Neutrophil proteases can inactive human PAR3 and abolish the co-receptor function of PAR3 on murine platelets

Thrombosis and Haemostasis

Volumn 85, Issue 3, 2001, Pages 533-538

  Cumashi, A ^a   Ansuini, H ^a   Celli, N ^a   De Blasi, A ^a   O'Brien, P J ^a   Brass, L F ^a   Molino, M ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Cathepsin G; Protease activated receptors; Proteases; Thrombin

Indexed keywords

CATHEPSIN G; ELASTASE; PHOSPHOLIPASE C; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 3; THROMBIN; CATHEPSIN; PANCREATIC ELASTASE; PROTEASE-ACTIVATED RECEPTOR 3; PROTEASE-ACTIVATED RECEPTOR 4; PROTEINASE ACTIVATED RECEPTOR 4; SERINE PROTEINASE; THROMBIN RECEPTOR;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; ENZYME ACTIVITY; ERYTHROCYTE; ERYTHROCYTE AGGREGATION; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL STRAIN COS1; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETIC TRANSFECTION; HUMAN; METABOLISM; MOLECULAR GENETICS; THROMBOCYTE; THROMBOCYTE AGGREGATION;

AMINO ACID SEQUENCE; ANIMALS; BLOOD PLATELETS; CATHEPSINS; COS CELLS; HUMANS; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PANCREATIC ELASTASE; PHOSPHOLIPASE C; PLATELET AGGREGATION; RECEPTORS, THROMBIN; SERINE ENDOPEPTIDASES; THROMBIN; TRANSFECTION;

EID: 0034745133     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615617     Document Type: Article

References (28)

1. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
2. Molecular cloning of a potential proteinase activated receptor
3. Protease-activated receptor 3 is a second thrombin receptor in humans
4. A dual thrombin receptor system for platelet activation
5. Cloning and characterization of human protease-activated receptor 4
6. Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2
7. Interaction of mast cell tryptase with thrombin receptors and PAR-2
8. Thrombin responses in human endothelial cells: Contribution from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1
9. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin
10. Characterization of protease-activated receptor-2 immunoreactivity in normal tissues
11. Evidence for the presence of a proteinase-activated receptor distinct from the thrombin receptor in vascular endothelial cells
12. The human proteinase-activated receptor-3 (PAR-3) gene. Identification within a PAR gene cluster and characterization in vascular endothelial cells and platelets
13. Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin
14. PAR3 is a cofactor for PAR4 activation by thrombin
15. Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G
16. Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G and proteinase 3: Evidence for distinct cleavage sites within the aminoterminal domain of the thrombin receptor
17. Cathepsin G activates protease-activated receptor-4 in human platelets
18. Platelet activation by fMLP-stimulated polymorphonuclear leukocytes: The activity of cathepsin G is not prevented by antiproteinases
19. Post-translational and activation-dependent modifications of the G protein-coupled thrombin receptor
20. 14C-serotonin by human platelets pretreated with chymotrypsin or serratia marcescens protease
21. Plasmin-platelet interaction involves cleavage of functional thrombin receptor
22. Pretreatment of human platelets with plasmin inhibits responses to thrombin, but potentiates responses to low concentrations of aggregating agents, including the thrombin receptor activating peptide, SFLLRN
23. Plasmin desensitization of the PAR1 thrombin receptor: Kinetics, sites of truncation, and implications for thrombolytic therapy
24. 2+ responses of protease-treated human platelets activated with α-thrombin and the tethered ligand peptide
25. Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation
26. High expression of β-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation
27. Internalization and recycling of activated thrombin receptors
28. More pieces of the platelet activation puzzle slide into place