abbot, S. D., M. Rowe, K. Cadwallader, A. Ricksten, J. Gordon, F.Wang, L. Rymo, and A. B. Rickinson. 1990. Epstein-Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein. J. Virol. 64:2126-2134.
2. 1-arrested cells. J. Virol. 68:3491-3498.
3. Amakawa, R., W. Jing, K. Ozawa, N. Matsunami, V. Hamaguchi, F. Matsuda, M. Kawaichi, and T. Honjo. 1993. Human Jk recombination signal binding protein protein gene (IGKJRB): comparison with its mouse homologue. Genomics 17:306-315.
4. Artavanis-Tsakonas, S., K. Matsuno, and M. E. Fortini. 1995. Notch signaling. Science 268:222-232.
5. Brou, C., F. Logeat, M. Lecourtois, J. Vandekerckhove, P. Kourilsky, F. Schweisguth, and A. Israel. 1994. Inhibition of the DNA-binding activity of Drosophila suppressor of Hairless and of its human homolog, KBF2/RBPJk, by direct protein-protein interaction with Drosophila Hairless. Genes Dev. 8:2491-2203.
6. Cohen, J., and E. Kieff. 1991. An Epstein-Barr virus nuclear protein 2 domain essential for transformation is a direct transcriptional activator. J. Virol. 62:2880-2882.
7. Cohen, J., F. Wang, and E. Kieff. 1991. Epstein-Barr virus nuclear protein 2 mutations define essential domains for transformation and transactivation. J. Virol. 65:2545-2554.
8. Cohen, J. I., F. Wang, J. Mannick, and E. Kieff. 1989. Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation. Proc. Natl. Acad. Sci. USA 86:9228-9262.
9. Couso, J. P., and A. Martinez Arias. 1994. Notch is required for Wingless signaling in the epidermis of Drosophila. Cell 79:229-272.
10. Dou, S., X. Zeng, P. Cortes, H. Erdjument-Bromage, P. Tempst, T. Honjo, and L. D. Vales. 1994. The recombination signal sequence-binding protein RBP-2N functions as a transcriptional repressor. Mol. Cell. Biol. 14:3310-3319.
11. Ellisen, L. W., J. Bird, D. C. West, A. L. Soreng, T. C. Reynolds, S. D. Smith, and J. Sklar. 1991. Tan-1, the human homolog of the Drosophilia notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649-661.
12. Finke, J., M. Rowe, B. Kallin, I. Ernberg, A. Rosen, J. Dillner, and G. Klein. 1987. Monoclonal and polyclonal antibodies against Epstein-Barr virus nuclear antigen 5 (EBNA-5) detect multiple protein species in Burkitt s lymphoma and lymphoblastoid cell lines. J. Virol. 61:3870-3878.
13. Fortini, M. E., and S. Artavanis-Tsakonas. 1994. The Suppressor of Hairless protein participates in Notch receptor signaling. Cell 79:273-282.
14. Furukawa, T., S. Maruyama, M. Kawaichi, and T. Honjo. 1992. The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development. Cell 69:1191-1197.
15. Goodbourn, S. 1995. Notch takes a short cut. Nature (London) 377:288-289.
16. Grossman, S. R., E. Johannsen, X. Tong, R. Yalamanchili, and E. Kieff. 1994. The Epstein-Barr virus nuclear antigen 2 transactivator is directed to response elements by the Jk recombination signal binding protein. Proc. Natl. Acad. Sci. USA 91:7268-7272.
17. Hamaguchi, Y., Y. Yamamoto, H. Iwanari, S. Maruyama, T. Furukawa, N. Matsunami, and T. Honjo. 1992. Biochemical and immunological characterization of the DNA binding protein (RBP-Jk) to mouse Jk recombination signal sequence. J. Biochem. 112:314-320.
18. Hammerschmidt, W., and B. Sugden. 1989. Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes. Nature (London) 340:393-397.
19. Henkel, T., P. D. Ling, S. D. Hayward, and M. G. Peterson. 1994. Mediation of Epstein-Barr virus EBNA-2 transactivation by recombination signal-binding protein Jk. Science 265:92-95.
20. Hennessy, K., and E. Kieff. 1985. A second nuclear protein is encoded by Epstein-Barr virus in latent infection. Science 227:1238-1240.
21. Hsieh, J. J., and D. Hayward. 1995. Masking of the CBF1/RBPJkappa transcriptional repression domain by Epstein-Barr virus EBNA-2. Science 268:260-263.
22. Jarriault, S., C. Brou, F. Logeat, E. Schroeter, R. Kopan, and A. Israel. 1995. Signalling downstream of activated notch. Nature (London) 377:355-358.
23. Johannsen, E., E. Koh, G. Mosialos, X. Tong, E. Kieff, and S. R. Grossman. 1995. Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by Jk and PU.1. J. Virol. 69:253-262.
24. Kempkes, B., D. Pich, R. Zeidler, B. Sudgen, and W. Hammerschmidt. 1995. Immortalization of human B lymphocytes by a plasmid containing 71 kilobase pairs of Epstein-Barr virus DNA. J. Virol. 69:231-238.
25. Laux, G., L. Adam, J. Strobl, and F. Moreau-Gachelin. 1994. The Spi-1/PU.l and Spi-B ets family transcription factors and the recombination signal binding protein RBP-Jk interact with an Epstein-Barr Virus nuclear protein 2 responsive cis-element. EMBO J. 13:5624-5632.
