Intracerebroventricular adrenomedullin stimulates the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system and production of hypothalamic nitric oxide

Journal of Neuroendocrinology

Volumn 13, Issue 11, 2001, Pages 975-984

  Shan, J ^a   Krukoff, T L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

ACTH; C fos; Locus coeruleus; Paraventricular nucleus; Tyrosine hydroxylase

Indexed keywords

ADRENOMEDULLIN; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; MESSENGER RNA; NITRATE; NITRIC OXIDE; NITRITE; PROTEIN FOS; TYROSINE 3 MONOOXYGENASE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; AREA POSTREMA; ARTERIAL PRESSURE; ARTICLE; AUTONOMIC NERVOUS SYSTEM; BRAIN NERVE CELL; BRAIN STEM; CONSCIOUSNESS; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; HEART RATE; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHESIS; INJECTION; LOCUS CERULEUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; SOLITARY TRACT NUCLEUS; THALAMUS MIDLINE NUCLEUS;

ADRENOCORTICOTROPIC HORMONE; ADRENOMEDULLIN; ANIMALS; ARCUATE NUCLEUS; ARGININE VASOPRESSIN; BLOOD PRESSURE; CORTICOTROPIN-RELEASING HORMONE; GENE EXPRESSION; HEART RATE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INJECTIONS, INTRAVENTRICULAR; LOCUS COERULEUS; MALE; NADPH DEHYDROGENASE; NEURONS; NITRIC OXIDE; OXYTOCIN; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PEPTIDES; PITUITARY-ADRENAL SYSTEM; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SOLITARY NUCLEUS; SYMPATHETIC NERVOUS SYSTEM; TYROSINE 3-MONOOXYGENASE; VASODILATOR AGENTS;

EID: 0034748694     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2001.00721.x     Document Type: Article

References (42)

1. Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma
2. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin
3. Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma
4. Distribution of novel CGRP1 receptor and adrenomedullin receptor mRNAs in the rat central nervous system
5. An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat
6. Distribution of adrenomedullin-like immunoreactivity in the rat central nervous system by light and electron microscopy
7. The distribution of preproadrenomedullin mRNA in the rat central nervous system and its modulation by physiological stressors
8. Hypothalamic integration: Organization of the paraventricular and supraoptic nuclei
9. The central adrenergic system. An immunofluorescence study of the location of cell bodies and their efferent connections in the rat utilizing dopamine-beta-hydroxylase as a marker
10. An immunohistochemical study of the organization of catecholaminergic cells and terminal fields in the paraventricular and supraoptic nuclei of the hypothalamus
11. Rat medulla oblongata. II. Dopaminergic, noradrenergic (A1 and A2) and adrenergic neurones, nerve fibers, and presumptive terminal processes
12. Central action of nitric oxide in regulation of autonomic functions
13. Stress-induced activation of nitric oxide-producing neurones in the rat brain
14. Immune stress activates putative nitric oxide-producing neurones in rat brain: Cumulative effects with restraint
15. Hypotension induces Fos immunoreactivity in NADPH-diaphorase positive neurones in the paraventricular and supraoptic hypothalamic nuclei of the rat
16. L-NAME modulates responses to adrenomedullin in the hindquarters vascular bed of the rat
17. Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat
18. Nitric oxide regulates body temperature, neuroneal activation and interleukin-1β gene expression in the hypothalamic paraventricular nucleus in response to immune stress
19. Changes in blood volume and pressure induce c-fos expression in brainstem neurones that project to the paraventricular nucleus of the hypothalamus
20. Central actions of adrenomedullin on cardiovascular parameters and sympathetic outflow in conscious rats
21. Centrally induced vasopressor and sympathetic responses to a novel endogenous peptide, adrenomedullin, in anesthetized rats
22. Area postrema ablation attenuates activation of neurones in the paraventricular nucleus in response to systemic adrenomedullin
23. Hemodynamic, hormonal, and renal effects of intracerebroventricular adrenomedullin in conscious sheep
24. ACTH-suppressive and vasodilator actions of adrenomedullin in conscious sheep
25. A novel vasoactive peptide, adrenomedullin, inhibits pituitary adrenocorticotropin release
26. Hypertensive rats exhibit heightened expression of corticotropin-releasing factor in activated central neurones in response to restraint stress
27. Central mechanisms for the hypertensive effects of preproadrenomedullin-derived peptides in conscious rats
28. Afferent regulation of locus coeruleus neurones: Anatomy, physiology and pharmacology
29. Spatially and temporally differentiated patterns of c-fos expression in brainstem catecholaminergic cell groups induced by cardiovascular challenges in the rat
30. Expression of Fos-like protein in brain following sustained hypertension and hypotension in conscious rabbits
31. Directionally specific changes in arterial pressure induce differential patterns of Fos expression in discrete areas of the rat brainstem: A double-labeling study for Fos and catecholamines
32. c-Fos expression in brain in responses to hypotension and hypertension in conscious rat
33. In vitro recordings from area postrema neurones demonstrate responsiveness to adrenomedullin
34. Adrenomedullin microinjection into the area postrema increases blood pressure
35. Interconnections between the neuroendocrine hypothalamus and the central autonomic system
36. Centrally administered adrenomedullin increases plasma oxytocin level with induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of the rat
37. A physiological role for adrenomedullin in rats; a potent hypotensive peptide in the hypothalamo-neurohypophysial system
38. Oxytocin and vasopressin. From genes to peptides
39. Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats
40. Nitric oxide in neuroimmune feedback signaling
41. Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro
42. Interaction between corticotropin-releasing factor and nitric oxide in mediating the response of the rat hypothalamus to immune and non-immune stimuli