26. Lecourtois, M., and F. Schweisguth. 1995. The neurogenic Suppressor of Hairless DNA-binding protein mediates the transcriptional activation of the Enhancer of Split Complex genes triggered by Notch signaling. Genes Dev. 9:2598-2608.
27. Le Roux, A., B. Kerdilles, D. Walls, J. Dedieu, and M. Perricaudet. 1994. The Epstein-Barr virus determined nuclear antigens EBNA-3A, EBNA-3B, EBNA-3C repress EBNA-2 mediated transactivation of the viral terminal protein 1 gene promoter. Virology 205:595-602.
28. Ling, P. D., D. R. Rawlins, and S. D. Hayward. 1993. The Epstein-Barr virus immortalizing protein EBNA-2 is targeted to DNA by a cellular enhancerbinding protein. Proc. Natl. Acad. Sci. USA 90:9237-9241.
29. Marshall, D., and C. Sample. 1995. Epstein-Barr virus nuclear antigen EBNA-3C is a transcriptional regulator. J. Virol. 69:3624-3630.
30. Matsunami, N., Y. Hamaguchi, Y. Yamamoto, K. Kuze, K. Kangawa, and H. Matsuo. 1989. A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif. Nature (London) 342:934-937.
31. Maunders, M., L. Petti, and M. Rowe. 1994. Precipitation of the EpsteinBarr virus nuclear protein EBNA 2 by an EBNA 3C specific monoclonal antibody. J. Gen. Virol. 75:769-778.
32. Petti, L., C. Sample, and E. Kieff. 1990. Subnuclear localization and phosphorylation of Epstein-Barr virus latent infection nuclear proteins. Virology 176:563-574.
33. Robertson, E., J. Lin, and E. Kieff. 1996. The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJK. J. Virol. 70:3068-3074.
34. Robertson, E. S., S. Grossman, E. Johannsen, C. Miller, J. Lin, B. Tomkinson, and E. Kieff. 1995. Epstein-Barr virus nuclear protein EBNA-3C modulates transcription through interaction with the sequence-specific DNAhinding protein Jk. J. Virol. 69:3108-3116.
35. Schweisguth, F., and J. W. Posakony. 1992. Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates. Cell 69:1199-1212.
36. Silins, S. L., and T. B. Sculley. 1994. Modulation of Vimentin, the CD40 activation antigen and Burkitt's lymphoma antigen (CD77) by the EpsteinBarr virus nuclear antigen EBNA 4. Virology 202:16-24.
37. Tomkinson, B., and E. Kieff. 1992. Use of second-site homologous recombination to demonstrate that Epstein-Barr virus nuclear protein EBNA-3B is not important for lymphocyte infection or growth transformation in vitro. J. Virol. 66:2393-2903.
38. Tomkinson, B., E. S. Robertson, and E. Kieff. 1993. Epstein-Barr virus nuclear proteins EBNA-3A and EBNA-3C are essential for B-lymphocyte growth transformation. J. Virol. 67:2014-2025.
39. Tong, X., R. Drapkin, D. Reinberg, and E. Kieff. 1995. The p62 and p80 subunits mediate TFIIH interaction with the Epstein-Barr virus protein 2. Proc. Natl. Acad. Sci. USA 92:3259-3263.
40. Tong, X., R. Drapkin, R. Yalamanchili, G. Mosialos, and E. Kieff. 1995. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. Mol. Cell. Biol. 15:4732-4744.
41. Tong, X., F. Wang, C. J. Thut, and E. Kieff. 1995. The Epstein-Barr virus nuclear protein 2 acidic domain can interact with TFIIB, TAF40, and RPA70 but not with TATA-binding protein. J. Virol. 69:585-588.
42. Wang, F., C. Gregory, C. Sample, R. Murray, D. Liebowitz, M. Rowe, A. Rickinsnn, and E. Kieff. 1990. Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23. J. Virol. 64:2309-2318.
43. Wang, F., S.-F. Tsang, M. G. Kurilla, J. I. Cohen, and E. Kieff. 1990. Epstein-barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.J. Virol. 64:3407-3416.
44. Yalamanchili, R., S. Harada, and E. Kieff. 1996. The N-terminal half of EBNA2, except for seven prolines, is not essential for primary B-lymphocyte growth transformation. J. Virol. 70:2468-2473.
45. Yalamanchili, R., X. Tong, S. R. Grossman, E. Johannsen, G. Mosialos, and E. Kieff. 1994. Genetic and biochemical evidence that EBNA 2 interaction with a 63 kDa cellular GTG-binding protein is essential for B lymphocyte growth transformation by EBV. Virology 204:634-641.
46. Young, L., C. Alfleri, K. Hennessy, H. Evans, C. O'Hara, K. C. Anderson, J. Ritz, R. S. Shapiro, A. Rickinson, E. Kieff, and J. I. Cohen. 1989. Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. N. Engl. J. Med. 321:1080-1085.
47. Zimber-Strobl, U., L. Strobl, C. Meitinger, R. Hinrichs, T. Sakai, T. Furukawa, T. Honjo, and G. Bornkamm. 1994. Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-Jk, the homologue of Drosophilia Suppressor of Hairless. EMBO J. 13:4973-4982.